1986
DOI: 10.1590/s0037-86821986000300010
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Imunologia da Leishmaniose tegumentar

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Cited by 8 publications
(4 citation statements)
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“…(McMahon-Pratt et al 1986; Grimaldi et al 1987, 1991; Shaw and Lainson 1987, 1989; Barral-Neto et al 1986; Barral 1988) and have demonstrated high and consistent specificity in the characterization of species of this parasite, unequivocally proving its identification (Grimaldi and Tesh 1993; Grimaldi and McMahon-Pratt 1996; Romero et al 2002a, b, 2005; Abbas and Lichtman 2005). …”
Section: Introductionmentioning
confidence: 97%
“…(McMahon-Pratt et al 1986; Grimaldi et al 1987, 1991; Shaw and Lainson 1987, 1989; Barral-Neto et al 1986; Barral 1988) and have demonstrated high and consistent specificity in the characterization of species of this parasite, unequivocally proving its identification (Grimaldi and Tesh 1993; Grimaldi and McMahon-Pratt 1996; Romero et al 2002a, b, 2005; Abbas and Lichtman 2005). …”
Section: Introductionmentioning
confidence: 97%
“…En Brasil, el tratamiento de primera línea son los antimoniales pentavalentes por vía endovenosa, debido a que por vía intramuscular es muy doloroso. La vía intralesional es muy común sobre todo en las formas nodulares y las formas ulcerativas únicas o múltiples siempre y cuando el paciente no tenga más de cuatro lesiones y no exista evidencia de celulitis o linfangitis y de segunda línea la Anfotericina B en caso de falla terapéutica a 2 series completas y dosis adecuada de tratamiento con antimoniales pentavalentes en los casos de lesión mucosa leve a moderada y de inicio en los casos de lesión mucosa severa [28].…”
Section: Discussionunclassified
“…Ansari et al ( 24 ) suggested that despite high IFNγ levels during L. donovani infection, the host fails to control the disease due to an incomplete response to IFNγ. Similarly, high titers of TNF have been observed in sera from patients with active VL and diffuse CL, characterized by high parasite loads ( 25 ). The biological network acting for equilibrium between parasite clearance and tissue preservation in humans involves substantial participation from effector T cells other than Th1 and Th2 ( 26 ).…”
Section: Introductionmentioning
confidence: 91%
“…However, in the case of CL and ML, the immune response itself contributes to lesion progress. In both these forms, patients develop intense inflammatory responses that damage tissues, despite the low number of parasites in lesions ( 25 ), so the disease is mostly associated with a failure of anti-inflammatory cytokine secretion, especially IL-10 ( 77 ). IFNγ and IL-17 levels are substantially elevated in mice lacking the capacity to respond to IL-10.…”
Section: Th17 Cells and Il-17mentioning
confidence: 99%