In Silico Study of The Component of Eleutherine americana MERR. on Human Estrogen Reseptor Alpha as Potential Anti-Breast Cancer

Abstract

Eleutherine americana (Indonesian: "bawang dayak") has been used traditionally to treat breast cancer by Borneo people. Its compounds contains eleutherine, eleutherinone, eleutherol, isoeleutherine, eleutherinol, dihydroeleutherinol, hongconin, and 6,8-dihydroxy-3,4dimethoxy-1-methyl-anthraquinone-2-carboxylic acid methyl ester. Those compounds showed inhibitory activity against HeLa cell line and 7,12-dimethylbenz(a) anthracene (DMBA) induced mice at concentration of 100mg/mL. The present study was aimed to investigate the potential compounds of Eleutherine americana as anti-breast cancer by docking method. The compounds of Eleutherine americana were docked into estrogen receptor alpha (3ERT) by using AutoDock v4.2, and the binding affinity was compared to the natural ligand (4hydroxytamoxifen). The results showed that the natural ligand has binding free energy of-8.7 kcal/mol, and eleutherinol has the highest affinity with binding free energy of-6.43 kcal/mol compared with the other compounds.

Antiosteoporosis Effects of 70% Ethanolic Extract Combination of Dayak Onion Bulbs (Eleutherine bulbosa (Mill.) Urb) and Cowpea (Vigna unguiculata (L.) Walp.) on the Hypoestrogen Rats

“…7 It contains eleutherinol compounds that were in the silico study have been shown to bind to estrogen alpha receptors (RE-α). 8 This extract also contains liquiritigenin compound that has an affinity to bind with estrogen beta receptors selectively and can promote osteoblast differentiation and inhibit of osteoclast differentiation. 9 Cowpea (Vigna unguiculata (L.) Walp.)…”

Dayak Onions ( Eleutherine bulbosa (Mill.) Urb.) Bulbs Extracts Reduces Blood Pressure of Hypoestrogen Model Rats by Controlling Lipids Profile

“…Urb.) which are from Iridacea family, contain eleutherinol compounds which have been reported that it can bind to estrogen receptors in silico study (Amelia et al, 2015). Considering the traditional use of this plant which has also been used to cure breast cancer, hypertension, diabetes mellitus, decreasing cholesterol, and stroke, it is expected that dayak onion bulbs could be alternative herb on the Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia.…”

Dayak Onions (Eleutherine bulbosa (Mill.) Urb.) Bulbs Extracts Reduce the Blood Pressure of Ovariectomized Rats

“…Examples of widely used SERMs are raloxifene and tamoxifen 4 . The ideal SERMs have anti-estrogen activity in the breast and endometrium, and estrogen activity can reduce the risk of osteoporosis and reduce total cholesterol, triglycerides, LDL, increase HDL, and improve cardiovascular function 5 . So it is encouraging to find an alternative treatment that has an ideal estrogenic effect, that is, agonists on estrogen receptors in non-reproductive organs and antagonists of estrogen receptors in the reproductive organs.…”