A novel cold atmospheric pressure air plasma jet for peri-implantitis treatment: An &lt;i&gt;in vitro&lt;/i&gt; study

Yu, Yang; Guo, Junming; Zhou, Xuan; Liu, Zhiqiang; Wang, Chenbao; Wang, Kaile; Zhang, Jue; Wang, Zuomin

doi:10.4012/dmj.2017-030

Cited by 35 publications

(39 citation statements)

References 64 publications

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“…Ambient air (principally oxygen and nitrogen) was the working gas used in this study. As both oxygen and nitrogen are diatomic, and as oxygen is highly electronegative, excitation with air is more difficult than that with noble gases [19]. Therefore, a power supply delivering a high repetition rate (a pulsed-power generator with semiconductor switches) was used for the NTAAP device in this study [20].…”

Section: Discussionmentioning

confidence: 99%

“…Noble gases such as argon or helium, or mixtures thereof with oxygen, are commonly used and have been associated with efficient generation of reactive species [14][15][16][17], although additional equipment (such as a gas bottle) is required for this. Although ambient air can serve as the working gas, only a few such devices have been developed because of the difficulty in controlling the excitation conditions [19]. Therefore, a new NTAP jet device using ambient air as the working gas was developed.…”

Section: Introductionmentioning

confidence: 99%

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Singlet oxygen generated by a new nonthermal atmospheric pressure air plasma device exerts a bactericidal effect on oral pathogens

et al. 2019

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Oral diseases generally have certain bacteria associated with them. Non-thermal atmospheric pressure plasma (NTAP), generated at atmospheric pressure and room temperature, incorporates several molecules, including reactive oxygen species, that can inactivate various bacteria including oral pathogens. For this reason, several NTAP devices have been developed to treat oral diseases. Use of noble gases can enhance the bactericidal efficacy of NTAP, but this requires additional gas supply equipment. Therefore, a new NTAP device that employs ambient air as the working gas was developed. The device generates non-thermal atmospheric pressure air plasma. Here, the singlet oxygen (1 O 2) levels generated, their bactericidal effects on oral pathogens (Streptococcus mutans, Porphyromonas gingivalis, and Enterococcus faecalis), and the bacterial oxidative stress they imposed were measured. 1 O 2 generation in phosphatebuffered saline was assessed qualitatively using electron spin resonance (ESR) spectroscopy, and bactericidal efficacy was evaluated by counting of colony-forming units/mL. Bacterial oxidative stress was determined by measurement of hydrogen peroxide (H 2 O 2) and superoxide dismutase (SOD) activity. ESR indicated that the level of 1 O 2 increased significantly and time-dependently, and was inversely correlated with distance, but the bactericidal effects were correlated only with treatment time (not distance) as H 2 O 2 increased and SOD levels decreased, suggesting that the new device has potential applicability for treatment of oral disease.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Singlet oxygen generated by a new nonthermal atmospheric pressure air plasma device exerts a bactericidal effect on oral pathogens

et al. 2019

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“…Cold plasma also has significant effect on titanium structures in the oral cavity. Here, CAP should increase hydrophilicity and also the roughness of titanium surfaces [82]. Both these aspects can improve cell adhesion, proliferation, and differentiation of osteoblasts, and these three factors can provide faster osteointegration [83].…”

Section: Cold Plasma In Dental Medicinementioning

confidence: 99%

“…Effects of CAP application to dental and oral cavity structures under in vitro and ex vivo conditions are listed in Table 3. [81]; HDBD device/Ar [82]; plasma jet device [85] Increased dentin binding [80]; strengthening of links between fibre-reinforced posts and composite core material [81]; increase of hydrophilicity in titanium [82] and zircone […”

Section: Cold Plasma In Dental Medicinementioning

confidence: 99%

Cold Atmospheric Plasma: A Powerful Tool for Modern Medicine

Braný

Dvorska

Halašová

et al. 2020

IJMS

211

138

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Cold atmospheric plasma use in clinical studies is mainly limited to the treatment of chronic wounds, but its application in a wide range of medical fields is now the goal of many analyses. It is therefore likely that its application spectrum will be expanded in the future. Cold atmospheric plasma has been shown to reduce microbial load without any known significant negative effects on healthy tissues, and this should enhance its possible application to any microbial infection site. It has also been shown to have anti-tumour effects. In addition, it acts proliferatively on stem cells and other cultivated cells, and the highly increased nitric oxide levels have a very important effect on this proliferation. Cold atmospheric plasma use may also have a beneficial effect on immunotherapy in cancer patients. Finally, it is possible that the use of plasma devices will not remain limited to surface structures, because current endeavours to develop sufficiently miniature microplasma devices could very likely lead to its application in subcutaneous and internal structures. This study summarises the available literature on cold plasma action mechanisms and analyses of its current in vivo and in vitro use, primarily in the fields of regenerative and dental medicine and oncology.

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“…The hybrid plasma devices are currently applied only at the experimental level [ 2 ]. Depending on its settings, each device would have several effects on biomedical applications [ 12 ]. Considering the low temperature of application, as well as the acceptable thermal damage to tissues [ 13 , 14 , 15 , 16 ], CAP has been suggested as a promising device, not only for systemic biomedical treatments, but also as a chairside approach [ 2 , 17 ] for the treatment of different oral diseases.…”

Section: Overview Of Plasma Features and Functionsmentioning

confidence: 99%

The Emerging Role of Cold Atmospheric Plasma in Implantology: A Review of the Literature

Hui¹,

Perrotti

Iaculli

et al. 2020

Nanomaterials

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In recent years, cold atmospheric plasma (CAP) technologies have received increasing attention in the field of biomedical applications. The aim of this article is to review the currently available literature to provide an overview of the scientific principles of CAP application, its features, functions, and its applications in systemic and oral diseases, with a specific focus on its potential in implantology. In this narrative review, PubMed, Medline, and Scopus databases were searched using key words like “cold atmospheric plasma”, “argon plasma”, “helium plasma”, “air plasma”, “dental implants”, “implantology”, “peri-implantitis”, “decontamination”. In vitro studies demonstrated CAP’s potential to enhance surface colonization and osteoblast activity and to accelerate mineralization, as well as to determine a clean surface with cell growth comparable to the sterile control on both titanium and zirconia surfaces. The effect of CAP on biofilm removal was revealed in comparative studies to the currently available decontamination modalities (laser, air abrasion, and chlorhexidine). The combination of mechanical treatments and CAP resulted in synergistic antimicrobial effects and surface improvement, indicating that it may play a central role in surface “rejuvenation” and offer a novel approach for the treatment of peri-implantitis. It is noteworthy that the CAP conditioning of implant surfaces leads to an improvement in osseointegration in in vivo animal studies. To the best of our knowledge, this is the first review of the literature providing a summary of the current state of the art of this emerging field in implantology and it could represent a point of reference for basic researchers and clinicians interested in approaching and testing new technologies.

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A novel cold atmospheric pressure air plasma jet for peri-implantitis treatment: An <i>in vitro</i> study

Cited by 35 publications

References 64 publications

Singlet oxygen generated by a new nonthermal atmospheric pressure air plasma device exerts a bactericidal effect on oral pathogens

Singlet oxygen generated by a new nonthermal atmospheric pressure air plasma device exerts a bactericidal effect on oral pathogens

Cold Atmospheric Plasma: A Powerful Tool for Modern Medicine

The Emerging Role of Cold Atmospheric Plasma in Implantology: A Review of the Literature

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