In the Quest of a Standard Index of Intrinsic Capacity. A Critical Literature Review

González-Bautista, Emmanuel; Andrieu, Sandrine; Gutiérrez‐Robledo, Luis Miguel; García-Chanes, R. E.; Barreto, Philipe de Souto

doi:10.1007/s12603-020-1394-4

Cited by 21 publications

(6 citation statements)

References 41 publications

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“…A general IC index, rather than simple effects of different subdomains added together, may provide better predicted value. Thus far, no global IC index has been validated for clinical or research purposes [ 14 ]. Therefore, more research on the validation of IC concepts and constructs is required, along with further quantitative evaluation of IC and its domains in different settings.…”

Section: Healthy Aging and Intrinsic Capacitymentioning

confidence: 99%

Intrinsic Capacity in Older Adults: Recent Advances

Zhou

2022

Aging and disease

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Section: Healthy Aging and Intrinsic Capacitymentioning

confidence: 99%

Intrinsic Capacity in Older Adults: Recent Advances

Zhou

2022

Aging and disease

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“…In the WHO Integrated Care for Older People, IC consists of five elements, i.e., locomotion, sensory, vitality, psychological, and cognition, which represent the physiological competence of individuals to support their FA [1]. Although there are strong theoretical and consensual bases to support this multidomain conceptualization of IC [5][6][7][8], most empirical studies have focused on the associations between IC and disability [4,9], falls [10], quality of life [11], and mortality [12][13][14]. Unique diet, lifestyle, culture and policy may interact with IC, and contribute to FA, particularly in Asia [8].…”

Section: Introductionmentioning

confidence: 99%

Intrinsic capacity differs from functional ability in predicting 10-year mortality and biological features in healthy aging: results from the I-Lan longitudinal aging study

Lee

Peng

Lin

et al. 2023

Aging

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This study aimed to explore the biological features and mortality risk of intrinsic capacity (IC) and functional ability (FA). Based on data from 1839 participants from the I-Lan Longitudinal Aging Study, multivariable Cox proportional hazard models were used to evaluate the predictive ability of IC (range 0-100) and FA (range 0-100) on 10-year mortality. Of 2038 repeated measurements for IC within a 7-year observational period, multivariable logistic regression was used to compare biological features of participants with maintained, improved and rapidly deteriorated IC. A 1-point increased IC value was associated with a 5% (HR 0.95, 95% CI 0.93-0.97, p < 0.001) decrease in mortality risk. Low IC (HR 1.94, 95% CI 1.39-2.70, p < 0.001) was associated with higher mortality risk. Hyperglycemia (OR 1.40, 95% CI 1.09-1.81, p = 0.010), low serum levels of DHEA-S (OR 3.33, 95% CI 1.32-8.41, p = 0.011), and high serum levels of C-reactive protein (OR 1.45, 95% CI 1.05-2.00, p = 0.023) were associated with low IC at baseline. Low serum levels of DHEA-S (middle tertile OR 1.84, 95% CI 1.15-2.95, p = 0.012; lowest tertile OR 2.25, 95% CI 1.34-3.77, p = 0.002) and vitamin D deficiency (OR 1.82, 95% CI 1.02-3.27, p = 0.044) were associated with rapid deterioration of IC. IC and FA predicted 10-year mortality, whereas chronic inflammation, hyperglycemia, and low DHEA-S were associated with low IC status. Low DHEA-S and vitamin D deficiency may be considered as potential biomarkers of rapid IC declines, which implies underlying biological mechanisms of healthy aging.

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“…These domains were identified as the body and mind functions associated with a higher risk of adverse health outcomes such as disability, frailty, care dependency, and mortality ( 2 ). Although there is no consensus on a standard index of IC ( 3 ), the indicators used generally follow this 2-domain structure. There is also no agreement on the generation of a total score of IC, with many models only producing domain-specific scores ( 3 ).…”

mentioning

confidence: 99%

“…Although there is no consensus on a standard index of IC ( 3 ), the indicators used generally follow this 2-domain structure. There is also no agreement on the generation of a total score of IC, with many models only producing domain-specific scores ( 3 ). In an early model of IC, Beard et al used confirmatory factor analysis (CFA) to generate a bifactor model of IC and extract a score for the general IC factor ( 4 ), while others have used composite z -scores ( 5 , 6 ) and summing of item scores or impairments ( 7 , 8 ).…”

mentioning

confidence: 99%

Operationalization of Intrinsic Capacity in Older People and Its Association With Subsequent Disability, Hospital Admission and Mortality: Results From The English Longitudinal Study of Ageing

Campbell

Cadar

McMunn

et al. 2022

The Journals of Gerontology: Series A

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Background Intrinsic capacity (IC) is a new concept in the healthy ageing field and has many operationalised definitions. In this study, we operationalised IC using item response theory in the English Longitudinal Study of Ageing (ELSA) and tested the predictive value of the scale using subsequent functional ability, mortality, and hospital admission. Methods IC was measured at baseline (2004, Wave 2) using 14 dichotomous indicators: word recall, orientation in time, balance, chair rises, walking speed, upper mobility, lower mobility, eyesight, hearing, grip strength, BMI, waist circumference, depressive symptoms, life satisfaction. A two-parameter item response theory model was used to generate a scale of IC at baseline. Logistic regression was used for the prediction of subsequent difficulties, measured by difficulties with ≥1 activities of daily living (ADLs) and ≥1 instrumental activities of daily living (IADLs) at 4 and 8 years after baseline. Competing risk and cox regressions were employed to test prediction of hospital admission and mortality, respectively, over a 14-year follow-up. Results Intrinsic capacity scores were generated for 4,545 individuals aged on average 70.8 years (SD 7.93). Better baseline IC scores were associated with reduced risk of subsequent difficulties with ADLs and IADLs, hospital admission (SHR=0.99, 95%CI 0.98-0.99) and mortality (HR=0.98, 95%CI 0.98–0.99), when adjusted for sociodemographic and health-related covariates. Conclusions These results suggest the utility of this IC score as a measure of risk for future adverse outcomes in older people, potentially above that indicated by other sociodemographic and health-related factors.

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In the Quest of a Standard Index of Intrinsic Capacity. A Critical Literature Review

Cited by 21 publications

References 41 publications

Intrinsic Capacity in Older Adults: Recent Advances

Intrinsic Capacity in Older Adults: Recent Advances

Intrinsic capacity differs from functional ability in predicting 10-year mortality and biological features in healthy aging: results from the I-Lan longitudinal aging study

Operationalization of Intrinsic Capacity in Older People and Its Association With Subsequent Disability, Hospital Admission and Mortality: Results From The English Longitudinal Study of Ageing

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