Improving antiproliferative effect of the anticancer drug cytarabine on human promyelocytic leukemia cells by coating on Fe3O4@SiO2 nanoparticles

Shahabadi, Nahid; Falsafi, Monireh; Mansouri, Kamran

doi:10.1016/j.colsurfb.2016.01.054

Cited by 49 publications

(25 citation statements)

References 42 publications

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“…PLLA shows two broad diffraction peaks at 16.5° and 19.9°, indicating that it was a semi-crystalline structure. Fe 3 O 4 shows diffraction peaks at 30.1°, 35.4°, 43.1°, 53.5°, 57.0°, and 62.6°, which correspond to the crystal planes (220), (311), (400), (422), (511), and (440) [ 34 ]. These characteristic peaks of Fe 3 O 4 were detected in the PLLA/Fe 3 O 4 composite scaffold, and their intensity increased with the increase of its content, which confirmed that Fe 3 O 4 was successfully introduced into the scaffold.…”

Section: Resultsmentioning

confidence: 99%

Micro Magnetic Field Produced by Fe3O4 Nanoparticles in Bone Scaffold for Enhancing Cellular Activity

et al. 2020

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The low cellular activity of poly-l-lactic acid (PLLA) limits its application in bone scaffold, although PLLA has advantages in terms of good biocompatibility and easy processing. In this study, superparamagnetic Fe3O4 nanoparticles were incorporated into the PLLA bone scaffold prepared by selective laser sintering (SLS) for continuously and steadily enhancing cellular activity. In the scaffold, each Fe3O4 nanoparticle was a single magnetic domain without a domain wall, providing a micro-magnetic source to generate a tiny magnetic field, thereby continuously and steadily generating magnetic stimulation to cells. The results showed that the magnetic scaffold exhibited superparamagnetism and its saturation magnetization reached a maximum value of 6.1 emu/g. It promoted the attachment, diffusion, and interaction of MG63 cells, and increased the activity of alkaline phosphatase, thus promoting the cell proliferation and differentiation. Meanwhile, the scaffold with 7% Fe3O4 presented increased compressive strength, modulus, and Vickers hardness by 63.4%, 78.9%, and 19.1% compared with the PLLA scaffold, respectively, due to the addition of Fe3O4 nanoparticles, which act as a nanoscale reinforcement in the polymer matrix. All these positive results suggested that the PLLA/Fe3O4 scaffold with good magnetic properties is of great potential for bone tissue engineering applications.

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Section: Resultsmentioning

confidence: 99%

Micro Magnetic Field Produced by Fe3O4 Nanoparticles in Bone Scaffold for Enhancing Cellular Activity

et al. 2020

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“…No metallic NP formulation is currently under clinical investigation for AML indications. A strategy designed to conjugate cytarabine with iron NPs coated with silica has been presented [118]. Mean particle size varied from 23 nm to 57 nm depending on the method used to measure it (microscopy or dynamic light scattering).…”

Section: Metallic Nanoparticlesmentioning

confidence: 99%

Advances in treatment formulations for acute myeloid leukemia

Briot

Roger

Thépot

et al. 2018

Drug Discovery Today

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Acute myeloid leukemia (AML) is the most common cause of leukemia-related mortality. The combination of cytarabine and anthracycline has been the gold standard of treatment over the past 40 years, but the distribution of the drugs in the body leads to severe adverse effects. Poor prognosis of older patients with AML is the consequence not only of comorbidities, but also of chemoresistance resulting from frequent secondary AML. Numerous strategies using nanotechnologies are in development to improve drug targeting, pharmacokinetics, administration route, chemoresistance, and adverse effects generally observed. Among the four new drugs approved for AML by the US Food and Drug Administration (FDA) in 2017, Vyxeos is a novel liposomal formulation of historical AML drugs. Here, we review current AML treatments and discuss how the development of new formulations will change the therapeutic armamentarium.

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“…Nanotechnology provides a flexible platform for the development of new nanomaterials that with distinct characteristics and functionalities suitable for applications in specific areas [1][2][3][4]. Of the nanomaterials studies, the magnetic nanomaterials especially the Fe 3 O 4 nanoparticles have been widely studied in the past decades because of their high potential applications in many areas especially in biomedical researches [5][6][7][8][9][10], due to their inherently ultra-fine size, low toxicity, biocompatibility and adequate magnetic properties [11].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of mesoporous magnetic nanocomposites wrapped with chitosan gatekeepers for pH-sensitive controlled release of doxorubicin

Jiang

Shen

et al. 2017

Materials Science and Engineering: C

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Multifunctional nanocarriers based on the FeO nanoparticles core and mesoporous silica shell (mSiO) were synthesized for controlled drug release through magnetic targeting and pH-sensitive performances. The developed FeO@mSiO nanocarriers exhibited a suitable size (63nm) and good magnetic responsibility, doxorubicin (DOX) could be successfully loaded into the mesoporous of FeO@mSiO via electrostatic interaction, and the drug loading content and loading efficiency are 29.3% and 93.6%, respectively. The chitosan (CS) was employed to wrap the FeO@mSiO-DOX as the blocking agent to inhibit premature drug release, and the final CS/FeO@mSiO-DOX exhibited excellent pH-sensitivity, 86.1% DOX was released within 48h at pH4.0. Furthermore, all the release behaviors fit the Higuchi model very well and a purely diffusion-controlled process played a major role on DOX release from CS/FeO@mSiO-DOX. In addition, MTT assays in human liver hepatocellular carcinoma cells (HepG2) demonstrated that the CS/FeO@mSiO-DOX had high anti-tumor activity, while the FeO@mSiO nanocarriers were practically non-toxic. Thus, our results revealed that the CS/FeO@mSiO-DOX could play an important role in the development of intracellular delivery nanodevices for cancer therapy.

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Improving antiproliferative effect of the anticancer drug cytarabine on human promyelocytic leukemia cells by coating on Fe3O4@SiO2 nanoparticles

Cited by 49 publications

References 42 publications

Micro Magnetic Field Produced by Fe3O4 Nanoparticles in Bone Scaffold for Enhancing Cellular Activity

Micro Magnetic Field Produced by Fe3O4 Nanoparticles in Bone Scaffold for Enhancing Cellular Activity

Advances in treatment formulations for acute myeloid leukemia

Synthesis and characterization of mesoporous magnetic nanocomposites wrapped with chitosan gatekeepers for pH-sensitive controlled release of doxorubicin

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