Imunologia da Leishmaniose tegumentar

Barral‐Netto, Manoel; Badaró, Roberto; Barral, Aldina; Carvalho, Edgar M.

doi:10.1590/s0037-86821986000300010

Cited by 8 publications

(4 citation statements)

References 103 publications

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“…(McMahon-Pratt et al 1986; Grimaldi et al 1987, 1991; Shaw and Lainson 1987, 1989; Barral-Neto et al 1986; Barral 1988) and have demonstrated high and consistent specificity in the characterization of species of this parasite, unequivocally proving its identification (Grimaldi and Tesh 1993; Grimaldi and McMahon-Pratt 1996; Romero et al 2002a, b, 2005; Abbas and Lichtman 2005). …”

Section: Introductionmentioning

confidence: 97%

Characterization of Leishmania spp. causing cutaneous leishmaniasis in Manaus, Amazonas, Brazil

et al. 2010

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In the State of Amazonas, American tegumentary leishmaniasis is endemic and presents a wide spectrum of clinical variability due to the large diversity of circulating species in the region. Isolates from patients in Manaus and its metropolitan region were characterized using monoclonal antibodies and isoenzymes belonging to four species of the parasite: Leishmania (Viannia) guyanensis, 73% (153/209); Leishmania (Viannia) braziliensis, 14% (30/209); Leishmania (Leishmania) amazonensis, 8% (17/209); and Leishmania (Viannia) naiffii, 4% (9/209). The most prevalent species was L. (V.) guyanensis. The principal finding of this study was the important quantity of infections involving more than one parasite species, representing 14% (29/209) of the total. The findings obtained in this work regarding the parasite are further highlighted by the fact that these isolates were obtained from clinical samples collected from single lesions.

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Section: Introductionmentioning

confidence: 97%

Characterization of Leishmania spp. causing cutaneous leishmaniasis in Manaus, Amazonas, Brazil

et al. 2010

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“…En Brasil, el tratamiento de primera línea son los antimoniales pentavalentes por vía endovenosa, debido a que por vía intramuscular es muy doloroso. La vía intralesional es muy común sobre todo en las formas nodulares y las formas ulcerativas únicas o múltiples siempre y cuando el paciente no tenga más de cuatro lesiones y no exista evidencia de celulitis o linfangitis y de segunda línea la Anfotericina B en caso de falla terapéutica a 2 series completas y dosis adecuada de tratamiento con antimoniales pentavalentes en los casos de lesión mucosa leve a moderada y de inicio en los casos de lesión mucosa severa [28].…”

Section: Discussionunclassified

Leishmaniasis cutánea, a propósito de un caso.

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2019

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La Leishmaniasis es una enfermedad parasitaria catalogada como emergente y sin control debido al cambio en el perfil epidemiológico por el surgimiento de nuevos focos y urbanización del ciclo de transmisión. Se describe el caso de un adolescente de la Comunidad Dos Ríos, del Cantón Taisha, quien presentó varias lesiones ulceradas, confirmándose diagnóstico de Leishmaniasis Cutánea mediante estudio histológico, iniciándose tratamiento con sales de antimonio pentavalentes, logrando una resolución progresiva y paulatina de las lesiones. Destacándose la importancia del diagnóstico temprano, tratamiento supervisado, y seguimiento para prevenir complicaciones. Palabras clave: leishmaniasis cutánea, enfermedades cutáneas parasitarias/complicaciones, población rural, adolescente, gluconato de sodio antimonio.

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“…Ansari et al ( 24 ) suggested that despite high IFNγ levels during L. donovani infection, the host fails to control the disease due to an incomplete response to IFNγ. Similarly, high titers of TNF have been observed in sera from patients with active VL and diffuse CL, characterized by high parasite loads ( 25 ). The biological network acting for equilibrium between parasite clearance and tissue preservation in humans involves substantial participation from effector T cells other than Th1 and Th2 ( 26 ).…”

Section: Introductionmentioning

confidence: 91%

“…However, in the case of CL and ML, the immune response itself contributes to lesion progress. In both these forms, patients develop intense inflammatory responses that damage tissues, despite the low number of parasites in lesions ( 25 ), so the disease is mostly associated with a failure of anti-inflammatory cytokine secretion, especially IL-10 ( 77 ). IFNγ and IL-17 levels are substantially elevated in mice lacking the capacity to respond to IL-10.…”

Section: Th17 Cells and Il-17mentioning

confidence: 99%

The Equivocal Role of Th17 Cells and Neutrophils on Immunopathogenesis of Leishmaniasis

Gonçalves-de-Albuquerque

et al. 2017

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Advances in the understanding of leishmaniasis progression indicate that cellular interactions more complex than the Th1/Th2 paradigm define the course of infection. Th17 cells are a crucial modulator of adaptive immunity against Leishmania parasites acting mainly on neutrophil recruitment and playing a dual role at the site of infection. This review describes the roles of both these cell types in linking innate defense responses to the establishment of specific immunity. We focus on the Th17–neutrophil interaction as a crucial component of anti-Leishmania immunity, and the clinical evolution of cutaneous or visceral leishmaniasis. To date, information obtained through experimental models and patient evaluations suggests that the influence of the presence of interleukin (IL)-17 (the main cytokine produced by Th17 cells) and neutrophils during Leishmania infections is strictly dependent on the tissue (skin or liver/spleen) and parasite species. Also, the time at which neutrophils are recruited, and the persistence of IL-17 in the infection microenvironment, may also be significant. A clearer understanding of these interactions will enable better measurement of the influence of IL-17 and its regulators, and contribute to the identification of disease/resistance biomarkers.

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Imunologia da Leishmaniose tegumentar

Cited by 8 publications

References 103 publications

Characterization of Leishmania spp. causing cutaneous leishmaniasis in Manaus, Amazonas, Brazil

Characterization of Leishmania spp. causing cutaneous leishmaniasis in Manaus, Amazonas, Brazil

Leishmaniasis cutánea, a propósito de un caso.

The Equivocal Role of Th17 Cells and Neutrophils on Immunopathogenesis of Leishmaniasis

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