Collagen-Based Materials Modified by Phenolic Acids—A Review

Abstract

Collagen-based biomaterials constitute one of the most widely studied types of materials for biomedical applications. Low thermal and mechanical parameters are the main disadvantages of such structures. Moreover, they present low stability in the case of degradation by collagenase. To improve the properties of collagen-based materials, different types of cross-linkers have been researched. In recent years, phenolic acids have been studied as collagen modifiers. Mainly, tannic acid has been tested for collagen modification as it interacts with a polymeric chain by strong hydrogen bonds. When compared to pure collagen, such complexes show both antimicrobial activity and improved physicochemical properties. Less research reporting on other phenolic acids has been published. This review is a summary of the present knowledge about phenolic acids (e.g., tannic, ferulic, gallic, and caffeic acid) application as collagen cross-linkers. The studies concerning collagen-based materials with phenolic acids are summarized and discussed.

Evaluation of Polymeric Matrix Loaded with Melatonin for Wound Dressing

“…It is obtained mainly from fungi, fish skin, scales, but also from the rat tail, pig or beef tissues, sea sponges, jellyfish, and egg capsules of the dogfish. Collagen isolated from different sources differs in terms of denaturation temperatures, e.g., approximately 33 °C and 39 °C for fish and rat collagen, respectively [ 56 ].…”

The Physicochemical and Antibacterial Properties of Chitosan-Based Materials Modified with Phenolic Acids Irradiated by UVC Light

“…Various polyphenols had been already studied as chitosan crosslinkers as tannic acid [ 10 ], gallic acid [ 11 ], ellagic acid [ 12 ], caffeic acid [ 13 ], ferulic acid [ 14 ], etc. The novelty aspect concerns studying this influence of UVC irradiation on chitosan-based films modified by phenolic acids which may function as chitosan cross-linkers as well as antioxidant agents [ 15 , 16 ]. Chitosan/phenolic acid-based materials may find potential applications in food technology, as encapsulating agents, biomaterials, bioadsorbents or coatings [ 17 , 18 , 19 ].…”

Biomaterials with Potential Use in Bone Tissue Regeneration—Collagen/Chitosan/Silk Fibroin Scaffolds Cross-Linked by EDC/NHS

“…Chitosan can be obtained from food waste, silk fibroin from textile waste, and collagen is a raw material widely available in the animal world. The newest research shows that marine collagen is being used more and more in science [ 4 , 5 , 6 , 7 ]. It can be used in the biomedical, pharmaceutical and cosmetic industries [ 3 , 6 ].…”

“…The newest research shows that marine collagen is being used more and more in science [ 4 , 5 , 6 , 7 ]. It can be used in the biomedical, pharmaceutical and cosmetic industries [ 3 , 6 ]. However, the limitation of this type of collagen is low denaturation temperature, and researchers are constantly working to improve its properties and find the best applications.…”