Loss of gas from echogenic liposomes exposed to pulsed ultrasound

Raymond, Jason L.; Luan, Ying; Peng, Tao; Huang, Shaoling; McPherson, David D.; Versluis, Michel; Jong, Nico de; Holland, Christy K.

doi:10.1088/0031-9155/61/23/8321

Cited by 10 publications

(9 citation statements)

References 65 publications

(151 reference statements)

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“…Such instabilities are often observed for UCAs (see a typical example in Fig. 8a; Raymond et al 2016), especially when using long driving pulses (e.g., for therapeutic applications).…”

Section: Bubble Non-sphericity and Asymmetrymentioning

confidence: 90%

Ultrasound Contrast Agent Modeling: A Review

Versluis

Stride

Lajoinie

et al. 2020

Ultrasound in Medicine & Biology

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153

110

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Ultrasound is extensively used in medical imaging, being safe and inexpensive and operating in real time. Its scope of applications has been widely broadened by the use of ultrasound contrast agents (UCAs) in the form of microscopic bubbles coated by a biocompatible shell. Their increased use has motivated a large amount of research to understand and characterize their physical properties as well as their interaction with the ultrasound field and their surrounding environment. Here we review the theoretical models that have been proposed to study and predict the behavior of UCAs. We begin with a brief introduction on the development of UCAs. We then present the basics of free-gas-bubble dynamics upon which UCA modeling is based. We review extensively the linear and non-linear models for shell elasticity and viscosity and present models for non-spherical and asymmetric bubble oscillations, especially in the presence of surrounding walls or tissue. Then, higher-order effects such as microstreaming, shedding and acoustic radiation forces are considered. We conclude this review with promising directions for the modeling and development of novel agents.

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“…Such instabilities are often observed for UCAs (see a typical example in Fig. 8a; Raymond et al 2016), especially when using long driving pulses (e.g., for therapeutic applications).…”

Section: Bubble Non-sphericity and Asymmetrymentioning

confidence: 90%

Ultrasound Contrast Agent Modeling: A Review

Versluis

Stride

Lajoinie

et al. 2020

Ultrasound in Medicine & Biology

Self Cite

153

110

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“…As vaporized nanodroplets moved away from the ROI as illustrated in Figure 5, there was a significant decrease in the acoustic signal. The populations of newly vaporized nanodroplets underwent some dynamic processes such as gas diffusion in/out of the microbubbles and the coalescence of microbubbles within the first 100ms (Lajoinie, et al 2014, Raymond, et al 2016. Moreover, the formation of the vortex due to the high MI activation pulse could also push the generated microbubbles out of the imaging plane as there was no confinement in the elevational direction in the Opticell chamber (Raymond, et al 2016).…”

Section: Acoustic Response Immediately After Activationmentioning

confidence: 99%

Quantification of Vaporised Targeted Nanodroplets Using High-Frame-Rate Ultrasound and Optics

Zhang

Lin

Leow

et al. 2019

Ultrasound in Medicine & Biology

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Molecular targeted nanodroplets, promising to extravasate beyond the vascular space, have great potential to improve tumor detection and characterization. High frame rate ultrasound, on the other hand, is an emerging tool for imaging at a frame rate 1-2 orders of magnitude higher than common existing ultrasound operating systems. In this study, we used high frame rate ultrasound combined with optics to study the acoustic response and size distribution of Folate Receptor (FR) -targeted versus Non-Targeted (NT)-nanodroplets in vitro with MDA-MB-231 breast cancer cells immediately after ultrasound activation. A flow velocity mapping technique, Stokes' theory, and optical microscopy were used to estimate the size of both floating and attached vaporized nanodroplets immediately after activation. It was found that the size of floating vaporized nanodroplets was on average more than 7 times larger than the size of vaporized nanodroplets attached to the cells. The results also showed that the acoustic signal of vaporized FR-nanodroplets was persistent after activation, with 70% of the acoustic signals still present 1 second after activation, compared to the vaporized NT-nanodroplets where only 40% of the acoustic signal remains. The optical microscopic images showed on average 6 times more vaporized FR-nanodroplets generated with a wider range of diameters (from 4 to 68 µm) that still attach to the cells compared to vaporized NTnanodroplets (from 1 to 7 µm) with non-specific binding after activation. It was also found that the mean size of attached vaporized FR-nanodroplets was on average about 3-fold larger than that of attached vaporized NT-nanodroplets. The study offers an improved understanding of the vaporization of the targeted nanodroplets in terms of their sizes and acoustic response in comparison with non-targeted ones, taking advantage of high-frame-rate contrast-enhanced ultrasound and optical microscopy. Such understanding would help design optimized methodology for imaging and therapeutic applications.

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“…Plane wave B-mode transmits and receives with all element in parallel, shortening the imaging sequence to less than 1 ms. The frame rates for plane wave B-mode imaging cannot track volumetric oscillations of individual bubbles at frequencies utilized for therapeutic ultrasound (Khokhlova et al 2011, Maxwell et al 2011b, Raymond et al 2016, but is sufficient to assess the dynamics of the bubble cloud as a whole. In addition to monitoring the presence of bubbles, imaging pulses can also be used to instantiate particular bubble behaviors (Radhakrishnan et al 2013).…”

Section: Introductionmentioning

confidence: 99%

Observation and modulation of the dissolution of histotripsy-induced bubble clouds with high-frame rate plane wave imaging

Bader¹,

Hendley²,

Anthony³

et al. 2019

Phys. Med. Biol.

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Focused ultrasound therapies are a noninvasive means to ablate tissue. Histotripsy utilizes short ultrasound pulses with sufficient tension to nucleate bubble clouds that impart lethal strain to the surrounding tissues. Tracking bubble cloud dissolution between the application of histotripsy pulses is critical to ensure treatment efficacy. In this study, plane wave B-mode imaging was employed to monitor bubble cloud motion and grayscale at frame rates up to 11.25 kHz. Minimal changes in the area or position of the bubble clouds were observed 50 ms post excitation. The bubble cloud grayscale was observed to decrease with the square root of time, indicating a diffusion-driven process. These results were qualitatively consistent with an analytic model of gas diffusion during the histotripsy process. Finally, the rate of bubble cloud dissolution was found to be dependent on the output of the imaging pulse, indicating an interaction between the bubble cloud and imaging parameters. Overall, these results highlight the utility of plane wave B-mode imaging for monitoring histotripsy bubble clouds.

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Loss of gas from echogenic liposomes exposed to pulsed ultrasound

Cited by 10 publications

References 65 publications

Ultrasound Contrast Agent Modeling: A Review

Ultrasound Contrast Agent Modeling: A Review

Quantification of Vaporised Targeted Nanodroplets Using High-Frame-Rate Ultrasound and Optics

Observation and modulation of the dissolution of histotripsy-induced bubble clouds with high-frame rate plane wave imaging

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