In-line monitoring and interpretation of an indomethacin anti-solvent crystallization process by near-infrared spectroscopy (NIRS)

Lee, Hea-Eun; Lee, Min‐Jeong; Kim, Woo‐Sik; Jeong, Myung-Yung; Cho, Young-Sang; Choi, Guang J.

doi:10.1016/j.ijpharm.2011.08.044

Cited by 21 publications

(8 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous reports suggested that the IM crystal form, showing a peak at 161 • C, was the γ form, and that the IM crystal form showing a peak at 155 • C was the α form [27,28]. The DSC results were also consistent with the results of the XRPD spectrum and the morphological features [29]. Previous reports suggested that the IM crystal form, showing a peak at 161°C, was the γ form, and that the IM crystal form showing a peak at 155°C was the α form [27,28].…”

Section: Characterization Of Microparticlessupporting

confidence: 87%

“…Previous reports suggested that the IM crystal form, showing a peak at 161°C, was the γ form, and that the IM crystal form showing a peak at 155°C was the α form [27,28]. The DSC results were also consistent with the results of the XRPD spectrum and the morphological features [29]. From the SEM images of IM-NK(50), IM-KP(50), IM-NK(Dry), and IM-KP(Dry) (Figure 4c-f), it was assumed that the IM crystals as IM microparticles without PVA were coated and bound by PVA.…”

Section: Characterization Of Microparticlessupporting

confidence: 87%

See 1 more Smart Citation

Formulation Development of Mucoadhesive Microparticle-Laden Gels for Oral Mucositis: An In Vitro and In Vivo Study

et al. 2020

View full text Add to dashboard Cite

In order to relieve pain due to oral mucositis, we attempted to develop mucoadhesive microparticles containing indomethacin (IM) and gel preparations with IM microparticles that can be applied to the oral cavity. The mucoadhesive microparticles were prepared with a simple composition consisting of IM and polyvinyl alcohol (PVA). Two kinds of PVA with different block properties were used, and microparticles were prepared by heating-filtration and mixing-drying. From the X-ray powder diffraction patterns, differential scanning calorimetry thermograms, and morphological features of the IM microparticles, IM should exist as polymorphic forms in the microparticles. Rapid drug release properties were observed in the IM microparticles. Increased drug retention was observed in IM microparticles containing PVA, and the IM-NK(50) gel, using a common block character PVA and heating-filtration, showed good long-term drug retention properties. In vivo experiments showing significantly higher drug concentrations in the oral mucosa were observed with IM microparticles prepared by heating-filtration, and the IM-NK(50) gel maintained significantly higher drug concentrations in the oral mucosa. From these results, the IM-NK(50) gel may be useful as a preparation for relieving oral mucositis pain.

show abstract

Section: Characterization Of Microparticlessupporting

confidence: 87%

Section: Characterization Of Microparticlessupporting

confidence: 87%

Formulation Development of Mucoadhesive Microparticle-Laden Gels for Oral Mucositis: An In Vitro and In Vivo Study

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Its amorphous form can be conveniently achieved via melting crystallization or crystallization in the presence of an inhibitor (Figure ). − For instance, its amorphous form was obtainable in the presence of a comparable amount of a nonionic polymeric additive, poly(vinylpyrrolidone) (PVP; Figure ), via a solvent evaporation procedure . As expected, increasing the INN/polymer ratio could switch the amorphous INN to crystallize guided by the polymeric additive used, where the polymer-controlled crystallization ensures the appearance of amorphous precursors and elongates their lifetime for the time-resolved detection.…”

Section: Introductionmentioning

confidence: 79%

Direct Growth of Microspheres on Amorphous Precursor Domains in Polymer-Controlled Crystallization of Indomethacin

Huang

Jiang

Yang

et al. 2016

Crystal Growth & Design

View full text Add to dashboard Cite

Polymer-controlled crystallization is becoming an increasingly important approach to achieve functional materials precipitated from the solution phase. Nevertheless, there exist multiple pathways under the control of yet unpredictable kinetic factors, which significantly hinder the mechanistic understanding. Herein, the mechanistic study of polymer-controlled precipitation of a typical drug compound, indomethacin, was performed. The presence of a nonionic additive poly(vinylpyrrolidone) induces the heterogeneous nucleation of networks of dumbbell-shaped crystalline microspheres on amorphous precursor domains, which is an emerging pathway in polymer-controlled crystallization. This pathway is also verified in the precipitation of l-histidine in the presence of poly(acrylic acid) in the current study. As a comparison, the presence of a cationic polymeric additive, branched polyethylenimine, promotes the formation of aggregates of amorphous nanoparticles and the subsequent crystallization of a spherical-shaped microsphere on each aggregate, a pathway in line with those in numerous studies of polymer-controlled crystallization of inorganic compounds. Our results suggest that the heterogeneous crystallization of microspheres on the amorphous precursor domains could be a specific pathway occurring in polymer-controlled precipitation of organic compounds mainly due to the fast kinetics of the precipitation process. In short, our study broadens our understanding of polymer-controlled crystallization of functional organic crystals.

show abstract

“…Lee monitored the antisolvent crystallisation process of indomethacin (IMC) by mixing two liquids (IMC-acetone solution and antisolvent water) in two different orders by instantaneously adding the whole IMC-acetone solution into water (H 2 O/IMC solution system) and by rapidly adding water into the IMC-acetone solution (IMC solution/H 2 O system), employing in-line NIR spectroscopy [32]. Accordingly, the metastable a-form with high purity was produced under the H 2 O/IMC solution system, whereas a powder mixture of the stable c-form and the metastable a-form was obtained in the IMC solution/H 2 O system.…”

Section: Glycine Polymorphism By the Rapid Addition Of Methanol Or Samentioning

confidence: 99%

Change in glycine polymorphs induced by minute-bubble injection during antisolvent crystallisation

Matsumoto

Wada

Onoe

2015

Advanced Powder Technology

View full text Add to dashboard Cite

In-line monitoring and interpretation of an indomethacin anti-solvent crystallization process by near-infrared spectroscopy (NIRS)

Cited by 21 publications

References 19 publications

Formulation Development of Mucoadhesive Microparticle-Laden Gels for Oral Mucositis: An In Vitro and In Vivo Study

Formulation Development of Mucoadhesive Microparticle-Laden Gels for Oral Mucositis: An In Vitro and In Vivo Study

Direct Growth of Microspheres on Amorphous Precursor Domains in Polymer-Controlled Crystallization of Indomethacin

Change in glycine polymorphs induced by minute-bubble injection during antisolvent crystallisation

Contact Info

Product

Resources

About