2020
DOI: 10.1021/acs.analchem.0c00469
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In Situ Formation of Gold Nanoparticles Decorated Ti3C2 MXenes Nanoprobe for Highly Sensitive Electrogenerated Chemiluminescence Detection of Exosomes and Their Surface Proteins

Abstract: In this work, an ultrasensitive electrogenerated chemiluminescence (ECL) biosensor for exosomes and their surface proteins was developed by the in situ formation of gold nanoparticles (AuNPs) decorated Ti3C2 MXenes hybrid with aptamer modification (AuNPs-MXenes-Apt). In this strategy, the exosomes were efficiently captured on an exosome recognized CD63 aptamer modified electrode interface. Meanwhile, in situ formation of gold nanoparticles on single layer Ti3C2MXenes with aptamer (MXenes-Apt) modification was … Show more

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Cited by 194 publications
(90 citation statements)
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References 46 publications
(52 reference statements)
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“…Many scholars [58] have realized the detection of exosomes by CD63 aptamer with good detection results. Zhang and his colleagues [59] used gold nanoparticle modified by Ti3C2 and CD63 aptamer to construct a hypersensitive electrochemiluminescence sensor for exosomes and their surface proteins. In this strategy, not only exosomes were specifically and efficiently recognized, but also bare catalytic surfaces of gold nanoparticles with high electrocatalytic activity were provided.…”
Section: Methods Of Exosomes Detectionmentioning
confidence: 99%
See 2 more Smart Citations
“…Many scholars [58] have realized the detection of exosomes by CD63 aptamer with good detection results. Zhang and his colleagues [59] used gold nanoparticle modified by Ti3C2 and CD63 aptamer to construct a hypersensitive electrochemiluminescence sensor for exosomes and their surface proteins. In this strategy, not only exosomes were specifically and efficiently recognized, but also bare catalytic surfaces of gold nanoparticles with high electrocatalytic activity were provided.…”
Section: Methods Of Exosomes Detectionmentioning
confidence: 99%
“… The principle of detecting exosomes based on Ti3C2 MXenes biosensor ECL modified by in situ formation of gold nanoparticles [59] …”
Section: Methods Of Exosomes Detectionmentioning
confidence: 99%
See 1 more Smart Citation
“…[98] To date, they have been functionalized with antibodies, DNA, enzymes, and aptamers, to impart features such as enhanced sensitivity or selectivity. [99][100][101][102][103] As Mxenes possess a large surface area, there is potential for immobilization of large amounts of biological molecules.…”
Section: Max Phasesmentioning
confidence: 99%
“…[12] In most ECL sensing platforms, MXene was employed as signal amplifier and catalytical probes to construct the active transducer surfaces. [13] For example, Liu's group combined the multilayer MXene with Nafion membrane to improve the electron transfer capacity of pure Nafion and developed the label-free single-nucleotide mismatch discrimination based on the solid-state ECL platform. [14] Dai et al utilized the MXene as carriers to load the ECL coreactant of black phosphorous quantum dots and luminophore of Ru(dcbpy) 3 2 + to develop the self-enhanced exosomes sensing.…”
Section: Introductionmentioning
confidence: 99%