2013
DOI: 10.1590/s1679-45082013000400009 View full text |Buy / Rent full text
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Abstract: Objective:To analyze the immunoexpression of the COX-2, p53, and caspase-3 proteins in colorectal adenomas and non-neoplastic mucosa.Methods:72 individuals were subjected to colonoscopy, which provided 50 samples of adenomas and 45 samples of non-neoplastic colorectal mucosa. The tissue samples were obtained via the tissue microarray technique and subjected to immunohistochemical analysis using primary anti-p53, anti-COX-2, and anti-caspase-3 antibodies. The positivity and intensity of the immunoreaction were … Show more

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“… 23 In contrast, a group of scientists from Brazil, in a study using TmA and IHC on positivity and intensity of COX-2 did not find any significant differences between the adenomas and the non-neoplastic colorectal mucosa. 24 Our findings in the present study are however in concordance with most of the recent works regarding its over-expression and its significance as precancerous marker in the colorectal adenoma-carcinoma sequence.…”
Section: Discussionsupporting
“… 6 , 7 Genes upregulated in adenoma relative to normal tissue, which maintained increased expression in colorectal carcinoma and adenoma, would encode proteins suitable as putative targets for immunoprevention. 4 , 5 , 8 The identification of early and easily detectable tumor markers that might contribute to the knowledge of colorectal carcinogenesis and the biological mechanisms required for preinvasive adenoma to progress to carcinoma, are highly relevant subjects. 4 , 5 The process of proliferation and tumor invasion depends, among other factors, on changes in the extracellular matrix (ECM) represented by the loss of cell-cell interaction, ECM degradation by tumor cells through activation of enzymes associated with neoplastic invasion that disorganize and fragment the stromal elements and their own ECM, and the synthesis of ECM components by metastatic tumor cells.…”
Section: Introductionmentioning