Improving influenza vaccines

Sambhara, Suryaprakash; Rappuoli, Rino

doi:10.1586/erv.12.79

Cited by 3 publications

(1 citation statement)

References 15 publications

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“…Influenza virus continues to threaten global human health with significant morbidity and mortality. Induction of influenza virus-specific neutralizing antibodies (Abs) by vaccines is the most efficient strategy, because the neutralizing Abs can conjugate virus particles at the first contact of their invasion and promote clearance by host cells ( 1 , 2 ). To generate Abs with high affinity and pathogen-neutralization ability, naïve B cells are activated and divide in response to cognate antigen and subsequently undergo rounds of somatic hypermutation and selection ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Human Vγ9Vδ2-T Cells Synergize CD4+ T Follicular Helper Cells to Produce Influenza Virus-Specific Antibody

Chen

Wen

et al. 2018

Front. Immunol.

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Human Vγ9Vδ2-T cells recognize nonpeptidic antigens and exert effector functions against microorganisms and tumors, but little is known about their roles in humoral immune response against influenza virus infection. Herein, in the coculture of autologous human B cells, dendritic cells and/or naïve CD4 T cells, and Vγ9Vδ2-T cells, we demonstrated that Vγ9Vδ2-T cells could facilitate H9N2 influenza virus-specific IgG and IgM productions in a CD4 T cell-dependent manner. Vγ9Vδ2-T cells promoted the differentiation of CXCR5+PD1+CD4+ T follicular helper (Tfh) cells, CD19+IgD−CD38++ plasma cells (PCs), and drove B cell proliferation as well as immunoglobulin class switching. Interestingly, Vγ9Vδ2-T cells acquired Tfh-associated molecules such as CXCR5, PD1, CD40L, and ICOS during influenza virus stimulation, especially in the presence of CD4 T cells. Moreover, Vγ9Vδ2-T cells promoted CD4 T cells to secrete IL-13 and IL-21, and neutralizing IL-13 and IL-21 significantly reduced the number of CD19+IgD−CD38++ PCs. Using humanized mice, we further demonstrated that Vγ9Vδ2-T cells could synergize CD4 T cells to produce influenza virus-specific antibody. Our findings provide a greater scope for Vγ9Vδ2-T cells in adaptive immunity, especially for the Tfh development and humoral immune responses against influenza virus infection.

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Section: Introductionmentioning

confidence: 99%