Advanced Operating Strategies to Extend the Applications of Simulated Moving Bed Chromatography

BACKGROUND Spent coffee grounds, a valuable source of phenolic compounds, are considered beneficial for human health because of their antioxidative properties. The liquid extract containing phenolic compounds (such as chlorogenic and gallic acids) can be obtained via extraction using environmentally friendly organic solvent. The separation of chlorogenic and gallic acids from the liquid extract was carried out using isocratic chromatography technique in a three‐zone simulated moving bed (SMB). However, due to the low selectivity of separation, the productivity of three‐zone SMB was sacrificed to meet the purity criteria. Hence this work aimed to enhance the productivity of three‐zone SMB for the separation of chlorogenic and gallic acids via model simulation using partial feed operation and to improve the concentration of extract and raffinate products using partial collection strategy. RESULTS The full feed scenario was designed based on the triangle theory, and the partial feed patterns (initial feed, middle feed and late feed) were implemented for each operating point in the triangle diagram to investigate the possibility of increasing the feed flow rate. The maximum productivity was evaluated based on the purity criteria (≥98%) for both extract and raffinate products. Under optimal conditions, productivity was doubled to 0.24 mg min−1 L−1 for both middle feed and late feed patterns compared to that of the full feed scenario. The partial collection strategy applied to the optimal point for each operational mode significantly increased the raffinate concentration to approximately 0.02 g L−1 at the optimal time fraction for discarding the solvent. CONCLUSION This work could be a foundation for the valorization of spent coffee ground. © 2021 Society of Chemical Industry (SCI).

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“…Nevertheless. it was still possible to implement the SMB process for this separation task even with such low selectivity 34 …”

Section: Resultsmentioning

confidence: 99%

Enhanced separation of chlorogenic and gallic acids extracted from spent coffee grounds using a three‐zone simulated moving bed process with partial feed and partial collection strategies

Tangpromphan

Nakkong

Jaree

2021

J of Chemical Tech & Biotech

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“…However, also the suggestion of completely new and probably partly unexpected non‐trivial configurations can be envisaged. Promising applications of superstructure analysis are already used to evaluate and optimize the large spectrum of modified more flexible new SMB process configurations as shown in .…”

Section: Discussionmentioning

confidence: 99%

Generalizing Countercurrent Processes: Distillation and Beyond

Münzberg

Seidel‐Morgenstern

2018

Chemie Ingenieur Technik

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The implementation and exploitation of countercurrent movement between different phases is a well‐established principle to enhance the performance of separation processes. The improvements are essentially due to the establishment and application of more favorable driving forces compared to co‐current operation. The success of dedicated multistage countercurrent distillation processes has been a key motivator for the development of many other principles of countercurrent separation processes. This promoting aspect was strongly supported by the availability of graphical solutions of the underlying mass balance equations, e.g. the McCabe‐Thiele diagram. Selected applications of countercurrent separation processes are presented, which demonstrate extensions exploiting spatial and temporal sub‐structures and additional phase changes.

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“…In these stages, the costs and scale-up potential of the method become a very important issue to be considered [17]. There are prevailing resolution techniques and strategies to obtain the enantiomers in this scale including crystallization [29,30], simulated moving bed (SMB) [31], and liquid chromatography (LC) [14,22,27]. Leek H. et al [32] recently reported a strategy for large-scale isolation of enantiomers in drug discovery, affording different options that involved different chromatographic techniques together with crystallization.…”

Section: Trends In Chiral Separations On Preparative Scale In Early Pmentioning

confidence: 99%

Chiral Separations in Preparative Scale: A Medicinal Chemistry Point of View

2020

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Enantiomeric separation is a key step in the development of a new chiral drug. Preparative liquid chromatography (LC) continues to be the technique of choice either during the drug discovery process, to achieve a few milligrams, or to a scale-up during the clinical trial, needing kilograms of material. However, in the last few years, instrumental and technical developments allowed an exponential increase of preparative enantioseparation using other techniques. Besides LC, supercritical fluid chromatography (SFC) and counter-current chromatography (CCC) have aroused interest for preparative chiral separation. This overview will highlight the importance to scale-up chiral separations in Medicinal Chemistry, especially in the early stages of the pipeline of drugs discovery and development. Few examples within different methodologies will be selected, emphasizing the trends in chiral preparative separation. The advantages and drawbacks will be critically discussed.

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Advanced Operating Strategies to Extend the Applications of Simulated Moving Bed Chromatography

Cited by 42 publications

References 175 publications

Enhanced separation of chlorogenic and gallic acids extracted from spent coffee grounds using a three‐zone simulated moving bed process with partial feed and partial collection strategies

Enhanced separation of chlorogenic and gallic acids extracted from spent coffee grounds using a three‐zone simulated moving bed process with partial feed and partial collection strategies

Generalizing Countercurrent Processes: Distillation and Beyond

Chiral Separations in Preparative Scale: A Medicinal Chemistry Point of View

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