In Situ Electrospinning Iodine-Based Fibrous Meshes for Antibacterial Wound Dressing

Abstract

For effective application of electrospinning and electrospun fibrous meshes in wound dressing, we have in situ electrospun poly(vinyl pyrrolidone)/iodine (PVP/I), PVP/poly(vinyl pyrrolidone)-iodine (PVPI) complex, and poly(vinyl butyral) (PVB)/PVPI solutions into fibrous membranes by a handheld electrospinning apparatus. The morphologies of the electrospun fibers were examined by SEM, and the hydrophobicity, gas permeability, and antibacterial properties of the as-spun meshes were also investigated. The flexibility and feasibility of in situ electrospinning PVP/I, PVP/PVPI, and PVB/PVPI membranes, as well as the excellent gas permeabilities and antibacterial properties of the as-spun meshes, promised their potential applications in wound healing.Electronic supplementary materialThe online version of this article (10.1186/s11671-018-2733-9) contains supplementary material, which is available to authorized users.

Physical Structure Induced Hydrophobicity Analyzed from Electrospinning and Coating Polyvinyl Butyral Films

“…To ensure the wettability of the prepared PVB films, SWCA were measured and shown in Table 1. One can find that the spin-coating and bar-coating PVB films showed hydrophilicity with SWCA <90 ∘ , while the electrospun films showed hydrophobicity with SWCA>90 ∘ , which agreed with the previous study [7,10,11]. Moreover, the bar-coating PVB films had larger SWCA than spin-coating ones generally.…”

“…From (2), one can find that the smaller is, the more hydrophobicity will be obtained. Specifically to the electrospun PVB films, the smaller the fiber diameter is, the smaller will be achieved, and then higher hydrophobicity will be shown [5,7,10,11]. From lower inset images in Figure 2, we can obviously find that negative electrospun PVB fibers had smaller diameters and less uniform and consequently exhibited higher SWCA.…”

“…The wetting behavior of solid surfaces by a liquid as a very important aspect of surface properties has been a focused interest for a long time [1][2][3][4] and has shown a wide variety of practical applications in various fields, such as protecting clothes [5], medical care [6][7][8], and filtration [9]. Consequently, great efforts have been made to find the way to control the surface wettability [10][11][12][13].…”

“…Moreover, PVB shows both hydrophobic and hydrophilic properties due to its chemical structure with both vinyl butyral group and vinyl hydroxyl group [10,25]. And previous study has suggested that electrospun PVB nanofibrous structures and patterns showed larger water contact angle (WCA) than that of the solution casting film [7,10,11]. However, these works most focus on the electrospun PVB meshes and rarely discuss the comparison of the structures between the different methods.…”

Measurement of Adhesion of In Situ Electrospun Nanofibers on Different Substrates by a Direct Pulling Method

“…anks to the advantages of large surface-area-to-volume ratio of as-spun fibers and high porosity of the fiber meshes, electrospun fibers and meshes have shown potential applications in various fields such as nanosensors [5], filtrations [6][7][8], and wound dressings [9][10][11]. Usually, electrospun fibers and meshes were collected onto substrates, namely, collectors.…”