Novel amperometric glucose biosensor based on MXene nanocomposite

Abstract

A biosensor platform based on Au/MXene nanocomposite for sensitive enzymatic glucose detection is reported. The biosensor leverages the unique electrocatalytic properties and synergistic effects between Au nanoparticles and MXene sheets. An amperometric glucose biosensor is fabricated by the immobilization of glucose oxidase (GOx) enzyme on Nafion solubilized Au/ MXene nanocomposite over glassy carbon electrode (GCE). The biomediated Au nanoparticles play a significant role in facilitating the electron exchange between the electroactive center of GOx and the electrode. The GOx/Au/MXene/Nafion/GCE biosensor electrode displayed a linear amperometric response in the glucose concentration range from 0.1 to 18 mM with a relatively high sensitivity of 4.2 μAmM−1 cm−2 and a detection limit of 5.9 μM (S/N = 3). Furthermore, the biosensor exhibited excellent stability, reproducibility and repeatability. Therefore, the Au/MXene nanocomposite reported in this work is a potential candidate as an electrochemical transducer in electrochemical biosensors.

Selective Calixarene‐Directed Synthesis of MXene Plates, Crumpled Sheets, Spheres, and Scrolls

“…1 They have exciting electronic and mechanical properties and this has invigorated further research from the wider community with the aim of exploiting and enhancing their properties for a diverse range of technologies, including energy production and storage, 2,3 bio-sensing 4,5,6 and antibacterial activity. 7 MXenes are composed of early transition metal carbide/nitrides which are produced via etching of the 3D MAX parent phase followed by solution based exfoliation using sonication.…”

Insights into 2D MXenes for Versatile Biomedical Applications: Current Advances and Challenges Ahead

“…In addition, MXene composite‐based biosensor also exhibits high sensitivity, broad sensitive range, and excellent stability. For instance, the Au/MXene nanocomposite platform was developed for the detection of sensitive enzymatic glucose 55. A general trend of increasing current at increased glucose concentration has been observed in the measurement of GO x /Au/MXene/Nafion/GCE biosensors (Figure 9f), which exhibits a linear amperometric response in the glucose concentration range from 0.1 to 18 × 10 −3 m with a relatively high sensitivity of 4.2 µA mM −1 cm −2 and a detection limit of 5.9 × 10 −6 m (Figure 9g).…”

“…To be specific, the derivatives of emerging research of 2D MXenes in nanomedicine could be categorized into therapeutic modality,45, 46, 47, 48, 49, 51, 52 diagnosis imaging,46, 47, 49, 51, 53 biosensing,54, 55, 56, 57 antimicrobial,58, 59 and biosafety evaluation 50. The bigger picture is that by gaining deeper insights into the material science and biological behavior of 2D MXene nanosheets for existing and emerging biomedical modalities, we will be able to facilitate immense and promising applications with clinical‐translation potential in benefitting the human health.…”

MXene‐Based Composites: Synthesis and Applications in Rechargeable Batteries and Supercapacitors

“…As time goes on, nanowire lines are interwoven to cover the surface. [221] In addition to in situ reduction, MXenes can adsorb on metal surfaces to form unique composite materials. For example, a functionalized luminol group was used to modify a Au/Mo 2 C composite, which enabled the application of the composite to an electrochemical luminescence sensor that provides strong electro-chemiluminescence.…”

“…[163,173,175] As an example, the co-catalysts of the Ti 3 C 2 T x /Zn x Cd 1−x S composite have an excellent photocatalytic performance for hydrogen production, since both materials contribute a synergistic effect. Therefore, the MXene-based composites apply in the biosensor, [189,221] and optical/electronic devices. [215] The surfaces of the MXene layers have many active sites, [137,219] which can be influenced by some substances, such as some specific molecules, [203] temperature variation, [203] light, [163] and so on.…”