Improvement of osseointegration of titanium dental implant surfaces modified with CO ions: a comparative histomorphometric study in beagle dogs

Maeztu, M.A. De; Braceras, I.; Alava, J.I.; Gay‐Escoda, Cosme

doi:10.1016/j.ijom.2008.01.010

Cited by 36 publications

(32 citation statements)

References 18 publications

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“…Until now, almost all FEA studies of dental implant treatment assumed a bone-implant contact (BIC) ratio of 100% (6)(7)(8). However, the BIC ratio is not 100%: the true value was reported to be 45 ± 16% in one study (9) and 40 to 70% in other studies (10,11). Further, the recent discovery of titanium photofunctionalization has significantly improved the BIC ratio, thus enabling unprecedented enhancement of osseointegration (12,13).…”

Section: Introductionmentioning

confidence: 99%

Three-dimensional finite element analysis of the effects of implant diameter and photofunctionalization on peri-implant stress

Ohyama

Yasuda

Shibuya

et al. 2017

Journal of Oral Science

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Previous finite element analyses of peri-implant stress assumed a bone-implant contact (BIC) ratio of 100%, even though the BIC ratio is known to be approximately 50% or less. However, the recent development of ultraviolet treatment of titanium immediately before use, known as photofunctionalization, significantly increased the BIC ratio, to 98.2%. We used a unique finite element analysis model that enabled us to examine the effects of different BIC ratios on peri-implant stress. A three-dimensional model was constructed under conditions of vertical or oblique loading, an implant diameter of 3.3, 3.75, or 5.0 mm, and a BIC ratio of 53.0% or 98.2%. Photofunctionalization and larger implant diameters were associated with reduced stress on surrounding tissues. Under vertical loading, photofunctionalization had a greater effect than increased implant diameter on stress reduction. Under oblique loading, increased implant diameter had a greater effect than photofunctionalization on stress reduction.

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Section: Introductionmentioning

confidence: 99%

Three-dimensional finite element analysis of the effects of implant diameter and photofunctionalization on peri-implant stress

Ohyama

Yasuda

Shibuya

et al. 2017

Journal of Oral Science

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“…Numerous researchers have realized that the existence of C-OH bond is beneficial towards hydrophilicity 52) . Typically, surface modification in dental implants, particularly in titanium implants, can enhance osseointegration and reduce healing time [53][54][55] . There is a close association between modified titanium surface and osteoblast cell adhesion, proliferation, differentiation and mineralization on its surface 56,57) .…”

Section: Discussionmentioning

confidence: 99%

A novel cold atmospheric pressure air plasma jet for peri-implantitis treatment: An <i>in vitro</i> study

Guo

Zhou

et al. 2018

Dental Materials Journal

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Peri-implantitis is difficult to treat in clinical settings; this is not only because it is a site-specific infectious disease but also because it impedes osseointegration. In this study, a novel cold atmospheric pressure air plasma jet (CAPAJ) was applied to study the treatment of peri-implantitis in vitro. CAPAJ treated the samples for 2, 4 and 6 min, respectively. To evaluate the titanium surface characteristics, the surface elemental composition (X-ray photoelectron spectroscopy [XPS]), roughness and hydrophilicity were evaluated in each group. Concurrently, the sterilization and osseointegration effect of CAPAJ were also examined. Results revealed that after CAPAJ modification, roughness and hydrophilicity of titanium surfaces were significantly increased. Moreover, XPS results demonstrated that the C1s peak was reduced and N1s and O1s peaks were obviously improved. More importantly, CAPAJ showed favorable sterilization and bone formation effects. CAPAJ seemed a simpler and more efficient strategy for the peri-implantitis treatment.

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“…However, it remains uncertain why bone tissue fails to form around the entire implant surface, with bone-implant contact percentages reported at 45% ± 16% 5) , or between 50% and 75% [6][7][8] , in the literature. Most implants fail due to incomplete bone formation at the surface or early/late destructive changes at the bone-implant interface 9,10) .…”

Section: Introductionmentioning

confidence: 99%

Titanium Delivery of Osteoblastic Cell Sheets: An <i>In Vitro</i> Study

Kanuru¹,

Sugita

Ikeda³

et al. 2018

J. Hard Tissue Biology.

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Abstract:We hypothesized that maximizing the number of cells on titanium implants would enhance its biological and bone-integration capabilities as a bone anchorage device. The purpose of this study was to determine the feasibility of fabricating osteoblastic cell sheets, combining them with titanium materials, and controlling their function. Rat femurderived bone marrow cells cultured on poly(N-isopropylacrylamide) (PIPAAm) dishes were harvested in sheet form by exploiting temperature-responsive hydrophobic to hydrophilic conversion of the dish and subsequently transferring them to titanium disks. Cell sheets remained adherent and spread on micro-roughened titanium surfaces but not on machined surfaces. The post-transfer alkaline phosphatase (ALP) activity of the cell sheets responded to the presence or absence of dexamethasone and was increased by pre-treatment with the osteogenic amino-acid derivative N-acetyl cysteine (NAC) in a dose-dependent manner. Double-layering cell sheets on titanium enhanced ALP activity twofold compared to single sheets. Titanium implants enfolded with autologous osteoblastic cell sheets showed 2.5-times stronger boneimplant integration than controls in a rat femur model. We show that micro-roughened titanium materials can be combined with osteoblastic cell sheets to improve cellular supply at the implant interface. Furthermore, cell sheet function can be controlled and enhanced by biologic agents and technical modifi cations.

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Improvement of osseointegration of titanium dental implant surfaces modified with CO ions: a comparative histomorphometric study in beagle dogs

Cited by 36 publications

References 18 publications

Three-dimensional finite element analysis of the effects of implant diameter and photofunctionalization on peri-implant stress

Three-dimensional finite element analysis of the effects of implant diameter and photofunctionalization on peri-implant stress

A novel cold atmospheric pressure air plasma jet for peri-implantitis treatment: An <i>in vitro</i> study

Titanium Delivery of Osteoblastic Cell Sheets: An <i>In Vitro</i> Study

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