In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from Enteromorpha prolifera

Kim, Jin‐Kyung; Cho, Myoung Lae; Karnjanapratum, Supatra; Shin, Il‐Shik; You, Sung Hyun

doi:10.1016/j.ijbiomac.2011.08.032

Cited by 194 publications

(78 citation statements)

References 26 publications

(31 reference statements)

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“…SPs are associated with the surface of animal cells and are involved in biological activities, such as cell recognition, cell adhesion, and regulation of receptor functions, which are of great interest in medicine [16,17,18,19]. For example, well-known SPs of green seaweeds from Ulva and Enteromorpha , which are called ulvans, and their oligosaccharides, have demonstrated strong antitumor and immune-modulating activities [20,21,22,23,24], antihyperlipidemic activities [25,26], and anticoagulant activities [27,28,29,30]. …”

Section: Introductionmentioning

confidence: 99%

Overview on Biological Activities and Molecular Characteristics of Sulfated Polysaccharides from Marine Green Algae in Recent Years

et al. 2014

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Among the three main divisions of marine macroalgae (Chlorophyta, Phaeophyta and Rhodophyta), marine green algae are valuable sources of structurally diverse bioactive compounds and remain largely unexploited in nutraceutical and pharmaceutical areas. Recently, a great deal of interest has been developed to isolate novel sulfated polysaccharides (SPs) from marine green algae because of their numerous health beneficial effects. Green seaweeds are known to synthesize large quantities of SPs and are well established sources of these particularly interesting molecules such as ulvans from Ulva and Enteromorpha, sulfated rhamnans from Monostroma, sulfated arabinogalactans from Codium, sulfated galacotans from Caulerpa, and some special sulfated mannans from different species. These SPs exhibit many beneficial biological activities such as anticoagulant, antiviral, antioxidative, antitumor, immunomodulating, antihyperlipidemic and antihepatotoxic activities. Therefore, marine algae derived SPs have great potential for further development as healthy food and medical products. The present review focuses on SPs derived from marine green algae and presents an overview of the recent progress of determinations of their structural types and biological activities, especially their potential health benefits.

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Section: Introductionmentioning

confidence: 99%

Overview on Biological Activities and Molecular Characteristics of Sulfated Polysaccharides from Marine Green Algae in Recent Years

et al. 2014

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“…In recent years, numerous polysaccharides isolated from natural resources have been proven to possess a wide range of biological properties and few adverse effects. These non-cytotoxic compounds, polysaccharides attracted attention as immunomodulators exhibiting variety beneficial pharmacological effects, such as anti-tumor, anti-inflammatory and anticomplementary activities (Kim, Cho, Karnjanapratum, Shin, & You, 2011;Zhao et al, 2014;Liu et al, 2014;Peng, Zhang, Zeng, & Kennedy, 2005;Chang, Lur, Lu, & Cheng, 2013;Benenica, Rodriguez, Matulewicz, & Coulombié, 1999). Hence, the study of chemical properties and immunomodulatory effects of polysaccharides is necessary.…”

Section: Introductionmentioning

confidence: 99%

Purification, characterization and immunomodulatory activity of a polysaccharide from Celosia cristata

Sun

Peng

Zhao

et al. 2015

Carbohydrate Polymers

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“…The proliferation of RAW264.7 cells was determined using WST-1 colorimetric assay as described by Kim et al 25) The immunomodulatory activity of the SPs was determined on the basis of nitric oxide (NO) production in the macrophage culture supernatant and the nitrite concentration was measured using the Griess reaction 26) as previously described.…”

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confidence: 99%

Characterization and immunomodulatory activities of polysaccharides from Spirogyra neglecta (Hassall) Kützing

Surayot

Jian-guo

Lee

et al. 2015

Bioscience, Biotechnology, and Biochemistry

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Sulfated polysaccharides (SP) isolated from freshwater green algae, Spirogyra neglecta (Hassall) Kützing, and fractionated SPs were examined to investigate their molecular characteristics and immunomodulatory activity. The crude and fractionated SPs (F1, F2, and F3) consisted mostly of carbohydrates (68.5–85.3%), uronic acids (3.2–4.9%), and sulfates (2.2–12.2%) with various amounts of proteins (2.6–17.1%). d-galactose (23.5–27.3%), d-glucose (11.5–24.8%), l-fucose (19.0–26.7%), and l-rhamnose (16.4–18.3%) were the major monosaccharide units of these SPs with different levels of l-arabinose (3.0–9.4%), d-xylose (4.6–9.8%), and d-mannose (0.4–2.3%). The SPs contained two sub-fractions with molecular weights (Mw) ranging from 164 × 103 to 1460 × 103 g/mol. The crude and fractionated SPs strongly stimulated murine macrophages, producing considerable amounts of nitric oxide and various cytokines via up-regulation of their mRNA expression by activation of nuclear factor-kappa B and mitogen-activated protein kinases pathways. The main backbone of the most immunoenhancing SP was (1→3)-l-Fucopyranoside, (1→4,6)-d-Glucopyranoside, and (1→4)-d-Galactopyranoside.

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In vitro and in vivo immunomodulatory activity of sulfated polysaccharides from Enteromorpha prolifera

Cited by 194 publications

References 26 publications

Overview on Biological Activities and Molecular Characteristics of Sulfated Polysaccharides from Marine Green Algae in Recent Years

Overview on Biological Activities and Molecular Characteristics of Sulfated Polysaccharides from Marine Green Algae in Recent Years

Purification, characterization and immunomodulatory activity of a polysaccharide from Celosia cristata

Characterization and immunomodulatory activities of polysaccharides from Spirogyra neglecta (Hassall) Kützing

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