In vitro antifungal susceptibility of clinical isolates of Candida spp. obtained from patients with different predisposing factors to candidosis

Abstract

The increase in the number of infections caused by Candida species and the consequent use of antifungal agents favours an increase of resistant isolates. The aim of this study was to evaluate the antifungal susceptibility of Candida spp. isolates from patients with different systemic predisposing factors to candidosis. Seventy-nine Candida spp. isolates were assayed for in vitro susceptibility to amphotericin B, fluconazole, 5-flucytosine and itraconazole using the technique proposed by the Clinical and Laboratory Standards Institute (CLSI). Four C. albicans, one C. guilliermondii, four C. parapsilosis and two C. tropicalis isolates were resistant to amphotericin B. Only two isolate was resistant to itraconazole. All the isolates tested were susceptible to fluconazole and flucytosine. It could be concluded that the most efficient drugs against the Candida isolates studied were fluconazole and flucytosine and that all of the antifungal agents used in this study were effective against the Candida spp. isolates tested.

Quantitative Investigation of Efficiency of Ultraviolet and Visible Light in Eradication ofCandida albicans In Vitro

“…3 The widespread use of topical and systemic antifungal agents as conventional treatment for oral candidosis has resulted in the development of resistance in C. albicans. 4,5 Because the conventional antifungal agents exert a more fungistatic than fungicidal effect, prophylaxis is often inadequate. 6 Therefore, it becomes necessary to develop alternative therapies for the treatment of oral candidosis.…”

Susceptibilities of Candida albicans Mouth Isolates to Antifungal Agents, Essentials Oils and Mouth Rinses

“…The yeast Candida albicans is a commensal organism frequently found in the oral cavity [1] that can cause opportunistic infections when some predisposing factors are present among the immunodeficiency, endocrine disorders, age extremes, radiotherapy, antibiotic therapies, transplants, malignant diseases and the use of orthodontic appliances [2][3][4][5]. The most common treatment is the use of antifungal agents, such as azoles (fluconazole, itraconazole, miconazole and ketoconazole) and polyenes (amphotericin B or nystatin).…”

Synthesis and biological evaluation of novel 2,4-disubstituted-1,3-thiazoles as anti-Candida spp. agents

“…As a matter of fact, a significant number of fungi species (especially Candida glabrata and Candida krusei) exhibited primary resistance to amphotericin B or was less susceptible to triazoles [4]. Furthermore, as a consequence of the toxicity of the currently used polyene antifungal drugs, which leads to interrupt the therapy, and the emergence of candidal species resistant to azole-based agents, there is an urgent need for developing alternative drug therapies [5].…”