In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhiza glabra (licorice)

Yu, Xue; Xue, Charlie Changli; Zhou, Zhi Wei; Li, Chun Guang; Du, Yao; Liang, Jun; Zhou, Shu Feng

doi:10.1016/j.lfs.2007.10.019

Cited by 127 publications

(85 citation statements)

References 54 publications

(53 reference statements)

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“…7 The root of Glycyrrhiza glabra (licorice) has been used for many centuries in Asia and Europe as an antioxidant, antidote, demulcent, expectorant, and a remedy for allergic inflammation, as well as a flavoring and sweetening agent. 8 Glabridin, an active isoflavan in the hydrophobic fraction of licorice root, 9,10 is easily incorporated into the gut cells and released to the basolateral side by aglycone form in human 1 and mice. 11,12 It has shown multiple biological activities, such as antibacterial, neuroprotective, antiatherosclerotic, antiosteoporosis, and immunomodulatory activities.…”

Section: Introductionmentioning

confidence: 99%

Glabridin Inhibits Migration, Invasion, and Angiogenesis of Human Non–Small Cell Lung Cancer A549 Cells by Inhibiting the FAK/Rho Signaling Pathway

et al. 2011

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This study reports the antimigration, anti-invasive effect of glabridin, a flavonoid obtained from licorice, in human non-small cell lung cancer A549 cells. Glabridin exhibited effective inhibition of cell metastasis by decreasing cancer cell migration and invasion of A549 cells. In addition, glabridin also decreased A549-mediated angiogenesis. Further investigation revealed that glabridin's inhibition of cancer angiogenesis was also evident in a nude mice model. Blockade of A549 cells migration was associated with an increase of anb3 integrin proteosome degradation. Glabridin also decreased the active forms of FAK and Src, and enhanced levels of inactivated phosphorylated Src (Tyr 527), decreasing the interaction of FAK and Src. Inhibition of the FAK/Src complex by glabridin also blocked Akt activation, resulting in reduced activation of RhoA and myosin light chain phosphorylation. This study demonstrates that glabridin may be a novel anticancer agent for the treatment of lung cancer in 3 different ways: inhibition of migration, invasion, and angiogenesis.

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Section: Introductionmentioning

confidence: 99%

Glabridin Inhibits Migration, Invasion, and Angiogenesis of Human Non–Small Cell Lung Cancer A549 Cells by Inhibiting the FAK/Rho Signaling Pathway

et al. 2011

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“…13,26 Various studies conducted on these ingredients have proved that most of these test drugs possess important neuroprotective, antioxidant and anti-inflammatory actions. The flavonoid glabridin derived from Glycyrrhiza glabra (Aslus'soos) significantly decreases the volume of focal infarct, apoptosis 31 and cerebral histological damage 32 as well as antioxidant activity is also reported in Glycyrrhiza glabra has the neuroprotective effect through alteration of multiple pathways link with apoptosis 33 Essential oil from seeds of Foeniculum vulgare (Badyan) showed antithrombotic activity, thus preventing the paralysis induced by collagen-epinephrine intravenous injection 34 Another study on Badyan (Foeniculum vulgare) has been found to dissolve the blood clot after hemorrhagic stroke 35 which may be attributed to its monoamine inhibitor activity that upregulates the level of serotonin, nor-epinephrine, and dopamine in brain and thus brain plasticity is accomplished 36 Operculia turpethum 37 Cassia fistula. 38 Experimental studies concluded that Lavandula stoechas i.e.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Mā-Ul-Ūsool, Mus'hil-E-Balgham and Inkibāb With Marzanjosh in Management of Post- Stroke Disability With Respect to Adl: A Black Box Study

Alam¹,

Khalid²,

Ansari³

2017

J Biol Sci Opin

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Falij-e-Nisfi (hemiplegia) is a disease characterized by loss of motor and sensory functions in longitudinal half of the body. The present study was conducted to evaluate the efficacy of Ma-ul-Usool (root extracts), Mus'hil-e-Balgham (phlegm purgative) and Inkibab (steam inhalation) with Marzanjosh in management of post-stroke disability with respect to Activities of Daily Living (ADL) on scientific parameters. It was an open label, pre and post without control clinical trial for the period of 30 days conducted on 29 eligible cases of hemiplegia due to stroke. Nuskha Ma-ul-Usool was administered in form of decoction once in morning on an empty stomach for 15 days; then Nuskha Mus'hil-e-Balgham was added with Ma-ulUsool and given on 13 th and 15 th day of treatment in order to induce purgation. From 16 th day onwards, Inkibab (steam inhalation) was started with 20 gm of Marzanjosh once a day daily till the end of the study. The pre and post treatment values of Barthel Index Scale were analyzed by paired t test to assess ADL in the participants. Significant improvement (P<0.05) was observed in ADL of participants at the end of treatment. No side effect was observed during and after the study; overall compliance to the treatment was satisfactory. The study concluded that trial formulations have statistically significant effect in improving the ADL of post stroke disability cases.

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“…This result indicates the selective toxicity of EB, especially the aerial extract, against cancer cells. The low IC 50 values indicate that the cytotoxic effects of the extracts are more potent than those of various extracts from other members of the Fabaceae family are (Kim et al, 2008;Yu et al, 2008). Wang and Jiao (2001) reported that the ability of compounds to efficiently induce apoptosis in cancer cells indicates anticancer activity.…”

Section: Discussionmentioning

confidence: 99%

Cytotoxic and immunomodulatory effects of Ebenus boissieri Barbey on breast cancer cells

et al. 2016

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ABSTRACT. We aimed to determine the cytotoxic and immunomodulatory effects of hydroalcoholic extracts of the roots and aerial parts of Ebenus boissieri (EB) on breast cancer MDA-MB231 cells and the non-cancerous human embryonic kidney cell line, 293T. Cell viability was determined by MTT assay, trypan blue exclusion, and Live/Dead Viability/Cytotoxicity assay. Apoptosis was evaluated by measuring the activity of caspase-2, 3, 6, 8, and 9. Tumor necrosis factor (TNF)-α and interferon (IFN)-g release was assayed by ELISA, and protein expression of caspase-3, TNF-α, and IFN-g was determined by western blot. The results of this study revealed that MDA-MB231 cell viability was reduced in a dose-dependent manner by the aerial and root extract of EB at 72 h with a half-maximal inhibitory concentration (IC 50 ) of 41.1 ± 2.76 and 65 ± 1.09 µg/mL, respectively. In contrast, neither the aerial nor the root extracts of this plant inhibited the proliferation of 293T cells at doses up to 1000 µg/mL. There was a time-dependent increase in caspase activity, especially caspase-3 and caspase-9. The levels of TNF-α and IFN-g significantly increased in MDA-MB231 cells treated with aerial extract. In conclusion, the extracts of EB induced apoptosis in breast cancer cells by altering the levels of caspases, TNF-α, and IFN-g. The components and precise modes of action of EB have not yet been determined. However, potential antitumor and immunomodulatory activity was observed along with selectivity against cancer cells in vitro, suggesting that hydroalcoholic extracts of this plant are worthy of additional study.

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In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhiza glabra (licorice)

Cited by 127 publications

References 54 publications

Glabridin Inhibits Migration, Invasion, and Angiogenesis of Human Non–Small Cell Lung Cancer A549 Cells by Inhibiting the FAK/Rho Signaling Pathway

Glabridin Inhibits Migration, Invasion, and Angiogenesis of Human Non–Small Cell Lung Cancer A549 Cells by Inhibiting the FAK/Rho Signaling Pathway

Efficacy of Mā-Ul-Ūsool, Mus'hil-E-Balgham and Inkibāb With Marzanjosh in Management of Post- Stroke Disability With Respect to Adl: A Black Box Study

Cytotoxic and immunomodulatory effects of Ebenus boissieri Barbey on breast cancer cells

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