Improvement of skin barrier function in atopic dermatitis patients with a new moisturizer containing a ceramide precursor

Simpson, Eric L.; Böhling, Arne; Bielfeldt, S.; Bosc, Catherine; Kerrouche, Nabil

doi:10.3109/09546634.2012.713461

Cited by 74 publications

(78 citation statements)

References 25 publications

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“…This was associated with an increased level of ceramide in the SC as assessed by Raman spectroscopy. In addition, for the deepest layer of SC, a higher level of water content was measured (14).…”

Section: Dryness Body Facementioning

confidence: 99%

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A new topical panthenol-containing emollient: skin-moisturizing effect following single and prolonged usage in healthy adults, and tolerability in healthy infants

Stettler

Wagner³

et al. 2016

Journal of Dermatological Treatment

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Purpose: Two studies were conducted with a new topical panthenol-containing emollient (NTP-CE) to investigate the skin-moisturizing effect in healthy adults and tolerability in healthy infants. Methods: In Study 1 (N ¼ 44), a single skin application of NTP-CE was performed followed by a 4-week twice-daily application. Skin hydration and stratum corneum (SC) water content change (using Raman spectroscopy) were measured. In the 4-week Study 2 (N ¼ 65, aged 3-25 months), NTP-CE tolerability was assessed using a 5-point scoring system; skin hydration was determined in a subset (N ¼ 21). Results: In Study 1, mean AUC 0 À 24 h for skin capacitance change from baseline was 302.03 i.u. with NTP-CE and À15.90 i.u. in control areas (p < .001). With NTP-CE (at 4 h), the water content within the upper SC part was reduced (À45.10 vs. À13.39 g/cm 2 , p ¼ .013) and the water gradient increased (0.51 vs. 0.11 g/ cm 4 , p ¼ .036), indicating relocation of water into deeper layers. In Study 2, there was no statistically significant change from baseline in mean cutaneous tolerability scores. At days 7, 14, and 28, skin hydration had increased by 42%, 54%, and 49%, respectively (all p < .001). Conclusions: Single and prolonged NTP-CE usage is associated with sustained and deep skin moisturization. NTP-CE is well tolerated by healthy infants. ARTICLE HISTORY

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Section: Dryness Body Facementioning

confidence: 99%

“…For the same reason, no primary and secondary variables were defined. Based on historical data, it was expected that scientifically meaningful results can be obtained with the selected sample size (11)(12)(13)(14).…”

Section: Study 1: Moisturization Studymentioning

confidence: 99%

A new topical panthenol-containing emollient: skin-moisturizing effect following single and prolonged usage in healthy adults, and tolerability in healthy infants

Stettler

Wagner³

et al. 2016

Journal of Dermatological Treatment

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“…Biologics targeting B and T cells, eosinophils, IgE or TNF-a have been reported to be effective in at least subgroups of patients with AD (103). Currently, a number of emollients that should substitute missing or defective components of the skin barrier, for example ceramides and lipids, have been studied in clinical trials (104)(105)(106). The application of a lipid raft-modulating agent, miltefosine, resulted in a sustained improvement in AD and increase of regulatory T cells in the skin (107).…”

Section: Translating Research Into Therapy For Admentioning

confidence: 99%

Update in clinical allergy and immunology

Gunten

Marsland

Garnier

et al. 2012

Allergy

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In the recent years, a tremendous body of studies has addressed a broad variety of distinct topics in clinical allergy and immunology. In this update, we discuss selected recent data that provide clinically and pathogenetically relevant insights or identify potential novel targets and strategies for therapy. The role of the microbiome in shaping allergic immune responses and molecular, as well as cellular mechanisms of disease, is discussed separately and in the context of atopic dermatitis, as an allergic model disease. Besides summarizing novel evidence, this update highlights current areas of uncertainties and debates that, as we hope, shall stimulate scientific discussions and research activities in the field.Research progress goes ahead fast, and each issue of Allergy distributes a dozen of new and interesting papers providing actual research results, opinions and reviews in different fields of allergy and clinical immunology. Over time, it becomes difficult to keep an overview on the novelties and trends given by these articles. Here, we give an update aiming to summarize interesting papers published in Allergy over the last years and putting them in context with recently published work in the field. As we were not able to cover all fields, we selected three research subjects: (i) Hygiene hypothesis: the role of the microbiome in allergy; (ii) Pathogenic mechanisms of allergic diseases and their potential therapeutic implications; (iii) Atopic dermatitis (AD): skin barrier and allergic inflammation. In our view, the selected papers provide new insights in clinically and pathogenetically important research as well as novel targets and strategies for therapy that might become starting points for future research.

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“…Помимо этих новых ингредиентов, лосьон содержит увлажняющие и смягча-ющие вещества, такие как глицерин, сорбитол, пантенол и натрия гиалуронат, которые способствуют увеличе-нию содержания воды и помогают заживлению трещин на коже. В ряде зарубежных работ было показано, что применение лосьона у пациентов с АтД снижает транс-эпидермальную потерю воды в 7 раз, увеличивает гидра-тацию кожи более чем в 4 раза, уменьшает сухость кожи более чем в 2 раза, а зуд и жжение -в 3 раза [6][7][8][9].…”

Section: Introductionunclassified

Experience of Use of Special Moistening Lotion in Atopic Dermatitis

Biryukova¹,

Efimova²,

Varfolomeeva³

et al. 2014

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Научный центр здоровья детей, Москва, Российская ФедерацияВВЕДЕНИЕ Атопический дерматит (АтД) (атопическая экзема, синдром атопической экземы/дерматита) -хрониче-ское воспалительное заболевание кожи, сопровождаю-щееся зудом, которое в типичных случаях начинается в раннем детском возрасте, может продолжаться или рецидивировать в зрелом возрасте и приводит к физи-ческой и эмоциональной дезадаптации пациента и чле-нов его семьи [1].Распространенность заболевания в развитых стра-нах составляет 20% у детей и 1-3% у взрослого населе-ния [2]. Установлено, что АтД развивается у 81% детей, если больны оба родителя, у 59% -если болен один из родителей, а другой имеет аллергическую патологию дыхательных путей, и у 56% -если болен только один из родителей [3].В последние годы установлено, что нарушение барьерной функции кожи при АтД обусловлено мута-

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Improvement of skin barrier function in atopic dermatitis patients with a new moisturizer containing a ceramide precursor

Abstract: Skin barrier function and hydration were significantly improved after CRM treatment.

Cited by 74 publications

References 25 publications

A new topical panthenol-containing emollient: skin-moisturizing effect following single and prolonged usage in healthy adults, and tolerability in healthy infants

A new topical panthenol-containing emollient: skin-moisturizing effect following single and prolonged usage in healthy adults, and tolerability in healthy infants

Update in clinical allergy and immunology

Experience of Use of Special Moistening Lotion in Atopic Dermatitis

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