In Situ Fabrication of Porous Nanostructures Derived from Bimetal-Organic Frameworks for Highly Sensitive Non-Enzymatic Glucose Sensors

Abstract

Metal-organic framework (MOF) based porous derivatives have been attractive materials for high-performance electrochemical sensors due to their high surface-area, stability and activities. Herein, an in situ fabrication method is proposed to obtain porous Cu/Co bimetallic MOF-based derivatives on the flexible carbon cloth for glucose sensing. The process is also developed with three critical steps. Firstly, uniform Cu(OH)2 nanorods are directly formed through wet chemical method on Cu sputtered carbon cloth. Then, oriented growth of Zeolitic Imidazolate Framework-67 (ZIF-67) and ion-exchange convert the sample into Cu-Co-ZIF nanosheets. Finally, porous Cu-Co-ZIF derivatives are obtained by thermal annealing. The fabrication mechanism has been discussed through detailed characterizations of intermediate and final products. The as-obtained nanostructures with rich reaction sites and short ion diffusion path show excellent electrochemical properties for glucose sensing (high sensitivity of 18.68 mA mM-1 cm-2, fast response time of 1.5 s and low detection limit of 2 μM). This study proposes a practical fabrication strategy for bimetallic MOF-based porous nanostructures, which are promising for a wide variety of electrochemical applications.

Artificial enzyme innovations in electrochemical devices: advancing wearable and portable sensing technologies

“…It is pivotal to note that a majority of these groundbreaking MOF-centric sensors have undergone rigorous testing across varied body fluids, notably blood serum, urine, and saliva. 126 In a recent study, Wang et al heralded a significant leap in sweat sensing methodologies. Given the pocket composed by tryptophan (Trp)/histidine (His) and copper sites, natural ascorbate oxidase can selectively captured and identified ascorbate (Fig.…”

“…5C–G), 119 Cu–CAT MOF fractals on carbon paper, 125 and the bimetallic 2D Cu–Co–ZIF derivatives on CC. 126 A standout iteration in this series is the bimetallic 2D Cu–Co–ZIF derivative on a flexible CC electrode. Its superlative sensitivity, eclipsing other MOFs and MOF-derived materials, is credited to its distinct 2D blueprint and the synergetic redox dynamism of Cu and Co ions in alkaline surroundings.…”

“…It is pivotal to note that a majority of these groundbreaking MOF-centric sensors have undergone rigorous testing across varied body fluids, notably blood serum, urine, and saliva. 126…”

Glucose Detection Devices and Methods Based on Metal–Organic Frameworks and Related Materials

“…Some other researchers developed flexible and enzymeless electrochemical detection systems of glucose, based on a variety of MOFs composites, including CuO/NiO/carbon nanocomposites deposited on cello tape, [ 113 ] sandpaper‐supported Cu‐MOF, [ 194 ] Co‐MOF/CC/paper, [ 195 ] ZIF‐67/carbon fibers, [ 196 ] Cu‐catecholate (Cu‐CAT) MOF fractals/carbon paper, [ 197 ] and Cu‐Co‐ZIF derivatives/CC. [ 198 ] The analytical performances of these sensors are summarized in Table 6 , which indicated that the bimetallic 2D Cu‐Co‐ZIF derivative modified flexible CC electrode showed remarkably high sensitivity compared to the reported other pristine MOFs, MOF composites, and MOF‐derived materials, [ 198 ] conceivably due to the enriched reaction sites induced by the 2D structures as well as the synergistic effect of Cu 1+/2+ and Co 2+/3+ redox pairs formed in an alkaline medium for the mediated oxidation of glucose. Most of these flexible MOFs‐based sensors were, however, applied to more common body fluids such as human blood serum, urine, saliva.…”

Controllable Synthesis of Ni/Co-TCPP MOFs with Different Morphologies and Their Application in Electrochemical Detection of Glucose

“…34 Besides, compared with monometallic MOFs, bimetallic MOFs have synergistic effects and strong electronic effects between the two metals, it can improve the sensing performance of MOFs materials. 35,36 Also，it is reported that Ni/ Co bimetallic MOFs have good catalytic properties for glucose in lye. Li and his colleagues report that two-dimensional Ni/Co bimetallic MOFs nanosheets are used in glucose sensors.…”