Impulse response method for characterization of echogenic liposomes

Raymond, Jason L.; Luan, Ying; Rooij, Tom van; Kooiman, Klazina; Huang, Shihai; McPherson, David D.; Versluis, Michel; Jong, Nico de; Holland, Christy K.

doi:10.1121/1.4916277

Cited by 11 publications

(9 citation statements)

References 48 publications

(91 reference statements)

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“…The size range of ELIP observed to fragment in this study corresponded to the expected resonance size for ELIP at 6 MHz (see Fig. 5 in Raymond et al 2015). ELIP suspensions are known to contain particles as small as tens of nanometers (Kopechek et al 2011).…”

Section: Discussionsupporting

confidence: 77%

Loss of gas from echogenic liposomes exposed to pulsed ultrasound

Raymond

Luan²,

Peng

et al. 2016

Phys. Med. Biol.

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The destruction of echogenic liposomes (ELIP) in response to pulsed ultrasound excitations has been studied acoustically previously. However, the mechanism underlying the loss of echogenicity due to cavitation of ELIP has not been fully clarified. In this study, an ultra-high speed imaging approach was employed to observe the destruction phenomena of single ELIP exposed to ultrasound bursts at a center frequency of 6- MHz. We observed a rapid size reduction during the ultrasound excitation in 139 out of 397 (35 %) ultra-high-speed recordings. The shell dilation rate, which is defined as the microbubble wall velocity divided by the instantaneous radius, Ṙ/R, was extracted from the radius versus time response of each ELIP, and was found to be correlated with the deflation. Fragmentation and surface mode vibrations were also observed and are shown to depend on the applied acoustic pressure and initial radius. Results from this study can be utilized to optimize the theranostic application of ELIP, e.g., by tuning the size distribution or the excitation frequency.

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Section: Discussionsupporting

confidence: 77%

Loss of gas from echogenic liposomes exposed to pulsed ultrasound

Raymond

Luan²,

Peng

et al. 2016

Phys. Med. Biol.

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“…First, bubbles can be loaded with functional nanoparticles as a method to enhance drug delivery. Such self-assembled systems include: microbubbles that are conjugated with liposomes (Kheirolomoom et al 2007;Lentacker et al 2010;Luan et al 2012;Peyman et al 2012;Yan et al 2013), echogenic liposomes (Paul et al 2012;Raymond et al 2015), colloids (Poulichet and Garbin 2015;Huerre et al 2018) and polymeric nanoparticles (Borden and Rege 2012;Burke et al 2012;Mørch et al 2015;Z. Chen et al 2019;Jamburidze et al 2019) (Fig.…”

Section: Models For Novel Agentsmentioning

confidence: 99%

Ultrasound Contrast Agent Modeling: A Review

Versluis

Stride

Lajoinie

et al. 2020

Ultrasound in Medicine & Biology

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153

110

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Ultrasound is extensively used in medical imaging, being safe and inexpensive and operating in real time. Its scope of applications has been widely broadened by the use of ultrasound contrast agents (UCAs) in the form of microscopic bubbles coated by a biocompatible shell. Their increased use has motivated a large amount of research to understand and characterize their physical properties as well as their interaction with the ultrasound field and their surrounding environment. Here we review the theoretical models that have been proposed to study and predict the behavior of UCAs. We begin with a brief introduction on the development of UCAs. We then present the basics of free-gas-bubble dynamics upon which UCA modeling is based. We review extensively the linear and non-linear models for shell elasticity and viscosity and present models for non-spherical and asymmetric bubble oscillations, especially in the presence of surrounding walls or tissue. Then, higher-order effects such as microstreaming, shedding and acoustic radiation forces are considered. We conclude this review with promising directions for the modeling and development of novel agents.

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“…At higher pressures (hundreds of kilopascals), the violent vibrations of microbubbles tend to disrupt the shell and are accompanied by shedding of lipid shell materials [35], [50]- [54]. Similar optical studies have also been made of other varieties of contrast agents, e.g., nanodroplets and echogenic liposomes (ELIP) [55], [56].…”

Section: B Optical Characterization Techniquesmentioning

confidence: 81%

Characterization of Contrast Agent Microbubbles for Ultrasound Imaging and Therapy Research

Mulvana

Browning

Luan

et al. 2017

IEEE Trans. Ultrason., Ferroelect., Freq. Contr.

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The high efficiency with which gas microbubbles can scatter ultrasound compared with the surrounding blood pool or tissues has led to their widespread employment as contrast agents in ultrasound imaging. In recent years, their applications have been extended to include super-resolution imaging and the stimulation of localized bio-effects for therapy. The growing exploitation of contrast agents in ultrasound and in particular these recent developments have amplified the need to characterize and fully understand microbubble behavior. The aim in doing so is to more fully exploit their utility for both diagnostic imaging and potential future therapeutic applications. This paper presents the key characteristics of microbubbles that determine their efficacy in diagnostic and therapeutic applications and the corresponding techniques for their measurement. In each case, we have presented information regarding the methods available and their respective strengths and limitations, with the aim of presenting information relevant to the selection of appropriate characterization methods. First, we examine methods for determining the physical properties of microbubble suspensions and then techniques for acoustic characterization of both suspensions and single microbubbles. The next section covers characterization of microbubbles as therapeutic agents, including as drug carriers for which detailed understanding of their surface characteristics and drug loading capacity is required. Finally, we discuss the attempts that have been made to allow comparison across the methods employed by various groups to characterize and describe their microbubble suspensions and promote wider discussion and comparison of microbubble behavior.

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Impulse response method for characterization of echogenic liposomes

Cited by 11 publications

References 48 publications

Loss of gas from echogenic liposomes exposed to pulsed ultrasound

Loss of gas from echogenic liposomes exposed to pulsed ultrasound

Ultrasound Contrast Agent Modeling: A Review

Characterization of Contrast Agent Microbubbles for Ultrasound Imaging and Therapy Research

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