In ovo feeding of creatine monohydrate increases performances of hatching and development in breeder chicks

Melo, Lucas Duque; Cruz, Frank George Guimarães; Rufino, João Paulo Ferreira; Melo, Ramon Duque; Feijó, Julmar da Costa; Andrade, Pedro Gabriel Carneiro de; Silva, Fernanda Moura Fernandes; Filho, Pedro Alves de Oliveira

doi:10.1080/10495398.2022.2126368

Cited by 4 publications

(1 citation statement)

References 38 publications

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“…Data from de Oliveira et al ( 214 ) suggest only a 10% decrease in hatchability due to inoculation with probiotics. A decrease in hatchability and embryo mortality was also observed by Melo et al ( 217 ). At the same time, there are numerous data indicating no negative in ovo effects on hatchability and mortality ( 115 , 218 – 220 ), decreased embryo mortality ( 218 ), or improved hatchability ( 221 , 222 ).…”

Section: Discussionsupporting

confidence: 73%

Physiological effects of in ovo delivery of bioactive substances in broiler chickens

Kpodo

Proszkowiec‐Weglarz²

2023

Front. Vet. Sci.

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The poultry industry has improved genetics, nutrition, and management practices, resulting in fast-growing chickens; however, disturbances during embryonic development may affect the entire production cycle and cause irreversible losses to broiler chicken producers. The most crucial time in the chicks' development appears to be the perinatal period, which encompasses the last few days of pre-hatch and the first few days of post-hatch. During this critical period, intestinal development occurs rapidly, and the chicks undergo a metabolic and physiological shift from the utilization of egg nutrients to exogenous feed. However, the nutrient reserve of the egg yolk may not be enough to sustain the late stage of embryonic development and provide energy for the hatching process. In addition, modern hatchery practices cause a delay in access to feed immediately post-hatch, and this can potentially affect the intestinal microbiome, health, development, and growth of the chickens. Development of the in ovo technology allowing for the delivery of bioactive substances into chicken embryos during their development represents a way to accommodate the perinatal period, late embryo development, and post-hatch growth. Many bioactive substances have been delivered through the in ovo technology, including carbohydrates, amino acids, hormones, prebiotics, probiotics and synbiotics, antibodies, immunostimulants, minerals, and microorganisms with a variety of physiological effects. In this review, we focused on the physiological effects of the in ovo delivery of these substances, including their effects on embryo development, gastrointestinal tract function and health, nutrient digestion, immune system development and function, bone development, overall growth performance, muscle development and meat quality, gastrointestinal tract microbiota development, heat stress response, pathogens exclusion, and birds metabolism, as well as transcriptome and proteome. We believe that this method is widely underestimated and underused by the poultry industry.

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Section: Discussionsupporting

confidence: 73%

Physiological effects of in ovo delivery of bioactive substances in broiler chickens

Kpodo

Proszkowiec‐Weglarz²

2023

Front. Vet. Sci.

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Effect of in ovo injection of DL-methionine on hatchability, embryo mortality, hatching weight, blood biochemical parameters and gastrointestinal tract development of breeder chicks

Farias

Cruz

Rufino

et al. 2023

Animal Biotechnology

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In-ovo feeding with creatine monohydrate: implications for chicken energy reserves and breast muscle development during the pre-post hatching period

Dayan,

Melkman-Zehavi,

Goldman

et al. 2023

Front. Physiol.

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The most dynamic period throughout the lifespan of broiler chickens is the pre-post-hatching period, entailing profound effects on their energy status, survival rate, body weight, and muscle growth. Given the significance of this pivotal period, we evaluated the effect of in-ovo feeding (IOF) with creatine monohydrate on late-term embryos’ and hatchlings’ energy reserves and post-hatch breast muscle development. The results demonstrate that IOF with creatine elevates the levels of high-energy-value molecules (creatine and glycogen) in the liver, breast muscle and yolk sac tissues 48 h post IOF, on embryonic day 19 (p < 0.03). Despite this evidence, using a novel automated image analysis tool on day 14 post-hatch, we found a significantly higher number of myofibers with lower diameter and area in the IOF creatine group compared to the control and IOF NaCl groups (p < 0.004). Gene expression analysis, at hatch, revealed that IOF creatine group had significantly higher expression levels of myogenin (MYOG) and insulin-like growth factor 1 (IGF1), related to differentiation of myogenic cells (p < 0.01), and lower expression of myogenic differentiation protein 1 (MyoD), related to their proliferation (p < 0.04). These results imply a possible effect of IOF with creatine on breast muscle development through differential expression of genes involved in myogenic proliferation and differentiation. The findings provide valuable insights into the potential of pre-hatch enrichment with creatine in modulating post-hatch muscle growth and development.

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In ovo feeding of creatine monohydrate increases performances of hatching and development in breeder chicks

Cited by 4 publications

References 38 publications

Physiological effects of in ovo delivery of bioactive substances in broiler chickens

Physiological effects of in ovo delivery of bioactive substances in broiler chickens

Effect of in ovo injection of DL-methionine on hatchability, embryo mortality, hatching weight, blood biochemical parameters and gastrointestinal tract development of breeder chicks

In-ovo feeding with creatine monohydrate: implications for chicken energy reserves and breast muscle development during the pre-post hatching period

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