Crosslinkers for polysaccharides and proteins: Synthesis conditions, mechanisms, and crosslinking efficiency, a review

Alavarse, Alex Carvalho; Frachini, Emilli; Silva, Rafael Leonardo Cruz Gomes da; Lima, Vitoria Hashimoto; Shavandi, Amin; Petri, Denise Freitas Siqueira

doi:10.1016/j.ijbiomac.2022.01.029

Cited by 126 publications

(81 citation statements)

References 345 publications

(432 reference statements)

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“…On the other hand, elastin can be a very efficient biomaterial, due to its unique structure and stability. However, elastin still needs further research to improve it properties once introduced in the body [ 162 , 176 ].…”

Section: Methodsmentioning

confidence: 99%

“…Several well-known reactions, which can be classified into three groups, comply with the “click chemistry” approach for hydrogel manufacture. These three groups include: (1) copper-free click reactions, such as Diels–Alder (DA), strain-promoted azide-alkyne cycloaddition (SPAAC), oxime-forming reactions and radical mediated thiol-ene; (2) copper-catalyzed azide-alkyne cycloaddition (Cu-AAC), and (3) pseudo click reactions, which include aldehyde-hydrazide reactions (Schiff-base reactions) and thiol-Michael addition [ 176 ].…”

Section: Synthesis Of Hydrogelsmentioning

confidence: 99%

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Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

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Nowadays, there are still numerous challenges for well-known biomedical applications, such as tissue engineering (TE), wound healing and controlled drug delivery, which must be faced and solved. Hydrogels have been proposed as excellent candidates for these applications, as they have promising properties for the mentioned applications, including biocompatibility, biodegradability, great absorption capacity and tunable mechanical properties. However, depending on the material or the manufacturing method, the resulting hydrogel may not be up to the specific task for which it is designed, thus there are different approaches proposed to enhance hydrogel performance for the requirements of the application in question. The main purpose of this review article was to summarize the most recent trends of hydrogel technology, going through the most used polymeric materials and the most popular hydrogel synthesis methods in recent years, including different strategies of enhancing hydrogels’ properties, such as cross-linking and the manufacture of composite hydrogels. In addition, the secondary objective of this review was to briefly discuss other novel applications of hydrogels that have been proposed in the past few years which have drawn a lot of attention.

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Section: Methodsmentioning

confidence: 99%

Section: Synthesis Of Hydrogelsmentioning

confidence: 99%

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

et al. 2022

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“…Genipin, enzymes, and citric acid are some of the frequently used natural crosslinkers due to their low toxicity [ 130 ]. These cross-linking agents have improved biodegradability, biocompatibility, and water solubility compared to synthetic crosslinkers and have recently gained much attention to form biocompatible materials, inclusive of other crosslinkers such as gallic acid, ferulic acid, vanillin, flavonoids (catechins, pro-anthocyanidins) and desmosine analogs [ 131 ].…”

Section: Polymers and Cross-linking Agentsmentioning

confidence: 99%

“…The structure of vanillin has an aldehyde group that forms a Schiff base with primary amines which are responsible for hydrogen bonds with hydroxyl or amine groups. Thus, this offers the formation of reversible cross-linked networks and self-healing hydrogels with low-temperature stability that is altered with increased temperature due to breaking hydrogen bonds [ 130 ]. Vanillin is a popular flavouring agent widely used in areas such as food, beverages, perfumery, and pharmaceutical industries.…”

Section: Polymers and Cross-linking Agentsmentioning

confidence: 99%

A Comprehensive Review of Cross-Linked Gels as Vehicles for Drug Delivery to Treat Central Nervous System Disorders

Mashabela

Maboa

Miya

et al. 2022

Gels

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Gels are attractive candidates for drug delivery because they are easily producible while offering sustained and/or controlled drug release through various mechanisms by releasing the therapeutic agent at the site of action or absorption. Gels can be classified based on various characteristics including the nature of solvents used during preparation and the method of cross-linking. The development of novel gel systems for local or systemic drug delivery in a sustained, controlled, and targetable manner has been at the epitome of recent advances in drug delivery systems. Cross-linked gels can be modified by altering their polymer composition and content for pharmaceutical and biomedical applications. These modifications have resulted in the development of stimuli-responsive and functionalized dosage forms that offer many advantages for effective dosing of drugs for Central Nervous System (CNS) conditions. In this review, the literature concerning recent advances in cross-linked gels for drug delivery to the CNS are explored. Injectable and non-injectable formulations intended for the treatment of diseases of the CNS together with the impact of recent advances in cross-linked gels on studies involving CNS drug delivery are discussed.

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“…The covalent cross‐linking of protein makes the emulsification, emulsification stability, water retention, gelation ability, and printability of meat emulsion effectively improved. Therefore, MTGase also has positive significance in 3D food printing of meat products (Liu et al ., 2021; Alavarse et al ., 2022).…”

Section: The Potential Extrusion Of 3d Food Printing In Manned Spacef...mentioning

confidence: 99%

Application and challenges of 3D food printing technology in manned spaceflight: a review

Zhang

Dong

Yu³

et al. 2022

Int J of Food Sci Tech

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Three-dimensional (3D) food printing is a digital food engineering method that has a remarkable application potential in long-term manned spaceflight. Extrusion-based 3D food printing, among the available 3D food printing techniques utilised in the food industry, is one of the most suitable printing methods for manned spaceflight. Extrusion-based 3D food printing could suffice most of the energy and personalised nutritional requirements of astronauts during long-term stay in space by utilising fruits, vegetables, meat products, and nutrients as printing materials. However, 3D food printing in manned spaceflight is still limited by technologies and costs such as printing materials, microgravity, post-processability of food, and engineering transportation under the existing technical conditions. Therefore, this article reviews the 3D food printing and manned spaceflight technologies that are currently available and discusses the challenges involved in 3D food printing in manned spaceflight, thus providing a theoretical basis for future 3D food printing for space missions.

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Crosslinkers for polysaccharides and proteins: Synthesis conditions, mechanisms, and crosslinking efficiency, a review

Cited by 126 publications

References 345 publications

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

Novel Trends in Hydrogel Development for Biomedical Applications: A Review

A Comprehensive Review of Cross-Linked Gels as Vehicles for Drug Delivery to Treat Central Nervous System Disorders

Application and challenges of 3D food printing technology in manned spaceflight: a review

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