In vitro and in vivo studies on biodegradable magnesium alloy

Hou, Linrui; Li, Zhen; Pan, Yu; Du, Lianteng; Li, Xinlin; Zheng, Yufeng; Li, L i

doi:10.1016/j.pnsc.2014.09.002

Cited by 50 publications

(29 citation statements)

References 21 publications

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“…This method is cumbersome, and moreover, the H 2 gas collection instruments often suffer leakage. Monitoring the biodegradation process in vivo can be done by micro-CT, which requires a major equipment investment, and by X-ray absorption, which is also expensive, involves exposure to radiation [8][9][25][26][27][28][29][30], and requires further time consuming complex analysis involving understanding the difference in X-ray absorption coefficients of the different corrosion products formed for quantization. Therefore, a simple and effective in vivo H 2 sensing method is needed for animal testing of alloys and devices.…”

Section: Introductionmentioning

confidence: 99%

In vivo monitoring the biodegradation of magnesium alloys with an electrochemical H2 sensor

et al. 2016

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Biomedical devices such as plates and screws used for broken bone repair are being developed out of biodegradable magnesium alloys that gradually dissolve when no longer needed. This avoids subsequent removal by surgery, which may be necessary if complications arise. A rapid, non-invasive means for monitoring the biodegradation process in vivo is needed for animal testing and point of care (POC) evaluation of patients. Here we report a novel, simple, fast, and noninvasive method to monitor the biodegradation of magnesium in vivo by measuring the biodegradation product H2 with an electrochemical H2 sensor. Since H2 rapidly permeates through biological tissue, measurements are made by simply pressing the sensor tip against the skin above the implant; the response is within 30s.

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Section: Introductionmentioning

confidence: 99%

In vivo monitoring the biodegradation of magnesium alloys with an electrochemical H2 sensor

et al. 2016

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“…A pH increase above 7.8 may result in alkaline poisoning (Song, ) and inflammatory responses (Li et al, ; Razavi et al, ), which explains the background of the requirement. Moderate hydrogen release : The corrosion of magnesium‐based implants forms hydrogen (Witte et al, ). Despite the rapid diffusion and absorption (Aghion, Levy, & Ovadia, ; Dziuba et al, ; Gu, Xie, Li, Zheng, & Qin, ; Hänzi, Gerber, Schinhammer, Löffler, & Uggowitzer, ; Hou et al, ; Liu, Yang, Tan, Li, & Zhang, ; Pichler et al, ; Razavi et al, ; Song & Atrens, ; Witte et al, ; Witte et al, ) of this gas, a moderate and controlled release mechanism is required during the degradation process. Rapid production of large amounts of hydrogen can promote the loss of mechanical integrity due to hydrogen embrittlement (Choudhary & Singh Raman, ; Gu, Zhou, Zheng, Cheng, et al, ; Jafari et al, ; Kannan, ), the formation of temporary gas cavities (Witte et al, ) and/or the impairment of blood circulation (Song, ).…”

Section: Results Of Empirical Investigationmentioning

confidence: 99%

Development of magnesium implants by application of conjoint‐based quality function deployment

Siefen

Höck

2019

J Biomedical Materials Res

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Biodegradable magnesium‐based implants are the subject of a great deal of research for different orthopedic and vascular applications. The targeted design and properties depend on the specific medical function and location in the body. Development of the biomaterial requires a comprehensive understanding of the biological interaction between the implant and the host tissue, as well as of the behavior in the physiological environment in vivo. Research into and the development of innovative magnesium implants entails interdisciplinary research efforts and communication between materials science, bioscience, and medical experts. The present study provides a transparent planning and communication tool for market‐oriented implant development processes. The objective was to identify medical needs at an early stage of the development process and to quantify the importance of the engineering characteristics of different research fields that cater to specific implant requirements. The method is demonstrated by the performance of a survey‐based conjoint analysis, which was integrated into a quality function deployment approach. Twenty‐seven medical professionals and 29 biomaterial scientists assessed the importance of identified medical requirements, whereby the control of mechanical integrity and degradation along with nontoxicity and nonimmunogenicity showed the highest number of preferences. The evaluation of implant options by 31 experts indicated that the engineering characteristic with the highest importance was the condition and sterilization of the surface. These values can be used to set priorities in strategic decisions. Research trials can be aligned to medical preferences, ensuring high product quality and an effective development process. This is the first paper to report on the application of conjoint‐based quality function deployment in biomaterial research.

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“…Magnesium-based biomaterials have amazing advantages over stainless steel, titanium or Co-Cr-Ni alloys, which leave metallic residues resulting from in vivo abrasion with toxic effects that can cause hypersensitivity, local inflammation or tissue necrosis [1,4,6]. Magnesium alloy has chemically active properties and is susceptible to degradation in the physiological environment after implantation without causing toxic and secondary effects [3,7,8]. The researchers made a comparison of the most used elements in the medical implant industry, namely magnesium, iron and zinc (these are considered biodegradable base materials for use in the medical industry), and found that,from the point of view of the main properties, magnesium meets all the criteria to be considered a good biodegradable material (Table 1) …”

Section: The Interaction Clinical Responsementioning

confidence: 99%

Topical Notions About in Vivo Analysis for Degradable Biomaterials with Utility in Human Body

Istrate

Vololeniuc

Munteanu

et al. 2018

IOP Conf. Ser.: Mater. Sci. Eng.

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Abstract. Based on the biodegradable biomaterial development, there are numerous studies demonstrating partial or total aspects that have ultimately led to their use in many fields, especialy in medicine. This study summarizes the latest information on the development of degradable biomaterials based on magnesium, especially used in in vivo tissue compatibility assessment. The biomaterial compatibility assessment combines with the development of medical devices, this study following evolutionary parameters and integration of implants for human use. One of the most important parameters is the efficiency with which the medical device works near to the maximum potential. In conclusion, our study aims to broadly present the in vivo analysis of biodegradable biomaterials based on magnesium.

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In vitro and in vivo studies on biodegradable magnesium alloy

Cited by 50 publications

References 21 publications

In vivo monitoring the biodegradation of magnesium alloys with an electrochemical H2 sensor

In vivo monitoring the biodegradation of magnesium alloys with an electrochemical H2 sensor

Development of magnesium implants by application of conjoint‐based quality function deployment

Topical Notions About in Vivo Analysis for Degradable Biomaterials with Utility in Human Body

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