Improvement of Intestinal Permeability With Alanyl-Glutamine in Hiv Patients:

Leite, Raquel Crosara Maia; Lima, Noélia L.; Leite, Christiane Araujo Chaves; Farhat, Calil Kairalla; Guerrant, Richard L.; Lima, Aldo Ângelo Moreira

doi:10.1590/s0004-28032013000100011

Cited by 17 publications

(13 citation statements)

References 33 publications

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“…Glutamine is the main fuel used by intestinal mucosa cells and other rapidly proliferating tissues (37). Because of its superior physicochemical solubility and favorable thermal stability in acid medium (38), glutamine was replaced by dipeptide AG. It is well established that glutamine absorption is enhanced after the ingestion of AG compared to the free amino acids (39).…”

Section: Discussionmentioning

confidence: 99%

Alanyl-glutamine protects the intestinal barrier function in trained rats against the impact of acute exhaustive exercise

Freitas

Silva

et al. 2020

Braz J Med Biol Res

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Strenuous exercise triggers deleterious effects on the intestinal epithelium, but their mechanisms are still uncertain. Here, we investigated whether a prolonged training and an additional exhaustive training protocol alter intestinal permeability and the putative effect of alanyl-glutamine (AG) pretreatment in this condition. Rats were allocated into 5 different groups: 1) sedentary; 2 and 3) trained (50 min per day, 5 days per week for 12 weeks) with or without 6 weeks oral (1.5 g/kg) AG supplementation; 4 and 5) trained and subjected to an additional exhaustive test protocol with or without oral AG supplementation. Venous blood samples were collected to determine gasometrical indices at the end of the 12-week protocol or after exhaustive test. Lactate and glucose levels were determined before, during, and after the exhaustive test. Ileum tissue collected after all experimental procedures was used for gene expression analysis of Zonula occludens 1 (ZO-1), occludin, claudin-2, and oligopeptide transporter 1 (PepT-1). Intestinal permeability was assessed by urinary lactulose/mannitol test collected after the 12-week protocol or the exhaustive test. The exhaustive test decreased pH and base excess and increased pCO 2. Training sessions delayed exhaustion time and reduced the changes in blood glucose and lactate levels. Trained rats exhibited upregulation of PEPT-1, ZO-1, and occludin mRNA, which were partially protected by AG. Exhaustive exercise induced intestinal paracellular leakage associated with the upregulation of claudin-2, a phenomenon protected by AG treatment. Thus, AG partially prevented intestinal training adaptations but also blocked paracellular leakage during exhaustive exercise involving claudin-2 and occludin gene expression.

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Section: Discussionmentioning

confidence: 99%

Alanyl-glutamine protects the intestinal barrier function in trained rats against the impact of acute exhaustive exercise

Freitas

Silva

et al. 2020

Braz J Med Biol Res

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“…[37][38][39][40][41] Amino acid supplementation with glutamine has been shown to improve intestinal permeability in AIDS patients. 12,42 Thus, given these data, investigating the effects of amino acid supplementation not only on plasma concentrations of amino acids but also on microbial translocation and immune activation may be worthwhile.…”

Section: Discussionmentioning

confidence: 99%

Amino Acid Concentrations in HIV-Infected Youth Compared to Healthy Controls and Associations with CD4 Counts and Inflammation

Ziegler

Judd

Ruff

et al. 2017

AIDS Research and Human Retroviruses

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Amino acids play critical roles in metabolism, cell function, body composition and immunity, but little data on plasma amino acid concentrations in HIV are available. We evaluated plasma amino acid concentrations and associations with CD4 counts and inflammatory biomarkers in HIV-infected youth. HIV-infected subjects with a high (≥500 cells/mm) and low (<500 cells/mm) current CD4 T cell counts were compared to one another and to a matched healthy control group. Plasma concentrations of 19 amino acids were determined with an amino acid analyzer. Plasma levels of interleukin-6, tumor necrosis factor receptor-I, and soluble vascular cellular adhesion molecule-I were also measured. Seventy-nine HIV-infected subjects (40 and 39 with high and low CD4 T cell counts, respectively) and 40 controls were included. There were no differences in amino acid concentrations between HIV-infected subjects with high or low CD4 T cell counts. When combined, the HIV-infected group exhibited significantly lower median plasma concentrations compared to controls for total, essential, branched-chain and sulfur amino acids, as well as for 12 individual amino acids. Glutamate was the only amino acid that was higher in the HIV-infected group. There were no significant correlations between amino acid endpoints and inflammatory biomarkers for either HIV-infected group or controls. Plasma amino acid concentrations were lower in HIV-infected youth compared to healthy controls, regardless of immune status, while glutamate concentrations were elevated. These findings can inform future interventional studies designed to improve metabolic and clinical parameters influenced by amino acid nutriture.

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“…Как известно, антиретровирусная терапия сама может вносить определенный вклад в развитие нарастающей недостаточности питания и инфекционных осложнений у данной категории пациентов, что обусловлено присоединением синдрома нарушенного пищеварения в виде мальдигестии и мальабсорбции, а также повышенным риском транслокации условно-патогенной кишечной микрофлоры в системный кровоток на фоне повышения проницаемости слизистой оболочки кишечника [7]. По существующим в настоящее время представлениям, коррекция дефицита L-глутамина -один из важных компонентов адъювантной терапии ВИЧ-инфицированных пациентов в рамках общей стратегии нутриционной поддержки [8][9][10][11].…”

Section: парафармакологические эффекты L-глутаминаunclassified

Glutamine and its derivatives in the correction of metabolic disorders in HIV-infected patients (review)

Luft

Матвеевич²,

Дмитриев

et al. 2020

Clinical nutrition and metabolism

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It has been established that HIV-infection is associated with progressive deficiency of L-glutamine followed by immune dysfunction, reduced body mass and muscle strength, morphological disorders and functional disintegration of the intestine, as well as neurological disorders. According to current ideas, correction of L-glutamine deficiency is one of the important components of adjuvant therapy for HIV-infected patients within general nutritional support strategy. This measure helps to slow development of AIDS, reduce side effects of antiretroviral therapy and enhance effectiveness.

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Improvement of Intestinal Permeability With Alanyl-Glutamine in Hiv Patients:

Cited by 17 publications

References 33 publications

Alanyl-glutamine protects the intestinal barrier function in trained rats against the impact of acute exhaustive exercise

Alanyl-glutamine protects the intestinal barrier function in trained rats against the impact of acute exhaustive exercise

Amino Acid Concentrations in HIV-Infected Youth Compared to Healthy Controls and Associations with CD4 Counts and Inflammation

Glutamine and its derivatives in the correction of metabolic disorders in HIV-infected patients (review)

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