Improvements in quadriceps sensorimotor function and disability of patients with knee osteoarthritis following a clinically practicable exercise regime

Hurley, MV; Scott, David

doi:10.1093/rheumatology/37.11.1181

Cited by 232 publications

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“…Therefore, muscle atrophy is common following the onset of knee OA (4). This muscle atrophy is clinically important, because the knee extensor muscles play a role in maintaining the capacity to perform daily activities in patients with knee OA (5). In addition, the disuse and subsequent atrophy of the affected limb, due to increased inflammation and pain, may lead to a further increase in inflammation, as seen after bed rest (6) and lower limb suspension (7).…”

mentioning

confidence: 99%

Increased inflammatory cytokine expression in the vastus lateralis of patients with knee osteoarthritis

Levinger¹,

Levinger²,

Trenerry³

et al. 2011

Arthritis & Rheumatism

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Objective. Increased inflammation and pain are inseparable parts of knee osteoarthritis (OA) that may lead to disuse of the affected limb. The aim of this study was to examine the effects of knee OA on inflammationand atrophy-related genes and proteins in the vastus lateralis muscle of patients with knee OA.Methods. Nineteen patients with knee OA and 14 asymptomatic control subjects matched for age and body mass index underwent strength measurements and a muscle biopsy. Results. Knee OA resulted in greater levels of IL-6 protein (34%; P ‫؍‬ 0.002). The levels of inflammatory kinases, including STAT-3 (187%; P ‫؍‬ 0.002), p65 NF-B (156%; P ‫؍‬ 0.002), and JNK1 (179%; P ‫؍‬ 0.027), were also elevated. Furthermore, elevated expression of gene transcripts encoding MCP-1 (28%; P ‫؍‬ 0.023), TNF␣ (85%; P < 0.001), and SOCS-3 (38%; P ‫؍‬ 0.055) was observed in patients with knee OA compared with control subjects. Patients with knee OA had reduced muscle strength compared with control subjects Conclusion. Gene expression and the protein abundance of numerous muscle markers of inflammation and atrophy were elevated in patients with knee OA, and the increase in muscle inflammation was associated with a reduction in muscle strength. Given the role inflammation markers may play in muscle strength and atrophy, further studies are needed to investigate the effect of exercise intervention on skeletal muscle inflammation.

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mentioning

confidence: 99%

Increased inflammatory cytokine expression in the vastus lateralis of patients with knee osteoarthritis

Levinger¹,

Levinger²,

Trenerry³

et al. 2011

Arthritis & Rheumatism

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“…Poor muscle strength and dysfunction in the affected legs is a common feature and likely contributes to impaired quality of life through deterioration of functional capacity in people with knee OA (18,19,33). We previously demonstrated a correlation with increased protein abundance of inflammatory chemokine MCP-1 and impaired quadriceps muscle strength (7).…”

Section: Discussionmentioning

confidence: 95%

“…Further studies are needed to investigate potential nonpharmacologic (such as exercise intervention) and pharmacologic therapeutic strategies to reduce skeletal muscle inflammation and improve functional capacity in people with knee OA. Since impaired muscular function is a major determinant of functional performance such as walking (18,46), understanding the underlying mechanisms of the loss of muscle mass and function in knee OA and the effects of muscle inflammation on muscle function is important and warrants further investigation.…”

Section: Discussionmentioning

confidence: 99%

“…The vastus lateralis, being the largest component muscle of the quadriceps femoris, plays a major role in knee extension and is important for daily functioning such as walking. Consequently, the reduction in muscle strength and function, particularly of the quadriceps, can have a detrimental impact on physical function and disability in people with knee OA (18,19). However, the effects of increased proinflammatory markers in the quadriceps muscle on the performance of daily life activities such as walking are unclear and require further investigation.…”

Section: Introductionmentioning

confidence: 99%

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Association between skeletal muscle inflammatory markers and walking pattern in people with knee osteoarthritis

Levinger

Caldow

Feller

et al. 2011

Arthritis Care & Research

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Objective. Patients with knee osteoarthritis (OA) are characterized by increased muscle inflammation and altered gait. We investigated the association between proinflammatory mediators in the vastus lateralis and physical function and gait in patients with knee OA. Methods. Nineteen patients with knee OA underwent gait analysis, assessment of self-reported pain and physical function (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]), and a muscle biopsy that was taken during their knee replacement surgery. Muscle was analyzed for cellular protein inflammatory mediators, interleukin-6, monocyte chemotactic protein 1 (MCP-1), p65 NF-B, signal transducer and activator of transcription 3 (STAT-3), and JNK-1. Sagittal plane knee function, including early stance knee range of motion (ROM) and knee sagittal plane impulse, was measured using a motion analysis system. Pearson's correlation was used to assess relationships between selected variables. Results. Significant positive correlations were found between MCP-1 and self-perceived stiffness, physical function, and the total WOMAC score (P < 0.05). MCP-1 was also negatively correlated with early stance knee ROM (r ‫؍‬ ؊0.52, P ‫؍‬ 0.023). Reduced velocity was associated with elevated levels of p65 NF-B and STAT-3 (P < 0.05). Knee sagittal plane impulse was negatively correlated with JNK-1 (P ‫؍‬ 0.02), indicating reduction in knee impulse with an increased level of JNK-1. Conclusion. Increased levels of several proinflammatory mediators were correlated with altered knee function during walking as well as greater physical disability and slower gait velocity. Identification of the cellular and molecular mechanisms associated with muscle inflammation is important to better understand the underlying mechanism responsible for altered gait and function in patients with knee OA.

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“…Poca fuerza en la extremidad inferior se relaciona con un peor equilibrio 25 , y se ha visto que su desarrollo produce una mejora en la propiocepción 26 . Por otro lado, el ejercicio aeróbico mejora la capacidad del individuo en tareas que implican la transferencia del peso corporal, como caminar o subir y bajar escaleras 12 .…”

Section: Análisis De Los Estudios Seleccionados ¿Entrenamiento De Fueunclassified

Ejercicio físico como terapia no farmacológica en la artrosis de rodilla

Peinado

Cupeiro

Montero

2010

Reumatología Clínica

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RESUMEN Palabras clave:Artrosis Enfermedad articular Ejercicio Actividad física Fuerza La artrosis de rodilla es una de las enfermedades articulares más frecuentes, sus síntomas principales son dolor e incapacidad física. La regeneración del cartílago es un tratamiento todavía en desarrollo, por lo que los tratamientos actuales se centran en aliviar los síntomas. El ejercicio físico se presenta como una alternativa u opción de tratamiento barata y efectiva. Sin embargo, todavía no está claro qué tipo de ejercicio, cantidad, intensidad, etc. son más recomendables. Por lo tanto, el objetivo de esta revisión es integrar toda la información posible de cara al diseño de programas de entrenamiento para el tratamiento de la artrosis de rodilla. Todos los artículos seleccionados tras la revisión, salvo el de Talbot et al 1 , mostraron mejoras significativas en el dolor de la rodilla, en la capacidad física o en ambas variables. Sin embargo, muchos autores obvian elementos cruciales del programa, por lo que no es posible la aplicación con fines terapéuticos o para contrastar los resultados en otras muestras. Physical exercise as non pharmacologic therapy in knee osteoarthritis ABSTRACT Keywords:Osteoarthritis Joint disorder Exercise Physical activity Strength Knee osteoarthritis is one of the most frequent joint disorders, and its major symptoms are pain and physical disability. Cartilage regeneration therapies are still under development, and current treatments target pain and disability. Physical activity could be a cheap and effective therapeutic option. However, it is not yet known which types of exercise are the most beneficial, as well as its load or intensity. Therefore, the objective of this work is to integrate all the information about the design of training programs for knee osteoarthritis treatment. All of the selected articles by Talbot and colleagues (except one), showed significant improvement in knee pain, physical performance, or both. However, many authors do not describe the main elements of the programs, so its application as a therapy or for contrasting the results is not possible. IntroducciónDentro de los diferentes tipos de tratamientos que pueden emplearse en la intervención sobre la artrosis de rodilla, el ejercicio físico parece el que menos efectos secundarios o secuelas produce. Sin embargo, hay bastante controversia 2 sobre qué tipo de ejercicio es más adecuado y qué dosis son las más recomendables. Este trabajo pretende ayudar a definir, desde el punto de vista práctico, las características de los tratamientos utilizados en los estudios clínicos. Marco teóricoSe calcula que la artrosis sintomática de rodilla (definida como dolor en la mayoría de los días, además de evidencias de la N Autor para correspondencia.Correo electrónico: pedroj.benito@upm.es (P.J. Benito Peinado).enfermedad en una radiografía de la rodilla afectada) tiene una prevalencia del 11% en los individuos mayores de 65 años 3 . En España, según la Encuesta Nacional de Salud de 2003, el 10% de los españoles padece esta enfer...

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Improvements in quadriceps sensorimotor function and disability of patients with knee osteoarthritis following a clinically practicable exercise regime

Cited by 232 publications

References 0 publications

Increased inflammatory cytokine expression in the vastus lateralis of patients with knee osteoarthritis

Increased inflammatory cytokine expression in the vastus lateralis of patients with knee osteoarthritis

Association between skeletal muscle inflammatory markers and walking pattern in people with knee osteoarthritis

Ejercicio físico como terapia no farmacológica en la artrosis de rodilla

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