In utero exposure to endocrine-disrupting chemicals, maternal factors and alterations in the epigenetic landscape underlying later-life health effects

Lite, Christy; Raja, Glancis Luzeena; Juliet, Melita; Sridhar, Vasisht Varsh; Subhashree, K. Divya; Kumar, Praveen; Chakraborty, Paromita; Arockiaraj, Jesu

doi:10.1016/j.etap.2021.103779

Cited by 25 publications

(26 citation statements)

References 244 publications

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“…In our study, AChE activity was greatly reduced in 10 PPB of BP and PP exposed zebrafish larvae. Similar to the current study results, Raja et al, in 2018 reported suppressed AChE activity along with increased anxiety‐like behavior in zebrafish larvae exposed to methyparaben 28,29,95 …”

Section: Discussionsupporting

confidence: 91%

“…Similar to the current study results, Raja et al, in 2018 reported suppressed AChE activity along with increased anxiety-like behavior in zebrafish larvae exposed to methyparaben. 28,29,95 In this study, the NO content was found to be significantly increased in the 1 PPB and 10 PPB of BP and PP exposure groups.…”

Section: Discussionsupporting

confidence: 51%

“…Previous studies from our lab showed early exposure to methylparaben to induce developmental toxicity in zebrafish and increased expression of estrogen‐responsive gene: vitellogenin I (Vtg‐I). Vtg‐I is considered to be a sensitive biomarker for detecting exposure to estrogenic EDCs 27,28 . Our lab has also reported increase anxiety‐like behavior in zebrafish larvae which are embryonically exposed to sub‐lethal concentrations of methylparaben 29 …”

Section: Introductionmentioning

confidence: 88%

“…Vtg-I is considered to be a sensitive biomarker for detecting exposure to estrogenic EDCs. 27,28 Our lab has also reported increase anxiety-like behavior in zebrafish larvae which are embryonically exposed to sublethal concentrations of methylparaben. 29 The neurobehavioral changes in zebrafish are considered to be a sensitive measure to assess the functioning of the neural networks in the brain.…”

Section: Introductionmentioning

confidence: 92%

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Embryonic exposure to butylparaben and propylparaben induced developmental toxicity and triggered anxiety‐like neurobehavioral response associated with oxidative stress and apoptosis in the head of zebrafish larvae

Lite

Guru

Juliet

et al. 2022

Environmental Toxicology

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Parabens are synthetic antimicrobial compounds used as a preservative for extending the shelf life of food, pharmaceutical and cosmetic products. The alkyl chain length of the paraben esters positively correlates with their antimicrobial property. Hence, long-chain paraben esters, namely butylparaben and propylparaben, are used in combination as they have better solubility and antimicrobial efficacy. Extensive use of parabens has now resulted in the ubiquitous presence of these compounds in various human and environmental matrices. During early life, exposure to environmental contaminants is known to cause oxidative-stress mediated apoptosis in developing organs. The brain being one of the high oxygen-consuming, metabolically active and lipid-rich organ, it is primarily susceptible to reactive oxygen species (ROS) and lipid peroxidation (LP) induced neuronal cell death. The primary cause for the impairment in cognitive and emotional neurobehvioural outcomes in neurodegenerative disease was found to be associated with neuronal apoptosis. The present study aimed to study butylparaben and propylparaben's effect on zebrafish during early embryonic stages. Besides this, the association between alteration in anxiety-like neurobehavioral response with oxidative stress and antioxidant status in head region was also studied. The study results showed variation in the toxic signature left by butylparaben and propylparaben on developmental parameters such as hatching rate, survival and non-lethal malformations in a time-dependent manner. Data from the light-dark preference test showed embryonic exposure to butylparaben and propylparaben to trigger anxiety-like behavior in zebrafish larvae. In addition, a significant increase in intracellular ROS and LP levels correlated with suppressed antioxidant enzymes: superoxide dismutases (SOD), catalases (CAT), Glutathione peroxidase (GPx), glutathione S-transferase (GST), and Glutathione (GSH) activity in the head region of the zebrafish larvae. Acetylcholinesterase (AChE) activity was also suppressed in the exposed groups, along with increased nitric oxide production. The overall observations show increased oxidative stress indices correlating with upregulated expression of apoptotic cells in a dose-dependent manner. Collectively, our findings reveal butylparaben and propylparaben as an anxiogenic neuroactive Christy Lite, Ajay Guru, and Melita Juliet contributed equally to this study.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 51%

Section: Introductionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 92%

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Embryonic exposure to butylparaben and propylparaben induced developmental toxicity and triggered anxiety‐like neurobehavioral response associated with oxidative stress and apoptosis in the head of zebrafish larvae

Lite

Guru

Juliet

et al. 2022

Environmental Toxicology

Self Cite

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“…Thus, human beings face a new challenge due to the high risk of adverse health outcomes. Currently, the United States Environmental Protection Agency (EPA) and EU have restricted the use of chemicals suspected of causing harm to human health, as well as to farm animals and wildlife, groundwater, or the atmosphere [47,48]. The investigations conducted so far have established that prolonged exposure to EDs affects negatively the endocrine system, as well as growth and postnatal development, compromising with epigenetic mechanisms of morphogenetic events [34,49].…”

Section: Discussionmentioning

confidence: 99%

Toxic Effects of Endocrine Disruptor Exposure on Collagen-Induced Arthritis

et al. 2022

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Endocrine disruptors (EDs) are chemical substances capable of affecting endocrine system functioning and interfering with organ morphogenesis and physiological functions. The development and regeneration of bone tissues have a complex hormonal regulation, and therefore, bone tissue cells can be considered potential targets for endocrine disruptors. In that regard, the aim of this research was to investigate the impact of ED exposure on the inflammatory response and oxidative stress in an experimental model of collagen-induced arthritis (CIA). Arthritis was induced by an emulsion of type II collagen (CII) and complete Freund’s adjuvant, which was administered intradermally on days 0 and 21. Mice from day 21 to day 35 received the following EDs by oral gavage: cypermethrin (CP), diethyl phthalate (DEP), vinclozolin (VCZ), 17α-ethinylestradiol (EE), perfluorooctanesulfonic acid (PFOS) and atrazine (ATR). ED exposure caused worsening of clinical signs (erythema and edema in the hind paws), histological and radiographic changes, as well as behavioral deficits, induced by CII injections. Furthermore, ED exposure significantly increased the degree of inflammation and oxidative damage induced by arthritis; this upregulation was more evident after exposure to ATR than to other EDs. The results from our study suggest that exposure to EDs may play a deleterious role in the progression of RA; therefore, exposure to EDs should be limited.

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EDCs: Focus on reproductive alterations in mammalian and nonmammalian models

Maradonna¹,

Meccariello²

2023

Environmental Contaminants and Endocrine Health

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In utero exposure to endocrine-disrupting chemicals, maternal factors and alterations in the epigenetic landscape underlying later-life health effects

Cited by 25 publications

References 244 publications

Embryonic exposure to butylparaben and propylparaben induced developmental toxicity and triggered anxiety‐like neurobehavioral response associated with oxidative stress and apoptosis in the head of zebrafish larvae

Embryonic exposure to butylparaben and propylparaben induced developmental toxicity and triggered anxiety‐like neurobehavioral response associated with oxidative stress and apoptosis in the head of zebrafish larvae

Toxic Effects of Endocrine Disruptor Exposure on Collagen-Induced Arthritis

EDCs: Focus on reproductive alterations in mammalian and nonmammalian models

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