Improving performance of simulated moving bed chromatography by fractionation and feed-back of outlet streams

Advanced Operating Strategies to Extend the Applications of Simulated Moving Bed Chromatography

“…Since the discarded portion contains higher purity product than the feed, it follows that recycling the discarded portion into the SMB improves the separation performance. The loss of yield in the PD operation was successfully recovered in the FF‐SMB , and RPD‐SMB strategies by recycling the discarded portion during the feed stage.…”

“…In the I-SMB strategy, the switching period is divided into two steps and the unit is Figure 6. Feed concentration profiles in (a) Partial-Feed [67] and ModiCon [69] strategies, (b) FF-SMB [78,79], RPD-SMB [80], and Backfill-SMB [76] strategies, (c) FeedCol strategy [74]. Solid line: extract; dashed line: raffinate.…”

Verfahren zur Enantiomerentrennung

“…B. Lit. [267][268][269][270]), die auch die Anwendung überkritischer Flüssigkeiten als mobile Phase beinhalten. [271,272] Die Verfügbarkeit dieser Varianten erweiterte das Anwendungsspektrum [273] und führte bereits zu den ersten erfolgreichen Reinigungen von Biomolekülen mittels kontinuierlicher Chromatographie.…”

Simulated moving bed separation of agarose-hydrolyzate components for biofuel production from marine biomass

“…It was reported that such a ternary separation task could be well addressed by several types of single SMB units [21][22][23][24], if they would adopt more sophisticated operation patterns and/or employ a larger number of zones than those of a classical four-zone SMB. However, it is known that the case of using simple operation pattern (i.e., a full feeding and a full product-collection) and a small number of zones is usually more advantageous in a failure rate and a life span of the process mechanical parts, compared to the case of using sophisticated operation patterns (i.e., a partial feeding and/or a partial product-collection) and/or a large number of zones [25]. For this reason, the targeted SMB of interest was set to follow a classical four-zone SMB scheme, which could be one of the most practical options for allowing the simple operation pattern (a full feeding and a full product-collection) while making zone number as small as possible.…”