In situ synthesis of graphene oxide/gold nanorods theranostic hybrids for efficient tumor computed tomography imaging and photothermal therapy

Sun, Baozhi; Wu, Jinrui; Cui, Shaobin; Zhu, Huanhuan; Wei, Anhua; Fu, Qiwei; Shao, Chengwei; Yao, Aihua; Chen, Bingdi; Shi, Donglu

doi:10.1007/s12274-016-1264-x

Cited by 66 publications

(29 citation statements)

References 44 publications

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“…2,3 The development of nanotheranostic agents can be classified into two categories: inorganic and organic. 4 Inorganic nanotheranostic agents, including noble metals, 5,6 semiconductor NPs, 7,8 and carbon materials, [9][10][11] are studied extensively, as they are highly stable and have multifunctional properties. However, inorganic materials do not degrade, and long-term retention in the body limits their clinical use for cancer treatments, 12 since agents must completely clear the body within a reasonable period to receive regulatory approval from the US Food and Drug Administration (FDA).…”

Section: Introductionmentioning

confidence: 99%

BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics

Mu¹,

Yan²,

Tian³

et al. 2017

IJN

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Protein-related nanotheranostic agents hold great promise as tools to serve many clinical applications. Proteins such as BSA are used to regulate the synthesis of nondegradable inorganic nanoparticles (NPs). To fully employ the potential of such proteins, a new type of biosafe nanotheranostic agent must be designed to optimize BSA as a biomineralization agent. Here, a straightforward BSA-assisted biomineralization method was developed to prepare gallic acid (GA)–Fe(III) coordination polymer NPs. BSA-coated GA-Fe (GA-Fe@BSA) NPs were ultrasmall (3.5 nm) and showed good biocompatibility, a lower r 2 : r 1 ratio (1.06), and strong absorption in the visible near-infrared region. T 1 -weighted magnetic resonance imaging of tumor-bearing mice before and after intratumoral injection with GA-Fe@BSA NPs definitively demonstrated positive change. In a subsequent in vivo study, antitumor activity was precipitated by intratumoral injection of GA-Fe@BSA NPs combined with laser treatment, suggesting excellent outcomes with this treatment method. These results describe a successful protocol in which BSA regulated the synthesis of benign organic polymer NPs. GA-Fe@BSA NPs have the potential to be ideal agents to be used in clinical theranostic nanoplatforms.

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Section: Introductionmentioning

confidence: 99%

BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics

Mu¹,

Yan²,

Tian³

et al. 2017

IJN

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“…In this study, we proposed a new theranostic platform based on thiolated reduced graphene oxide and integrated with plasmonic spherical and rod-like gold nanoparticles. To the best of our knowledge, although several examples exist in literature on AuNP-decorated GO nanocomposites obtained by in situ growth methods, including green approaches [24,68,69], only few studies have focused on the functionalization of thiolated GO with gold nanoparticles [70].…”

Section: Introductionmentioning

confidence: 99%

Theranostic Nanoplatforms of Thiolated Reduced Graphene Oxide Nanosheets and Gold Nanoparticles

et al. 2020

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In this study, graphene oxide (GO) and reduced-thiolated GO (rGOSH) were used as 2D substrate to fabricate nanocomposites with nanoparticles of gold nanospheres (AuNS) or nanorods (AuNR), via in situ reduction of the metal salt precursor and seed-mediated growth processes. The plasmonic sensing capability of the gold-decorated nanosheets were scrutinized by UV-visible (UV-VIS) spectroscopy. Attenuated total reflectance Fourier transform infrared spectroscopy (ATR-FTIR), thermogravimetric analyses (TGA), and atomic force microscopy (AFM) were performed in order to prove the actual reduction that occurred concomitantly with the thiolation of GO, the increase in the hydrophobic character as well as the size, and preferential gathering of the gold nanoparticles onto the nanosheet substrates, respectively. Moreover, the theoretical electronic and infrared absorption (UV-VIS and IR) spectra were calculated within a time-dependent approach of density functional theory (DFT). Eventually, in vitro cellular experiments on human neuroblastoma cells (SH-SY5Y line) were carried out in order to evaluate the nanotoxicity of the nanocomposites by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide tetrazolium reduction (MTT) colorimetric assay. Results pointed out the promising potential of these hybrids as plasmonic theranostic platforms with different hydrophilic or hydrophobic features as well as cytotoxic effects against cancer cells.

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“…One of the most popular approaches is straightforward seed growth method in the GO or RGO suspensions, and the defects and residual oxygenated functional groups of GO and RGO were applied as the nucleation sites for the growth of metallic nanorods. Unfortunately, large amount of other gold nanostructures would form into the surface of GO or RGO . Moreover, monodispersity and load rate of the as‐synthesized AuNRs on graphene surface was relatively poor .…”

Section: Introductionmentioning

confidence: 99%

In‐Situ covalent synthesis of gold nanorods on GO surface as ultrasensitive Raman probe

Guo

Geng

et al. 2019

Applied Organom Chemis

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In this paper, using thiolated graphene oxide (GO‐O‐SH) as substrate, gold nanorods (AuNRs) covalently linked to the GO surface by in‐situ seed growth method were first reported. The as‐prepared composites were characterized by UV–vis spectrum, transmission electron microscopy (TEM), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT‐IR). Experimental results indicated that the introduction of short flexible organic chain between GO and AuNRs contributed to the homogenous synthesis of gold rods, and uniform gold nanorods with aspect ratio within 3~8 were covalently linked to the surface of GO with high stability and yield. The strategy represented an outstanding improvement in comparison to the traditional route for fabricating GO@AuNRs composites. Furthermore, based on coupling of the two nanomaterials, the composites could act as high sensitive Raman probe with limit of detection (LOD) reaching 1 × 10−12 M.

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In situ synthesis of graphene oxide/gold nanorods theranostic hybrids for efficient tumor computed tomography imaging and photothermal therapy

Cited by 66 publications

References 44 publications

BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics

BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics

Theranostic Nanoplatforms of Thiolated Reduced Graphene Oxide Nanosheets and Gold Nanoparticles

In‐Situ covalent synthesis of gold nanorods on GO surface as ultrasensitive Raman probe

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In situ synthesis of graphene oxide/gold nanorods theranostic hybrids for efficient tumor computed tomography imaging and photothermal therapy

Cited by 66 publications

References 44 publications

BSA-assisted synthesis of ultrasmall gallic acid&ndash;Fe(III) coordination polymer nanoparticles for cancer theranostics

BSA-assisted synthesis of ultrasmall gallic acid&ndash;Fe(III) coordination polymer nanoparticles for cancer theranostics

Theranostic Nanoplatforms of Thiolated Reduced Graphene Oxide Nanosheets and Gold Nanoparticles

In‐Situ covalent synthesis of gold nanorods on GO surface as ultrasensitive Raman probe

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BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics

BSA-assisted synthesis of ultrasmall gallic acid–Fe(III) coordination polymer nanoparticles for cancer theranostics