In situ hydrogel dressing loaded with heparin and basic fibroblast growth factor for accelerating wound healing in rat

Jia, Peng; Zhao, Hui; Tu, Chengzhao; Xu, Zeqin; Ye, Lin; Zhao, Liang; Gu, Zongheng; Zhao, Dong; Zhang, Jie; Feng, Zeng‐guo

doi:10.1016/j.msec.2020.111169

Cited by 80 publications

(49 citation statements)

References 60 publications

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“…The purpose of this research is to create a material accelerating wound healing that does not create an immune response from the patient. The ideal solution would be to create a biomaterial with properties similar to those of the organ it is intended to replace or support [9]. Conventional materials for dentures used for many years are metals.…”

Section: Introductionmentioning

confidence: 99%

Collagen-Based Materials Modified by Phenolic Acids—A Review

Kaczmarek

Mazur

2020

Materials

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Collagen-based biomaterials constitute one of the most widely studied types of materials for biomedical applications. Low thermal and mechanical parameters are the main disadvantages of such structures. Moreover, they present low stability in the case of degradation by collagenase. To improve the properties of collagen-based materials, different types of cross-linkers have been researched. In recent years, phenolic acids have been studied as collagen modifiers. Mainly, tannic acid has been tested for collagen modification as it interacts with a polymeric chain by strong hydrogen bonds. When compared to pure collagen, such complexes show both antimicrobial activity and improved physicochemical properties. Less research reporting on other phenolic acids has been published. This review is a summary of the present knowledge about phenolic acids (e.g., tannic, ferulic, gallic, and caffeic acid) application as collagen cross-linkers. The studies concerning collagen-based materials with phenolic acids are summarized and discussed.

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Section: Introductionmentioning

confidence: 99%

Collagen-Based Materials Modified by Phenolic Acids—A Review

Kaczmarek

Mazur

2020

Materials

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“…However, these results clearly indicate that the extent of revascularization following VML still needs to be improved. Recent work by our lab and others has shown that incorporation of heparin into hydrogels can sequester soluble growth factors and greatly improve angiogenic outcomes 15,70,71 . As a result, future experiments could look to augment revascularization through the addition of bioactive components to the hydrogel system.…”

Section: Discussionmentioning

confidence: 99%

Photoreactive hydrogel stiffness influences volumetric muscle loss repair

Basurto

Passipieri

Gardner

et al. 2021

Preprint

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Volumetric muscle loss (VML) injuries are characterized by permanent loss of muscle mass, structure, and function. Hydrogel biomaterials provide an attractive platform for skeletal muscle tissue engineering due to the ability to easily modulate their biophysical and biochemical properties to match a range of tissue characteristics. In this work we successfully developed a mechanically tunable hyaluronic acid (HA) hydrogel system to investigate the influence of hydrogel stiffness on VML repair. HA was functionalized with photoreactive norbornene groups to create hydrogel networks that rapidly crosslink via thiol-ene click chemistry with tailored mechanics. Mechanical properties were controlled by modulating the amount of matrix metalloproteinase (MMP)-degradable peptide crosslinker to produce hydrogels with increasing elastic moduli of 1.1 ± 0.002, 3.0 ± 0.002, and 10.6 ± 0.006 kPa mimicking a relevant range of developing and mature muscle stiffnesses. Functional muscle recovery was assessed following implantation of the HA hydrogels by in situ photopolymerization into rat latissimus dorsi (LD) VML defects at 12 and 24 weeks post-injury. After 12 weeks, muscles treated with medium stiffness (3.0 kPa) hydrogels produced maximum isometric forces most similar to contralateral healthy LD muscles. This trend persisted at 24 weeks post-injury, suggestive of sustained functional recovery. Histological analysis revealed a significantly larger zone of regeneration with more de novo muscle fibers following implantation of medium stiffness hydrogels in VML-injured muscles compared to other experimental groups. Lower (low and medium) stiffness hydrogels also appeared to attenuate the chronic inflammatory response characteristic of VML injuries, displaying similar levels of macrophage infiltration and polarization to healthy muscle. Together these findings illustrate the importance of hydrogel mechanical properties in supporting functional repair of VML injuries.

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“…Nanotechnologies have been used in dressings for growth factor incorporation, ameliorating growth factors bioavailability and stability. According experimental studies, EGF and FGF- incorporated dressings accelerate angiogenesis, extracellular matrix remodeling and re-epithelialization, with great potential in skin wound treatment [ 87 , 88 , 89 , 90 , 91 , 92 ].…”

Section: Wound Treatmentsmentioning

confidence: 99%

Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies

Gushiken

Beserra

Bastos

et al. 2021

Life

125

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The skin is the biggest organ of human body which acts as a protective barrier against deleterious agents. When this barrier is damaged, the organism promotes the healing process with several molecular and cellular mechanisms, in order to restore the physiological structure of the skin. The physiological control of wound healing depends on the correct balance among its different mechanisms. Any disruption in the balance of these mechanisms can lead to problems and delay in wound healing. The impairment of wound healing is linked to underlying factors as well as aging, nutrition, hypoxia, stress, infections, drugs, genetics, and chronic diseases. Over the years, numerous studies have been conducted to discover the correct approach and best therapies for wound healing, including surgical procedures and non-surgical treatments such as topical formulations, dressings, or skin substitutes. Thus, this general approach is necessary to facilitate the direction of further studies. This work provides updated concepts of physiological mechanisms, the factors that can interfere, and updated treatments used in skin wound healing.

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In situ hydrogel dressing loaded with heparin and basic fibroblast growth factor for accelerating wound healing in rat

Cited by 80 publications

References 60 publications

Collagen-Based Materials Modified by Phenolic Acids—A Review

Collagen-Based Materials Modified by Phenolic Acids—A Review

Photoreactive hydrogel stiffness influences volumetric muscle loss repair

Cutaneous Wound Healing: An Update from Physiopathology to Current Therapies

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