Imunoglobulinas G do liquido cefalorraqueano em afecções do sistema nervoso

Abstract

Cerebrospinal fluid IGG and the relations with total protein, and with prealbumin + albumin and the IGG index were studied in 160 patients with various neurological disorders. These patients were distributed in 8 groups according to diagnosis as follows: inflammatory (21 cases); demyelinating (31 cases); degenerative (10 cases); cerebrovascular (19 cases); tumoral (3 cases); convulsive (20 cases); headache (11 cases); other neurological disorders (45 cases). According to the results (table 1) the best applicability of IGG study is the group of chronic inflammatory diseases (neurosyphilis and neurocysticercosis) and the demyelinating disorders (multiple sclerosis). Emphasis is given to the possibility of the occurrence of local synthesis of IGG in the central nervous system in these 2 groups.

Roberto Melaragno's scientific contributions to Brazilian Neurology

“…Melaragno published several scientific articles in Brazil, mainly in Arquivos de Neuro-Psiquiatria (the official journal of the Brazilian Academy of Neurology), and abroad, particularly in France 9,10,11,12,13,14,15 . Initially, he published on general neurology, then made more frequent contributions in the areas of cerebrovascular diseases and, later, neuroimmunology and multiple sclerosis, including books on these topics 7,8,15 . Notable articles addressed cerebrovascular diseases, studies on the pharmacology of cerebral circulation, thrombosis of the internal carotid artery, intracranial aneurysms, and clinical hemorheology in the study of cerebral blood flow 12,14 .…”

“…Notable articles addressed cerebrovascular diseases, studies on the pharmacology of cerebral circulation, thrombosis of the internal carotid artery, intracranial aneurysms, and clinical hemorheology in the study of cerebral blood flow 12,14 . In neuroimmunology he published articles on cerebrospinal fluid immunoglobulins G in nervous system diseases 15 , and on the topic of neuromuscular diseases, he addressed ocular myopathy, periodic paralysis, and Charcot-Marie disease 10 . In the area of movement disorders, he published articles on cerebellar ataxias, with one of the first descriptions of Pierre-Marie heredo-ataxia or spinocerebellar degeneration (today known as spinocerebellar ataxia or SCAS) in Brazil 9 (Figure 2).…”