In-situ fabrication of well-distributed gold nanocubes on thiol graphene as a third-generation biosensor for ultrasensitive glucose detection

Chu, Zhenyu; Liu, Yu; Xu, Ying; Shi, Lei; Peng, Jingmeng; Jin, Wanqin

doi:10.1016/j.electacta.2015.06.123

Cited by 33 publications

(15 citation statements)

References 42 publications

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“…The superior sensing performance of GOx/Au/MXene/Nafion/GCE is attributed to the improvement in the relative activity of GOx in the presence of Au nanoparticles. It has been widely reported that the biosensing properties of graphene-based sensors can be dramatically improved by anchoring Au nanoparticles on the surface of graphene nanosheets5354555657. In a similar way, dispersion of Au nanoparticles on the surface of MXene nanosheets is expected to improve the electrical conductivity and makes the resultant Au/MXene composite as a better electrochemical transducer/enzyme immobilization matrix.…”

Section: Discussionmentioning

confidence: 99%

Novel amperometric glucose biosensor based on MXene nanocomposite

Rakhi

Nayak

Xia

et al. 2016

Sci Rep

302

187

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A biosensor platform based on Au/MXene nanocomposite for sensitive enzymatic glucose detection is reported. The biosensor leverages the unique electrocatalytic properties and synergistic effects between Au nanoparticles and MXene sheets. An amperometric glucose biosensor is fabricated by the immobilization of glucose oxidase (GOx) enzyme on Nafion solubilized Au/ MXene nanocomposite over glassy carbon electrode (GCE). The biomediated Au nanoparticles play a significant role in facilitating the electron exchange between the electroactive center of GOx and the electrode. The GOx/Au/MXene/Nafion/GCE biosensor electrode displayed a linear amperometric response in the glucose concentration range from 0.1 to 18 mM with a relatively high sensitivity of 4.2 μAmM−1 cm−2 and a detection limit of 5.9 μM (S/N = 3). Furthermore, the biosensor exhibited excellent stability, reproducibility and repeatability. Therefore, the Au/MXene nanocomposite reported in this work is a potential candidate as an electrochemical transducer in electrochemical biosensors.

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Section: Discussionmentioning

confidence: 99%

Novel amperometric glucose biosensor based on MXene nanocomposite

Rakhi

Nayak

Xia

et al. 2016

Sci Rep

302

187

View full text Add to dashboard Cite

show abstract

“…Successful biosensors for the determination of glucose were produced using DET-capable FAD-GDH, even for continuous glucose monitoring [78,79]. Moreover, some biosensors for the glucose detection were capable of operating at low potentials (e.g., −0.4 V versus standard hydrogen electrode (SHE)), thus reducing the risk of false biosensor response owing to interference [80]. Lactate biosensors based on DET-capable lactate dehydrogenase were demonstrated as well [81].…”

Section: Development Of Biosensors and Biofuel Cellsmentioning

confidence: 99%

Nanocatalysts Containing Direct Electron Transfer-Capable Oxidoreductases: Recent Advances and Applications

Ratautas

Dagys

2019

Catalysts

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Direct electron transfer (DET)-capable oxidoreductases are enzymes that have the ability to transfer/receive electrons directly to/from solid surfaces or nanomaterials, bypassing the need for an additional electron mediator. More than 100 enzymes are known to be capable of working in DET conditions; however, to this day, DET-capable enzymes have been mainly used in designing biofuel cells and biosensors. The rapid advance in (semi) conductive nanomaterial development provided new possibilities to create enzyme-nanoparticle catalysts utilizing properties of DET-capable enzymes and demonstrating catalytic processes never observed before. Briefly, such nanocatalysts combine several cathodic and anodic catalysis performing oxidoreductases into a single nanoparticle surface. Hereby, to the best of our knowledge, we present the first review concerning such nanocatalytic systems involving DET-capable oxidoreductases. We outlook the contemporary applications of DET-capable enzymes, present a principle of operation of nanocatalysts based on DET-capable oxidoreductases, provide a review of state-of-the-art (nano) catalytic systems that have been demonstrated using DET-capable oxidoreductases, and highlight common strategies and challenges that are usually associated with those type catalytic systems. Finally, we end this paper with the concluding discussion, where we present future perspectives and possible research directions.

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“…Besides carbon, gold and platinum inks are also employed to print working electrodes, being attractive, despite the higher cost, for their catalytic properties, high conductivity, high mechanical strength [ 55 , 67 ] and offering some unique functionalization opportunities (e.g., chemisorption of thiols on Au, widely employed in biosensing). SPEs for detection of antibiotics that are based on working electrodes made of noble metals include pre-treated platinum screen-printed electrodes (SPEs) for the quantification of the strength of garlic, a natural antibiotic [ 68 ], and gold SPEs for the detection of fluoroquinolones [ 40 ], streptomycin [ 41 ], tetracyclines [ 42 ] and cefixime [ 47 ].…”

Section: Screen-printed Electrodesmentioning

confidence: 99%

Detection of Antibiotics and Evaluation of Antibacterial Activity with Screen-Printed Electrodes

Munteanu

Titoiu

Marty

et al. 2018

Sensors

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This review provides a brief overview of the fabrication and properties of screen-printed electrodes and details the different opportunities to apply them for the detection of antibiotics, detection of bacteria and antibiotic susceptibility. Among the alternative approaches to costly chromatographic or ELISA methods for antibiotics detection and to lengthy culture methods for bacteria detection, electrochemical biosensors based on screen-printed electrodes present some distinctive advantages. Chemical and (bio)sensors for the detection of antibiotics and assays coupling detection with screen-printed electrodes with immunomagnetic separation are described. With regards to detection of bacteria, the emphasis is placed on applications targeting viable bacterial cells. While the electrochemical sensors and biosensors face many challenges before replacing standard analysis methods, the potential of screen-printed electrodes is increasingly exploited and more applications are anticipated to advance towards commercial analytical tools.

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In-situ fabrication of well-distributed gold nanocubes on thiol graphene as a third-generation biosensor for ultrasensitive glucose detection

Cited by 33 publications

References 42 publications

Novel amperometric glucose biosensor based on MXene nanocomposite

Novel amperometric glucose biosensor based on MXene nanocomposite

Nanocatalysts Containing Direct Electron Transfer-Capable Oxidoreductases: Recent Advances and Applications

Detection of Antibiotics and Evaluation of Antibacterial Activity with Screen-Printed Electrodes

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