In vitro and in vivo activity of Peganum harmala L. alkaloids against phytopathogenic bacteria

Shaheen, Hanan A.; Issa, Marwa Y.

doi:10.1016/j.scienta.2019.108940

Cited by 50 publications

(47 citation statements)

References 60 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…[ [84][85][86][87][88][89][90] Anti-proliferative effects a. Some triterpenoids isolated from P. harmala exhibited potent anti-proliferative activities.…”

Section: Discussionmentioning

confidence: 99%

Improving health benefits with considering traditional and modern health benefits of Peganum harmala

2021

View full text Add to dashboard Cite

Background Medicinal plants are potential source of natural products that play an important role in preventing different human diseases. P. harmala is used traditionally as emmenagogue and an abortifacient agent in the Middle East, North of Africa and West of China. It belongs to the family of Zygophyllaceae and it is a wild growing flowering plant. Its seeds are main medicinal part of the plant. Methods The current searching was done by the keywords in main indexing systems including PubMed/MEDLINE, Scopus, and Institute for Scientific Information Web of Science as well as the search engine of Google Scholar. The keywords were wild rue, traditional medicine, Harman, health benefits, and pharmaceutical science. Results The most important uses of P. harmala in traditional pharmaceutical sciences are in cardiovascular, gasterointestinal, nervous, endocrine, neoplasm and tumors, pain relieving, organisms, diabetes, respiratory, disinfectant, anti-pyretic, skin and hair, rheumatism, arthritis and inflammation, and ulcers. Pharmacological effects of P. harmala are in cardiovascular system, nervous system, antimicrobial effects, antineoplasm, nervous system, endocrine, gastrointestinal effects, osteocytes, endocrine and respiratory system. Phenolic compounds are the main reason of antioxidant capacity. Conclusions Due to its pharmacological activities, P. harmala is a high potential medicinal herb and the suggestion is to increases by doing research in efficacy and safety.

show abstract

“…[ [84][85][86][87][88][89][90] Anti-proliferative effects a. Some triterpenoids isolated from P. harmala exhibited potent anti-proliferative activities.…”

Section: Discussionmentioning

confidence: 99%

Improving health benefits with considering traditional and modern health benefits of Peganum harmala

2021

View full text Add to dashboard Cite

show abstract

“…Efforts to find alternative antioxidants and antibacterial agents from natural sources have been intensified in recent times because of their effectiveness, safety, and efficacy. Natural antioxidants have proved to be as effective antimicrobials as synthetic antibiotics [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

“…It is a perennial herbaceous, glabrous plant that grows in semiarid conditions, steppe areas, and sandy soils P. harmala is native to the eastern Mediterranean area and is extensively spread in Middle and East Asia and North Africa. P. harmala total alkaloids extract has been reported to be an effective antibacterial on phytopathogenic bacteria [11]. Several known and undescribed triterpenoids have been isolated from P. harmala L. with potent anti-proliferative activities through the induction of apoptosis in HeLa cells [16].…”

Section: Introductionmentioning

confidence: 99%

Antioxidant, Antibacterial, and Phytochemical Screening of Ethanolic Crude Extracts of Libyan Peganum harmala Seeds

Allaq

Sidik

Abdul-Aziz

et al. 2021

JPRI

View full text Add to dashboard Cite

Peganum harmala is one of the most famous medicinal plants and natural products commonly used in traditional medicine and extensively spread in Middle and East Asia and North Africa. This study aimed to evaluate the radical scavenging activity of ethanolic crude extracts of P. harmala seeds from Libya using DPPH assay; to determine the minimum inhibitory concentration (MIC) and minimum bactericidal concentrations (MBC) of the P. harmala seeds crude extracts against Gram-negative Salmonella typhi ATCC14028 and Escherichia coli ATCC 25922 and also Gram-positive Bacillus subtilis ATCC 6633 and Staphylococcus aureus ATCC 33591; and to screen the phytochemicals in the ethanolic crude extracts of the Libyan P. harmala seeds using gas chromatography-mass spectrometry (GC-MS). The IC50 value of P. harmala seeds extract was 179.62±7.32 μg/mL. The MIC ranged from 1.95 to 31.25 mg/mL while the MBC ranged from 7.80 to 62.50 mg/mL. The eight compounds identified were harmine, harmaline, leptalorine, hexahydro fluorene, 3-methoxy-6-methyl, 1H-pyrido [3,4-b]indole,2,34,9- tetrahydro-6methoxy-1-methyl, 9,12-octadienoic acid ethyl ester, linoleic acid ethyl ester, 9,12-octadienoic acid (z,z). This study has, therefore, revealed the antixodant and antibacterial efficacy of P. harmala ethanolic extract. Thus, it could be further developed as a substitute for chemical antioxidants and as antibacterials agent.

show abstract

“…It can be found in many organisms, including plants and butterflies. Tobacco, Peganum harmala (widely in Middle Eastern) and lemon balm are listed as natural sources of harmine [ 1 , 2 , 3 ]. Harmine is an inhibitor of monoamine oxidase (MAOIs) and antagonist of 5-hydroxytryptamine (5-HT) [ 4 , 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

“…Harmine (7-methoxy-1-methyl-9H-pyrido [3,4,6]indole), known as banisterine, is a fluorescent harmala alkaloid. It is a member of the beta-carboline family.…”

Section: Introductionmentioning

confidence: 99%

Solid-Contact Potentiometric Sensors Based on Main-Tailored Bio-Mimics for Trace Detection of Harmine Hallucinogen in Urine Specimens

et al. 2021

View full text Add to dashboard Cite

All-solid-state potentiometric sensors have attracted great attention over other types of potentiometric sensors due to their outstanding properties such as enhanced portability, simplicity of handling, affordability and flexibility. Herein, a novel solid-contact ion-selective electrode (SC-ISE) based on poly(3,4-ethylenedioxythiophene) (PEDOT) as the ion-to-electron transducer was designed and characterized for rapid detection of harmine. The harmine-sensing membrane was based on the use of synthesized imprinted bio-mimics as a selective material for this recognition. The imprinted receptors were synthesized using acrylamide (AA) and ethylene glycol dimethacrylate (EGDMA) as functional monomer and cross-linker, respectively. The polymerization process was carried out at 70 °C in the presence of dibenzoyl peroxide (DBO) as an initiator. The sensing membrane in addition to the solid-contact layer was applied to a glassy-carbon disc as an electronic conductor. All performance characteristics of the presented electrode in terms of linearity, detection limit, pH range, response time and selectivity were evaluated. The sensor revealed a wide linearity over the range 2.0 × 10−7–1.0 × 10−2 M, with a detection limit of 0.02 µg/mL and a sensitivity slope of 59.2 ± 0.8 mV/hamine concentration decade. A 40 mM Britton–Robinson (BR) buffer solution at pH of 6 was used for all harmine measurements. The electrode showed good selectivity towards harmine over other common interfering ions, and maintained a stable electrochemical response over two weeks. After applying the validation requirements, the proposed method revealed good performance characteristics. Method precision, accuracy, bias, trueness, repeatability, reproducibility, and uncertainty were also evaluated. These analytical capabilities support the fast and direct assessment of harmine in different urine specimens. The analytical results were compared with the standard liquid chromatographic method. The results obtained demonstrated that PEDOT/PSS was a promising solid-contact ion-to-electron transducer material in the development of harmine-ISE. The electrodes manifested enhanced stability and low cost, which provides a wide number of potential applications for pharmaceutical and forensic analysis.

show abstract

In vitro and in vivo activity of Peganum harmala L. alkaloids against phytopathogenic bacteria

Cited by 50 publications

References 60 publications

Improving health benefits with considering traditional and modern health benefits of Peganum harmala

Improving health benefits with considering traditional and modern health benefits of Peganum harmala

Antioxidant, Antibacterial, and Phytochemical Screening of Ethanolic Crude Extracts of Libyan Peganum harmala Seeds

Solid-Contact Potentiometric Sensors Based on Main-Tailored Bio-Mimics for Trace Detection of Harmine Hallucinogen in Urine Specimens

Contact Info

Product

Resources

About