EDCs: Focus on reproductive alterations in mammalian and nonmammalian models

Maradonna, Francesca; Meccariello, Rosaria

doi:10.1016/b978-0-12-824464-7.00003-9

Cited by 2 publications

(1 citation statement)

References 156 publications

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“…A vast body of the literature exists concerning the reproductive toxicity exerted by these pollutants on gametogenesis progression, gamete quality, and reproductive efficiency. Over the years, the findings have been summarized in numerous reviews [ 157 , 158 , 159 , 160 , 161 , 162 , 163 ].…”

Section: The Use Of Model Species To Investigate Reproductive Challen...mentioning

confidence: 99%

A Pretty Kettle of Fish: A Review on the Current Challenges in Mediterranean Teleost Reproduction

Lombó,

Giommi,

Zarantoniello

et al. 2024

Animals

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The Mediterranean region is facing several environmental changes and pollution issues. Teleosts are particularly sensitive to these challenges due to their intricate reproductive biology and reliance on specific environmental cues for successful reproduction. Wild populations struggle with the triad of climate change, environmental contamination, and overfishing, which can deeply affect reproductive success and population dynamics. In farmed species, abiotic factors affecting reproduction are easier to control, whereas finding alternatives to conventional diets for farmed teleosts is crucial for enhancing broodstock health, reproductive success, and the sustainability of the aquaculture sector. Addressing these challenges involves ongoing research into formulating specialized diets, optimizing feeding strategies, and developing alternative and sustainable feed ingredients. To achieve a deeper comprehension of these challenges, studies employing model species have emerged as pivotal tools. These models offer advantages in understanding reproductive mechanisms due to their well-defined physiology, genetic tractability, and ease of manipulation. Yet, while providing invaluable insights, their applicability to diverse species remains constrained by inherent variations across taxa and oversimplification of complex environmental interactions, thus limiting the extrapolation of the scientific findings. Bridging these gaps necessitates multidisciplinary approaches, emphasizing conservation efforts for wild species and tailored nutritional strategies for aquaculture, thereby fostering sustainable teleost reproduction in the Mediterranean.

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Section: The Use Of Model Species To Investigate Reproductive Challen...mentioning

confidence: 99%

A Pretty Kettle of Fish: A Review on the Current Challenges in Mediterranean Teleost Reproduction

Lombó,

Giommi,

Zarantoniello

et al. 2024

Animals

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PLASTAMINATION: Outcomes on the Central Nervous System and Reproduction

Santoro,

Marino,

Vandenberg

et al. 2024

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Background: Environmental exposures to non-biodegradable and biodegradable plastics are unavoidable. Microplastics (MPs) and nanoplastics (NPs) from the manufacturing of plastics (primary sources) and the degradation of plastic waste (secondary sources) can enter the food chain directly or indirectly and, passing biological barriers, could target both the brain and the gonads. Hence, the worldwide diffusion of environmental plastic contamination (PLASTAMINATION) in daily life may represent a possible and potentially serious risk to human health. Objective: This review provides an overview of the effects of non-biodegradable and the more recently introduced biodegradable MPs and NPs on the brain and brain-dependent reproductive functions, summarizing the molecular mechanisms and outcomes on nervous and reproductive organs. Data from in vitro, ex vivo, non-mammalian and mammalian animal models and epidemiological studies have been reviewed and discussed. Results: MPs and NPs from non-biodegradable plastics affect organs, tissues and cells from sensitive systems such as the brain and reproductive organs. Both MPs and NPs induce oxidative stress, chronic inflammation, energy metabolism disorders, mitochondrial dysfunction and cytotoxicity, which in turn are responsible for neuroinflammation, dysregulation of synaptic functions, metabolic dysbiosis, poor gamete quality, and neuronal and reproductive toxicity. In spite of this mechanistic knowledge gained from studies of non-biodegradable plastics, relatively little is known about the adverse effects or molecular mechanisms of MPs and NPs from biodegradable plastics. Conclusion: The neurological and reproductive health risks of MPs/NPs exposure warrant serious consideration, and further studies on biodegradable plastics are recommended.

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EDCs: Focus on reproductive alterations in mammalian and nonmammalian models

Cited by 2 publications

References 156 publications

A Pretty Kettle of Fish: A Review on the Current Challenges in Mediterranean Teleost Reproduction

A Pretty Kettle of Fish: A Review on the Current Challenges in Mediterranean Teleost Reproduction

PLASTAMINATION: Outcomes on the Central Nervous System and Reproduction

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