In Situ Photopolymerization of Acrylamide Hydrogel to Coat Cellulose Acetate Nanofibers for Drug Delivery System

Abstract

In this study we developed electrospun cellulose acetate nanofibers (CANFs) that were loaded with a model non-steroidal anti-inflammatory drug (NSAID) (ibuprofen, Ib) and coated with poly(acrylamide) (poly-AAm) hydrogel polymer using two consecutive steps: an electrospinning process followed by photopolymerization of AAm. Coated and non-coated CANF formulations were characterized by several microscopic and spectroscopic techniques to evaluate their physicochemical properties. An analysis of the kinetic release profile of Ib showed noticeable differences due to the presence or absence of the poly-AAm hydrogel polymer. Poly-AAm coating facilitated a constant release rate of drug as opposed to a more conventional burst release. The non-coated CANFs showed low cumulative drug release concentrations (ca. 35 and 83% at 5 and 10% loading, respectively). Conversely, poly-AAm coated CANFs were found to promote the release of drug (ca. 84 and 99.8% at 5 and 10% loading, respectively). Finally, the CANFs were found to be superbly cytocompatible.

A green composite hydrogel based on xylan and lignin with adjustable mechanical properties, high swelling, excellent UV shielding, and antioxidation properties

“…Obviously, three curves exhibited the typical absorption peaks of PAM at 3424 and 3167 cm −1 , which is due to the symmetrical and asymmetrical vibrations between the N–H bonds 28 . While the peaks at 2931 and 2783 cm −1 ascribed to the C–H asymmetrical stretching and vibrations in methyl and methylene structures, respectively 29 . And the peak at 1675 cm −1 is assigned to the C=O stretching vibrations 30 .…”

“…28 While the peaks at 2931 and 2783 cm À1 ascribed to the C-H asymmetrical stretching and vibrations in methyl and methylene structures, respectively. 29 And the peak at 1675 cm À1 is assigned to the C=O stretching vibrations. 30 Compared with PAM hydrogel, AL-0 composite hydrogel has characteristic peaks of CMX at 1601 and 920 cm À1 , which attribute to the presence of the COO À group 31 and arabinose units, 32 respectively.…”

Crosslinkers for polysaccharides and proteins: Synthesis conditions, mechanisms, and crosslinking efficiency, a review

“…The polysaccharide radicals attack AAc and MBA vinyl groups, transfering the active centers to these monomers, which can successively react to the neighbor monomers leading to crosslinking and chain propagation [167]. Unlike thermal free-radical polymerization, photopolymerization via MBA can be performed under mild conditions, at room temperature or up to 40 °C [165,[170][171][172].…”

Progress of Research in In Situ Smart Hydrogels for Local Antitumor Therapy: A Review

“…Vigata et al developed a novel GelMA-based hydrogel loaded with paclitaxel-based abraxane for sustained local delivery of paclitaxel and the prevention of local breast cancer recurrence [ 79 ]. In another study, Attia et al developed a method of in situ photopolymerization of acrylamide hydrogel to carry poorly water-soluble drugs [ 81 ]. Luo et al formulated an injectable multifunctional therapeutic-repair-enabled citrate–iron hydrogel (GPDF) for efficient post-surgical skin cancer treatment by photo-crosslinking gelatin/GelMA in the presence of PCG-dopamine (PCD) and Fe 3+ ions with UV irradiation [ 82 ].…”