A new topical panthenol-containing emollient: skin-moisturizing effect following single and prolonged usage in healthy adults, and tolerability in healthy infants

Abstract

Purpose: Two studies were conducted with a new topical panthenol-containing emollient (NTP-CE) to investigate the skin-moisturizing effect in healthy adults and tolerability in healthy infants. Methods: In Study 1 (N ¼ 44), a single skin application of NTP-CE was performed followed by a 4-week twice-daily application. Skin hydration and stratum corneum (SC) water content change (using Raman spectroscopy) were measured. In the 4-week Study 2 (N ¼ 65, aged 3-25 months), NTP-CE tolerability was assessed using a 5-point scoring system; skin hydration was determined in a subset (N ¼ 21). Results: In Study 1, mean AUC 0 À 24 h for skin capacitance change from baseline was 302.03 i.u. with NTP-CE and À15.90 i.u. in control areas (p < .001). With NTP-CE (at 4 h), the water content within the upper SC part was reduced (À45.10 vs. À13.39 g/cm 2 , p ¼ .013) and the water gradient increased (0.51 vs. 0.11 g/ cm 4 , p ¼ .036), indicating relocation of water into deeper layers. In Study 2, there was no statistically significant change from baseline in mean cutaneous tolerability scores. At days 7, 14, and 28, skin hydration had increased by 42%, 54%, and 49%, respectively (all p < .001). Conclusions: Single and prolonged NTP-CE usage is associated with sustained and deep skin moisturization. NTP-CE is well tolerated by healthy infants. ARTICLE HISTORY

Topical use of dexpanthenol: a 70th anniversary article

“…In another set of two studies, Stettler et al (34) investigated the skin moisturizing effect of the dexpanthenol-containing emollient in healthy adults with dry skin and in healthy infants. Study 1 (N ¼ 44) was a randomized, intra-individual comparison study while study 2 was a non-comparative trial (N ¼ 65, age: 3-25 months).…”

Review of Modern Techniques for the Assessment of Skin Hydration

“…The use of RS to examine lateral packing and conformational order of SC lipids is well established, as well as in evaluations of SC water profiles [198], and determinations of lipid/protein ratio through calculations of lipid and protein intensity peaks [199]. Such attributes have been employed in a variety of skin-related studies of barrier permeability in dry skin conditions [199][200][201][202], substance penetration [203], and evaluations of the efficacy of moisturisers [204] and anti-ageing ingredients and formulations [56,205].…”

A new topical panthenol-containing emollient for maintenance treatment of childhood atopic dermatitis: results from a multicenter prospective study

“…Results from Raman spectroscopy implied a NTP-CE-mediated relocation of the water molecules from upper to deeper layers of the stratum corneum leading to deep moisturization. NTP-CE also exerted favorable effects on the skin microflora (13,14). Moreover, in a study in healthy infants (aged 3-25 months) twice-daily application of NTP-CE for 4 weeks was well-tolerated and significantly increased skin hydration (14).…”

“…A new topical panthenol-containing emollient (NTP-CE, Bepanthen V R SensiDaily) (Bayer Consumer Care AG, Basel, Switzerland) has been developed for subjects with non-inflammatory dry and sensitive skin conditions, such as AD while in remission phase (13,14). Previous studies with NTP-CE in healthy adult subjects showed that its application is associated with significant improvements in skin barrier restoration, skin moisturization, and intercellular lipid layer organization in the stratum corneum.…”