In situ grafted nanostructured ZnO/carboxymethyl cellulose nanocomposites for efficient delivery of curcumin to cancer

Upadhyaya, Laxmi; Singh, Jay; Agarwal, Vishnu; Pandey, Avinash C.; Verma, Swati; Das, Parimal; Tewari, Ravi Prakash

doi:10.1007/s10965-014-0550-0

Cited by 68 publications

(23 citation statements)

References 30 publications

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“…Polymers or blends having nano-sized fillers exhibits markedly improved mechanical, thermal, and optical properties when compared to pure polymers or their traditional composites. Also, improving the electrical and magnetic properties of the polymeric materials is the subject that attracts many investigators [5][6][7][8][9][10][11][12][13][14][15][16].…”

Section: Introductionmentioning

confidence: 99%

“…CMC has unique properties such as high viscosity, transparency, non-toxic, biocompatibility, and biodegradability. It has been widely used for several applications such as drug delivery, textile printing and paper industry [7,10,20]. Polyvinyl alcohol (PVA) is a semi-crystalline polymer, nontoxic, biocompatible and noncarcinogenic.…”

Section: Introductionmentioning

confidence: 99%

“…These fillers include Sb 2 O 3 [5], hydroxyapatite (HA) [6], zirconium hydroxide [8], Ag [9], and ZnO [10], cellulose nanocrystals (CNC) [28], and nanoclay [29]. Yadava et al [11] prepared graphene oxide (GO, at 1wt.%)/CMC/alginate composite with improved tensile strength and Young's modulus by 40 and 1128 %, respectively.…”

Section: Introductionmentioning

confidence: 99%

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Synthesis and investigation of the electrical and dielectric properties of Co3O4/(CMC+PVA) nanocomposite films

Sayed

El‐Gamal

2015

J Polym Res

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Cobalt oxide (Co 3 O 4 ) nanoparticles (NPs), with average crystallite size<61 nm, were prepared by a sol-gel method. Two allowed direct optical band gaps of 1.445 and 1.915 eV are found for Co 3 O 4 NPs. Sodium carboxymethyl cellulose (Na-CMC)/polyvinyl alcohol (PVA) blend was doped with Co 3 O 4 at different concentrations<1.0 wt.% to study the electrical and dielectric properties of these nanocomposite films. Scanning electron microscopy images revealed a good dispersion of Co 3 O 4 NPs on the surface of the CMC/PVA films. The current-voltage characteristics are of non-ohmic behavior. The dielectric permittivity (ε') was studied in the frequency and temperature range of 5.0 kHz-5.0 MHz and 308-408 K and was found to depend on the Co 3 O 4 content. The dielectric loss (ε^) also increases and shows wave-like behavior with increasing Co 3 O 4 ratio. Increasing Co 3 O 4 NPs content leads to the formation of more number of three-dimensional semiconducting connected networks inside CMC/PVA matrix, leading to increasing both DC and AC conductivities. The correlated barrier hopping (CBH) is the most suitable mechanism to explain the AC conduction behavior in the Co 3 O 4 / Na-CMC/ PVA nanocomposite films.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synthesis and investigation of the electrical and dielectric properties of Co3O4/(CMC+PVA) nanocomposite films

Sayed

El‐Gamal

2015

J Polym Res

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“…The broad peaks at 3434 cm −1 are due to OH‐ stretching of physically adsorbed water on the surface of ZnO (Figure , b). The two strong sharp peaks at 574 cm −1 and 419 cm −1 are due to stretching and torsional vibration modes of ZnO metal oxide bond . The O‐Cmc/ZnO (Figure .c) displays a sharp peak at 420 cm −1 that confirms the existence of ZnO.…”

Section: Resultsmentioning

confidence: 99%

Preparation and In Vitro Biological Evaluation of Lawsone Loaded O‐Carboxymethyl Chitosan/Zinc Oxide Nanocomposite for Wound‐Healing Application

Sakthiguru

Sithique

2020

ChemistrySelect

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A biopolymer based nanocomposite with O‐Carboxymethyl chitosan (O‐Cmc), nano zinc oxide (ZnO) and Lawsone (Ln) with proving advantages in antibacterial wound healing application was prepared. The physiochemical characteristics of the nanocomposite (NCs) was analysed by Fourier Transmission Infrared spectroscopy (FT‐IR), X‐Ray Diffractometer (XRD), Scanning electron Microscopy (SEM), Transmission electron microscope (TEM) and Thermogravimetric analysis (TGA). The biological properties such as anti‐inflammatory, anti‐oxidant activities were investigated in vitro. The nanocomposite also possesses efficient drug encapsulation and releasing profile with greater stability in phosphate buffer saline (PBS) and Dulbecco's minimal essential medium (DMEM). The results of the antibacterial studies show its enhanced bactericidal nature. The results obtained from MTT assay, Ethidium bromide stained fluorescence image and in vitro wound scratch assay show greater cell viability with the closure of scratch wound obviously proves it′s prominent biocompatible, wound closure nature. These biological properties show that the prepared nanocomposite has a greater potential to act as an excellent biomaterial in the field of wound care applications.

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“…It is derived from the rhizome of the East Indian plant curcuma longa and comprises major chemical component of turmeric [24,25]. Curcumin exhibits a wide range of biological and pharmacological properties, including anti-inflammatory, anti-cancer, anticoagulant, antibacterial, and also antioxidant characteristics [26][27][28][29]. One of the main shortcomings of curcumin are water-insolubility and instability which lead to weak bioavailability and makes it inactive in clinical trials [27,30,31].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of curcumin segmented polyurethane with induced antiplatelet activity

et al. 2015

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The main goal of this study is the synthesis of hemocompatible polyurethane elastomer containing curcumin by the reaction of poly(ξ-caprolactone) (PCL), and 1,6-hexamethylene diisocyanate (HDI), which was chain extended with varying molar ratios of 1,4-butandiol (BDO), and curcumin. Molecular structure of the synthesized polyurethane was confirmed using FT-IR and 1 HNMR spectroscopy techniques. The effect of curcumin on characteristics of the synthesized polymers was analyzed by gel permeation chromatography (GPC), differential scanning calorimetry (DSC), tensile testing, and also water contact angle measurement (WCA). The influence of curcumin on antiplatelet behavior of the curcumin extended elastomer was confirmed by static platelet adhesion (SPA) test and the number of the adhered platelets was determined using the lactate dehydrogenase (LDH) assay, in comparison with the polymer extended solely with BDO. Thermal and mechanical properties as well as hydrophobicity are enhanced through increasing curcumin content. Overall, improvement in mentioned properties led to enhanced antiplatelet behavior of curcumin containing segmented PU elastomers (PUcs).

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In situ grafted nanostructured ZnO/carboxymethyl cellulose nanocomposites for efficient delivery of curcumin to cancer

Cited by 68 publications

References 30 publications

Synthesis and investigation of the electrical and dielectric properties of Co3O4/(CMC+PVA) nanocomposite films

Synthesis and investigation of the electrical and dielectric properties of Co3O4/(CMC+PVA) nanocomposite films

Preparation and In Vitro Biological Evaluation of Lawsone Loaded O‐Carboxymethyl Chitosan/Zinc Oxide Nanocomposite for Wound‐Healing Application

Synthesis and characterization of curcumin segmented polyurethane with induced antiplatelet activity

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