In vitro alpha-amylase inhibition and in vivo antioxidant potential of Amaranthus spinosus in alloxan-induced oxidative stress in diabetic rats

Kumar, Balasubramanian; Lakshman, K.; Nandeesh, R.; Kumar, Prem; Manoj, B.; Kumar, Vinod; Shekar, Devangam Sheshadri

doi:10.1016/j.sjbs.2010.08.002

Cited by 44 publications

(14 citation statements)

References 21 publications

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“…in rats: aqueous extract of Pouteria sapota seeds [ 122 ], methanol extract of Martynia annua leaves [ 123 ], ethanol extract of Flourensia cernua leaves [ 124 ], aqueous extract of Enterolobium cyclocarpum bark [ 82 ], ethanol and aqueous extract C. pulcherrima aerial parts [ 125 ], aqueous extract of Passiflora edulis leaves [ 126 ], hydroalcoholic extract of Magnolia grandiflora seeds [ 127 ], and ethanol extract of Crescentia cujete fruits [ 128 ]. The same pattern was also shown in methanol extracts of leaves of Amaranthus spinosus [ 129 ], and Rauvolfia tetraphylla [ 130 ], chloroform-methanol extract of Cnidoscolus chayamansa leaves [ 131 ], aqueous extract of R. humilis fruits [ 132 ], a chloroform fraction from an ethanol extract of Tagetes erecta flowers [ 133 ], aqueous extract of Karwinskia humboldtiana seeds [ 134 ], and hydroalcoholic extract of Senna occidentalis aerial parts [ 135 ], as well as lutein and lutein ester, obtained from Tagetes erecta [ 136 ], and ethanol extract of Jatropha gossypiifolia aerial parts [ 137 ], and aqueous extract of Caladium bicolor [ 138 ].…”

Section: Toxicologysupporting

confidence: 72%

Medicinal Plants from North and Central America and the Caribbean Considered Toxic for Humans: The Other Side of the Coin

Alonso-Castro

Domínguez

Ruiz-Padilla

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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The consumption of medicinal plants has notably increased over the past two decades. People consider herbal products as safe because of their natural origin, without taking into consideration whether these plants contain a toxic principle. This represents a serious health problem. A bibliographic search was carried out using published scientific material on native plants from Mexico, Central America, and the Caribbean, which describe the ethnobotanical and toxicological information of medicinal plants empirically considered to be toxic. A total of 216 medicinal plants belonging to 77 families have been reported as toxic. Of these plants, 76 had been studied, and 140 plants lacked studies regarding their toxicological effects. The toxicity of 16 plants species has been reported in clinical cases, particularly in children. From these plants, deaths have been reported with the consumption of Chenopodium ambrosioides, Argemone mexicana, and Thevetia peruviana. In most of the cases, the principle of the plant responsible for the toxicity is unknown. There is limited information about the toxicity of medicinal plants used in Mexico, Central America, and the Caribbean. More toxicological studies are necessary to contribute information about the safe use of the medicinal plants cited in this review.

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Section: Toxicologysupporting

confidence: 72%

Medicinal Plants from North and Central America and the Caribbean Considered Toxic for Humans: The Other Side of the Coin

Alonso-Castro

Domínguez

Ruiz-Padilla

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…A further increment in dose (500 mg/kg) decreased the fecal output possibly due to the presence of spasmolytic component along with spasmogenic constituents. In addition, there are multiple reports showing the safety of plant administration in experimental animals at around 4 times higher doses than the highest dose tested in this study [32,33]. …”

Section: Discussionmentioning

confidence: 95%

Evaluation of gut modulatory and bronchodilator activities of Amaranthus spinosus Linn.

Chaudhary

Imran

Bashir

et al. 2012

BMC Complement Altern Med

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BackgroundThe aqueous-methanolic extract of Amaranthus spinosus (A. spinosus Linn.,) whole plant, was studied for its laxative, spasmolytic and bronchodilator activities to validate some of its medicinal uses.MethodsThe crude extract of A. spinosus was studied in-vivo for bronchodilator and laxative activities and in-vitro using isolated tissue preparations which were mounted in tissue baths assembly containing physiological salt solutions, maintained at 37°C and aerated with carbogen, to assess the spasmolytic effect and to find out the possible underlying mechanisms.ResultsIn the in-vivo experiments in mice, the administration of A. spinosus increased fecal output at doses of 100 and 300 mg/kg showing laxative activity. It also inhibited carbachol-induced bronchospasm in anesthetized rats at 1, 3, 10 and 30 mg/kg indicative of bronchodilator activity. When tested on isolated gut preparations, the plant extract showed a concentration-dependent (0.01-10.0 mg/ml) spasmogenic effect in spontaneously contracting rabbit jejunum and guinea-pig ileum. The spasmogenic effect was partially blocked in tissues pretreated with atropine (0.1 μM). When tested on K+ (80 mM)-induced sustained contractions in isolated rabbit jejunum, the plant extract caused complete relaxation and also produced a shift in the Ca++ concentration-response curves (CRCs) towards right, similar to diltiazem. In rabbit trachea, the plant extract completely inhibited K+ (80 mM) and carbachol (CCh, 1 μM)-induced contractions at 1 mg/ml but pretreatment of tissue with propranolol (1 μM), caused around 10 fold shift in the inhibitory CRCs of the plant extract constructed against CCh-induced contraction. The plant extract (up to 0.3 mg/ml) also increased both force and rate of spontaneous contractions of isolated guinea-pig atria, followed by relaxation at higher concentration (1.0-5.0 mg/ml). The cardio-stimulant effect was abolished in the presence of propranolol, similar to that of isoprenaline. Activity-directed fractionation revealed that the spasmolytic component(s) was separated in the organic fraction, whereas the spasmogenic component was concentrated in the aqueous fraction.ConclusionThese results indicate that A. spinosus possesses laxative activity partially mediated through cholinergic action. The spasmolytic effect was mediated through calcium channel blocking (CCB), while bronchodilator activity through a combination of β-adrenergic and CCB pathways, which may explain the traditional uses of A. spinosus in gut and airways disorders.

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“…The betalains in the stem of Amaranthus spinosus L include amaranthin, isoamaranthine, hydroxycinnamates, rutin, quercetin and kaempferol glycosides [43]. It has also contains amaranthoside, a lignan glycoside;…”

Section: Amaranthus Spinosus Lmentioning

confidence: 99%

“…amaricin, a coumaroyl adenosine, stigmasterol glycoside, and betaines such as glycinebetaine and trigonelline [44]. Betalains are wellknown anti-oxidants, anti-cancer, antiviral and anthelmintic agents [39,43,[45][46][47] (Figure 1).…”

Section: Amaranthus Spinosus Lmentioning

confidence: 99%

Review on Some Malaysian Traditional Medicinal Plants with Therapeutic Properties

Alsarhan

Sultana

Alkhatib

et al. 2021

J. Basic Appl. Sci.

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There are many medicinal plants that have been used for thousands of years. These plants can now be found in herbal products and as part of the traditional Malaysian health care system because of their therapeutic efficacy. This paper discusses the use of ten medicinal plants in the traditional medicinal system of Malaysia and related scientific studies on their Pharmaceutical properties, which demonstrate their traditional uses. The plants viewed are Amaranthus spinosus L.

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In vitro alpha-amylase inhibition and in vivo antioxidant potential of Amaranthus spinosus in alloxan-induced oxidative stress in diabetic rats

Cited by 44 publications

References 21 publications

Medicinal Plants from North and Central America and the Caribbean Considered Toxic for Humans: The Other Side of the Coin

Medicinal Plants from North and Central America and the Caribbean Considered Toxic for Humans: The Other Side of the Coin

Evaluation of gut modulatory and bronchodilator activities of Amaranthus spinosus Linn.

Review on Some Malaysian Traditional Medicinal Plants with Therapeutic Properties

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