Recent Advances in Hemostasis at the Nanoscale

Wang, Xiaoxiong; Liu, Qi; Sui, Jin-Xia; Ramakrishna, Seeram; Yu, Miao; Zhou, Yu; Jiang, Xingyu; Long, Yun‐Ze

doi:10.1002/adhm.201900823

Cited by 66 publications

(37 citation statements)

References 167 publications

(65 reference statements)

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“…Blood is the most important fluid connective tissue in the human body. In the human body, blood plays a variety of physiological functions such as gas transportation, material transportation, immune detection and etc., which is an important component to maintain normal operation within the body ( Hoffman et al, 2004 ; Li et al, 2017 ; Makhov and Zakharov, 2018 ; Wang et al, 2019 ). Hemorrhage cause by wars, car accidents and trauma around the world causes mortality of many soldiers and civilians every year ( Eastridge et al, 2012 ; Shlaifer et al, 2017 ).…”

Section: Introductionmentioning

confidence: 99%

Preparation of Super Absorbent and Highly Active Fish Collagen Sponge and its Hemostatic Effect in vivo and in vitro

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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Effective control of acute wound hemorrhage caused by battlefields, car accidents, natural disasters can highly improve patients’ survival rates. Nevertheless, hemostatic materials on present market have various defects and limitations. This study utilizes tilapia to extract macromolecular type I collagen to prepare a new hemostatic sponge for controlling acute wound bleeding. The extracted fish collagen has high purity, uniform molecular size and high hydroxyproline content. The peptide chain structure and natural high-level structure are intactly preserved. The infrared absorption spectrum showcases that it preserves all the characteristic absorption bands of type I collagen. The developed hemostatic sponge has a uniform honeycomb-shaped porous structure and high water absorption capacity. The biological safety test illustrates that the sponge cell has good compatibility and it will not trigger any inflammatory reaction or immune rejection reactions in the body. The sponge cell could be degraded gradually and completely, which has good biocompatibility and degradation performance. The result of in vitro experiments shows that certain groups or structures in fish collagen molecules can combine specific sites on the surface of blood cells and platelets, which can quickly activate platelets and coagulation system to obtain better coagulation function. The result of In vivo experiments further shows that the fish collagen sponge has fast coagulation speed and low bleeding during the hemostasis process of rabbit ear arteries and rat liver wounds, which proves that it has excellent coagulation performance.

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Section: Introductionmentioning

confidence: 99%

Preparation of Super Absorbent and Highly Active Fish Collagen Sponge and its Hemostatic Effect in vivo and in vitro

Wang

et al. 2022

Front. Bioeng. Biotechnol.

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“…Possible complications of using these methods include secondary bleeding, infection, scar formation, and even tissue necrosis. 36 Polymeric hydrogels can be designed as adhesives for Figure 3. Applications of hydrogel adhesion.…”

Section: Applications Of Hydrogel Adhesionmentioning

confidence: 99%

Engineering Hydrogel Adhesion for Biomedical Applications via Chemical Design of the Junction

Bovone

Dudaryeva

Marco‐Dufort

et al. 2021

ACS Biomater. Sci. Eng.

107

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Hydrogel adhesion inherently relies on engineering the contact surface at soft and hydrated interfaces. Upon contact, adhesion normally occurs through the formation of chemical or physical interactions between the disparate surfaces. The ability to form these adhesion junctions is challenging for hydrogels as the interfaces are wet and deformable and often contain low densities of functional groups. In this Review, we link the design of the binding chemistries or adhesion junctions, whether covalent, dynamic covalent, supramolecular, or physical, to the emergent adhesive properties of soft and hydrated interfaces. Wet adhesion is useful for bonding to or between tissues and implants for a range of biomedical applications. We highlight several recent and emerging adhesive hydrogels for use in biomedicine in the context of efficient junction design. The main focus is on engineering hydrogel adhesion through molecular design of the junctions to tailor the adhesion strength, reversibility, stability, and response to environmental stimuli.

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“…Nanohemostatic technology will likely play a significant role in future-generation hemostatic dressings. 50…”

Section: The Future Of Hemostatic Dressingsmentioning

confidence: 99%

Advances in Hemostatic Wound Dressings: Clinical Implications and Insight

Agarwal

Niezgoda

et al. 2022

Adv Skin Wound Care

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Hemorrhagic shock is one of the leading causes of prehospital death in the armed forces. In this state, the body begins to shut down because of blood volume depletion. In both civilian and military trauma, a significant number of hemorrhage deaths occur in the first several hours after injury. Researchers all over the globe are working to develop relatively inexpensive and easy-to-transport products to prevent soldiers from going into hemorrhagic shock. For example, many advances have been made during the last several years toward the development of ideal hemostatic dressings. No current hemostatic agents meet all of the requirements, but the ideal dressing would fulfill many important measures: minimizes or stops blood flow within minutes, contains hemostatic agents to enhance blood clotting, is easy to apply, does not need preapplication preparation, has a reasonably long shelf life, is safe to use, prevents bacterial or viral transmission, is stable at extreme temperatures, and is inexpensive.For this literature review, the authors conducted an extensive search of academic scientific databases for relevant keywords and assessed and summarized the results. This review aimed to identify recent advances in hemostatic wound dressings; summarize the currently available dressings and their supporting literature; and discuss the compositions, mechanisms of action, and clinical relevance of each category of dressing. In addition, case studies and suggestions for future research into hemorrhage control with new hemostatic agents are provided.

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Recent Advances in Hemostasis at the Nanoscale

Cited by 66 publications

References 167 publications

Preparation of Super Absorbent and Highly Active Fish Collagen Sponge and its Hemostatic Effect in vivo and in vitro

Preparation of Super Absorbent and Highly Active Fish Collagen Sponge and its Hemostatic Effect in vivo and in vitro

Engineering Hydrogel Adhesion for Biomedical Applications via Chemical Design of the Junction

Advances in Hemostatic Wound Dressings: Clinical Implications and Insight

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