Improvement of memory and neurological deficit with Ocimum basilicum L. extract after ischemia reperfusion induced cerebral injury in mice

Singh, Varinder; Krishan, Pawan; Shri, Richa

doi:10.1007/s11011-018-0215-5

Cited by 28 publications

(14 citation statements)

References 39 publications

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“…Acute cerebral infarction can cause severe brain damage [ 17 , 18 ]. Some of the microRNAs that are proposed to be expressed in the brain will also change.…”

Section: Discussionmentioning

confidence: 99%

[Retracted] Expression of miR‐210, miR‐137, and miR‐153 in Patients with Acute Cerebral Infarction

Tian

Zhao

et al. 2021

BioMed Research International

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Aim. To explore the expression levels of miR-210, miR-137, and miR-153 in patients with acute cerebral infarction. Material and Methods. 76 patients with acute cerebral infarction treated in our hospital from April 2016 to October 2017 were enrolled as the observation group. Another 64 normal patients were selected as the control group. The patients were divided into the death and survival groups based on 1-year mortality of patients. qRT-PCR was used to detect the expression of miR-210, miR-137, and miR-153 in the serum of each group. Receiver operating characteristic (ROC) curve was employed to analyze the diagnostic value and predictive value of miR-210, miR-137 and miR-153 death in patients. The correlation between miR-210, miR-137, and miR-153 in the serum of the observation group was analyzed by Pearson’s test. Results. Levels of miR-210 and miR-137 in the observation group were significantly lower than those in the control group, while levels of miR-153 in the observation group were significantly higher than those in the control group (all P < 0.05 ). The ROC curve of diagnosis of acute cerebral infarction showed that the area under curve of miR-210 was 0.836, that of miR-137 was 0.843, and that of miR-153 was 0.842. The 1-year survival rate was 71.05%. The 1-year survival of the low-expression group of miR-210 and miR-137 was significantly lower than that of the high-expression group, while the 1-year survival of the low-expression group of miR-153 was significantly higher than that of the high-expression group (all P < 0.05 ). The ROC curve for predicting death showed that the area under curve of miR-210 was 0.786, that of miR-137 was 0.824, and that of miR-153 was 0.858. Pearson’s correlation analysis showed that the expression of miR-210 was positively correlated with that of miR-137, while miR-137 was negatively correlated with that of miR-153 and miR-210 was negatively correlated with that of miR-153. Conclusion. miR-210, miR-137, and miR-153 have a certain value in the diagnosis and prediction of 1-year death of acute cerebral infarction and may be potential diagnostic and predictive indicators.

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“…Acute cerebral infarction can cause severe brain damage [ 17 , 18 ]. Some of the microRNAs that are proposed to be expressed in the brain will also change.…”

Section: Discussionmentioning

confidence: 99%

[Retracted] Expression of miR‐210, miR‐137, and miR‐153 in Patients with Acute Cerebral Infarction

Tian

Zhao

et al. 2021

BioMed Research International

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“…In addition, it is used for medicinal purposes due to its antidepressant, anxiolytic, sedative activities (10,11). O. basilicum as a therapeutic supplement has been investigated in many animal models of cognitive deficits (12,13). Recently, the therapeutic efficacy of O. basilicum against impairment of memory function in animal model of Multiple sclerosis was reported (14).…”

Section: Introductionmentioning

confidence: 99%

Ocimum basilicum (Basil) Modulates Apoptosis and Neurogenesis in Olfactory Pulp of Mice Exposed to Chronic Unpredictable Mild Stress

et al. 2020

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Background: Ocimum basilicum (O. basilicum) was described to have antidepressant and anxiolytic activities. Although the relationship between the main olfactory bulb (MOB) and depression was recently reported, the chronic stress-induced dysfunction of the MOB is not clearly described. Objectives: This study aimed to assess the efficacy of inhalation of O. basilicum essential oils in improving chronic unpredictable mild stress (CUMS)-induced changes in MOB of mice and understand the mechanism underlying such effect. Materials and Methods: Adult male mice (n=40) were assigned into four groups included the control, CUMS-exposed, CUMS + fluoxetine (FLU), CUMS + O. basilicum. Behavioral changes, serum corticosterone level, and gene expression of GFAP, Ki 67, and caspase-3 were assessed using real-time PCR (RT-PCR). Histopathological and immunochemical examination of the MOB was performed. Results: FLU and O. basilicum significantly down-regulated (p = 0.002, p<0.001) caspase-3 gene expression indicating reduced apoptosis and up-regulated (p = 0.002, p < 0.001) Ki67 gene expression indicating enhanced neurogenesis in MOB, respectively. FLU and O. basilicum-treated mice markedly improved MOB mitral cell layer distortion and shrinkage induced by CUMS. Conclusion: O. basilicum relieved both biochemically and histopathological chronic stress-induced changes in the main olfactory bulb possibly through up-regulation of gene expression of GFAP and Ki67 and down-regulation of caspase-3 in the MOB.

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“…The extract also decreased cerebral infarct size and oxidative stress in mice. The extract contained high total phenol content, and possessed strong antioxidant effects [102][103].…”

Section: Ocimum Basilicummentioning

confidence: 99%

Medicinal Plants with neuroprotective effects

Al-Snafi¹

2021

GSC Biol. and Pharm. Sci.

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Neuroprotection is the preservation of the structure and function of neurons from insults from cellular injuries caused by a variety of agents or neurodegenerative diseases. Medicinal plants possess neuroprotective effects via mechanisms that include inhibiting protein-based deposit accumulation, oxidative stress, and neuroinflammation, and correcting defects of neurotransmitters such as acetylcholine and dopamine [1-3]. The current review will highlight the neuroprotective effects of medicinal plants.

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Improvement of memory and neurological deficit with Ocimum basilicum L. extract after ischemia reperfusion induced cerebral injury in mice

Cited by 28 publications

References 39 publications

[Retracted] Expression of miR‐210, miR‐137, and miR‐153 in Patients with Acute Cerebral Infarction

[Retracted] Expression of miR‐210, miR‐137, and miR‐153 in Patients with Acute Cerebral Infarction

Ocimum basilicum (Basil) Modulates Apoptosis and Neurogenesis in Olfactory Pulp of Mice Exposed to Chronic Unpredictable Mild Stress

Medicinal Plants with neuroprotective effects

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