Improving the osteointegration of Ti6Al4V by zeolite MFI coating

Li, Yong; Jiao, Yilai; Li, Xiaokang; Guo, Zheng

doi:10.1016/j.bbrc.2015.02.157

Cited by 27 publications

(20 citation statements)

References 29 publications

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“…Zeolite MFI coating described that it was biocompatible [24] and osteoconductive [25]. Moreover, the MFI coating on Ti6Al4V scaffolds significantly improved osteointegration and encouraged bone regeneration after implantation [59].…”

Section: Drug-delivering Biomaterialsmentioning

confidence: 94%

Zeolite-based biomaterials for biomedical application: A review

Purnomo

Setyarini

Sulistyaningsih

2018

AIP Conference Proceedings

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Abstract. This review focuses on the latest reports of the use of zeolites, natural as well as synthetic, as biomedical materials. Discussion on biocompatibility, non-toxicity, zeolite for drug delivery materials, zeolite for bone implants and implant coatings, and the mechanical properties of polymer-zeolite composites are included. The section on the interaction between body tissues and zeolite-based biomaterials focuses on their biocompatibility, non-toxicity, and bioactivity. The next section concerns drug delivering biomaterials. Including delivery of a controlled drug, ionic removal, and synthesized drug delivering materials. The final section concern bone graft substitutes and implant-coating to improve corrosion resistance and osteointegration. The implant material system discussed in a further section is an investigation of the mechanical properties of high-density polyethylene(HDPE)-zeolite composites developed as skull bone implant materials.

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Section: Drug-delivering Biomaterialsmentioning

confidence: 94%

Zeolite-based biomaterials for biomedical application: A review

Purnomo

Setyarini

Sulistyaningsih

2018

AIP Conference Proceedings

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“…The nanoparticles loaded on scaffolds as bioactive molecules could enhance the cell adhesion, cell function, cell interaction and biomineralization [1,6,9,15]. Zeolite has a microporous structure and is widely used in biomedical research and tissue engineering field [20,21].…”

Section: Introductionmentioning

confidence: 99%

Towards osteogenic differentiation of human dental pulp stem cells on PCL-PEG-PCL/zeolite nanofibrous scaffolds

Alipour

Aghazadeh

Akbarzadeh

et al. 2019

Artificial Cells, Nanomedicine, and Biotechnology

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Presently, tissue engineering has been developed as an effective option in the restoration and repair of tissue defects. One of the tissue engineering strategies is to use both biodegradable scaffolds and stimulating factors for enhancing cell responses. In this study, the effect of zeolite was assessed on cell viability, proliferation, osteo/odontogenic differentiation, and mineralization of human dental pulp stem cells (hDPSCs) cultured on poly (e-coprolactone)poly (ethylene glycol)-poly (e-caprolactone) (PCL-PEG-PCL) nanofibers. For this purpose, PCL-PEG-PCL nanofibrous scaffolds incorporated with zeolite were prepared via electrospinning. Both PCL-PEG-PCL and PCL-PEG-PCL/Zeolite nanofibrous scaffolds revealed bead-less constructions with average diameters of 430 nm and 437 nm, respectively. HDPSCs were transferred to PCL-PEG-PCL nanofibrous scaffolds containing zeolite nanoparticles. Cell adhesion and proliferation of hDPSCs and their osteo/odontogenic differentiation on these scaffolds were evaluated using MTT assay, Alizarin red S staining, and qRT-PCR assay. The results revealed that PCL-PEG-PCL/Zeolite nanofibrous scaffolds could support better cell adhesion, proliferation and osteogenic differentiation of hDPSCs and as such is expected to be a promising scaffold for bone tissue engineering applications.

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“…Adsorptions of heavy metals by Zeolites have been largely investigated lately due to its great binding characteristics (Kulkarni, Srinikethan, & Vidya, 2012), abundance, and low cost (Danehpash, Farshchi, Roayaei, Ghoddousi, & Hassani, 2018). Medical application of Zeolites would be a new possibility due to their non-toxic nature; therefore, they have successfully been used in tissue engineering as magnetic resonance imaging contrast agents, anti-microbial coverings, drug carrier systems, and growth/differentiation factors (Li, Jiao, Li, & Guo, 2015). In the study of , Zeolite coverings on titanium alloy dental implants (Ti6Al4V) showed high corrosive resistance and suppressed the discharge of aluminum and vanadium ions into the human tissues (Li, Jiao, Li, & Guo, 2015;Bedi, Beving, Zanello, & Yan, 2009;.…”

Section: Introductionmentioning

confidence: 99%

“…Medical application of Zeolites would be a new possibility due to their non-toxic nature; therefore, they have successfully been used in tissue engineering as magnetic resonance imaging contrast agents, anti-microbial coverings, drug carrier systems, and growth/differentiation factors (Li, Jiao, Li, & Guo, 2015). In the study of , Zeolite coverings on titanium alloy dental implants (Ti6Al4V) showed high corrosive resistance and suppressed the discharge of aluminum and vanadium ions into the human tissues (Li, Jiao, Li, & Guo, 2015;Bedi, Beving, Zanello, & Yan, 2009;. High capability of Zeolites as drug carriers is due to their homogenous microporous structure and also because of their multiple functional groups giving them the binding ability to drug molecules via hydrogen bonds (Amorim et al, 2012;Tavolaro, Riccio, & Tavolaro, 2013).…”

Section: Introductionmentioning

confidence: 99%

Zeolite as a Bone Bio-Modifier Carrier: An In-Vitro Study

Mousavi¹,

Nejad²,

Shamsoddin³

et al. 2019

JMBR

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Background: Zeolite is a microporous aluminosilicate compound which has been successfully used in tissue engineering. The effects of Zeolite on the morphology and functions of pre-osteoblastic MG-63 cells as new bone enhancer material is still unclear. Methods: In this vitro experimental study, MTT and Alizarin red staining test were performed on six groups of MG-63 cells which differed in Zeolite (Z) concentration and the presence or absence of Alloplast extract (A). Group A: 0.1μg/mL Z+A, Group B: 0.1μg/mL Z without A, Group C: 0.2μg/mL Z+A, Group D: 0.2μg/mL Z without A, Group E: 0.3μg/mL Z+A, Group F: 0.3μg/mL Z without A. There were also three control groups as positive control, negative control, and Alloplast control based on each related test. The data were analyzed by SPSS 20 via one-way ANOVA and Welch test. (P<0.05). Results: At 24 hours, results showed that solutions with 0.1μg/mL, 0.2μg/mL, and 0.3μg/mL Zeolite with or without Alloplast had significantly higher proliferation rates than positive control (distilled water) groups without Alloplast (p<0.001). At 72hours time point, the results showed significantly higher proliferation rates in the solutions with 0.1μg/mL, 0.2μg/mL, and 0.3μg/mL Zeolite with or without Alloplast compared to the positive control group without Alloplast (p<0.001). Conclusions: Zeolite can increase proliferation of MG-63 cells without presence of Alloplast; It seems that combination of Zeolite with Alloplast maybe enhancing proliferation and function of MG-63 cells.

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Improving the osteointegration of Ti6Al4V by zeolite MFI coating

Cited by 27 publications

References 29 publications

Zeolite-based biomaterials for biomedical application: A review

Zeolite-based biomaterials for biomedical application: A review

Towards osteogenic differentiation of human dental pulp stem cells on PCL-PEG-PCL/zeolite nanofibrous scaffolds

Zeolite as a Bone Bio-Modifier Carrier: An In-Vitro Study

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