Improvement of Glibenclamide Water Solubility by Nanoparticle Preparation

Vaculíková, Eliška; Pokorná, Aneta; Plachá, Daniela; Pisárčik, Martin; Dědková, Kateřina; Peikertová, Pavlína; Devı́nsky, Ferdinand; Jampílek, Josef

doi:10.1166/jnn.2019.15876

Cited by 8 publications

(4 citation statements)

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“…Therefore, smaller amounts of substances can be used, which allows decreasing dose-dependent toxicity and various side effects. In addition, many formulations also protect bioactive molecules from degradation [19,20,24,25,28,29,31,34,35,36,37,38,39,40,41,42]. The enhancement of bioavailability could be achieved by the improved solubility of bioactive compounds under gastrointestinal (GI) conditions, their protection from the chemical conditions in the GI tract, and controlled release within the GI tract, or by an improved transfer through the intestinal wall, and the particle size, surface properties, and physical state of the nanomaterials used in food supplements are crucial characteristics affecting their final nutritional value [43].…”

Section: Introductionmentioning

confidence: 99%

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

2019

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Dietary supplements and foods for special medical purposes are special medical products classified according to the legal basis. They are regulated, for example, by the European Food Safety Authority and the U.S. Food and Drug Administration, as well as by various national regulations issued most frequently by the Ministry of Health and/or the Ministry of Agriculture of particular countries around the world. They constitute a concentrated source of vitamins, minerals, polyunsaturated fatty acids and antioxidants or other compounds with a nutritional or physiological effect contained in the food/feed, alone or in combination, intended for direct consumption in small measured amounts. As nanotechnology provides “a new dimension” accompanied with new or modified properties conferred to many current materials, it is widely used for the production of a new generation of drug formulations, and it is also used in the food industry and even in various types of nutritional supplements. These nanoformulations of supplements are being prepared especially with the purpose to improve bioavailability, protect active ingredients against degradation, or reduce side effects. This contribution comprehensively summarizes the current state of the research focused on nanoformulated human and veterinary dietary supplements, nutraceuticals, and functional foods for special medical purposes, their particular applications in various food products and drinks as well as the most important related guidelines, regulations and directives.

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Section: Introductionmentioning

confidence: 99%

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

2019

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“…This field is constantly growing and provides/specializes in the development of materials with unique dimensions and thus unique properties that have enabled significant breakthroughs in many fields of human activity and have entered medicine and biological engineering. Nanoscale materials change their physical and chemical properties [54][55][56]; in this way, a number of industrial, pharmaceutical, and medical products have been improved and innovated [57][58][59][60][61][62][63][64][65][66][67] including various biocompatible NCPs for the construction of medical implants. The success of all these innovative biomedical applications is reflected in the size of the international nanomedicine market, which is estimated at $293.1 billion in 2022 and growing to $350.8 billion in 2025.…”

Section: Applied Nanomaterialsmentioning

confidence: 99%

Advances in Use of Nanomaterials for Musculoskeletal Regeneration

Jampílek

Plachá

2021

Pharmaceutics

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Since the worldwide incidence of bone disorders and cartilage damage has been increasing and traditional therapy has reached its limits, nanomaterials can provide a new strategy in the regeneration of bones and cartilage. The nanoscale modifies the properties of materials, and many of the recently prepared nanocomposites can be used in tissue engineering as scaffolds for the development of biomimetic materials involved in the repair and healing of damaged tissues and organs. In addition, some nanomaterials represent a noteworthy alternative for treatment and alleviating inflammation or infections caused by microbial pathogens. On the other hand, some nanomaterials induce inflammation processes, especially by the generation of reactive oxygen species. Therefore, it is necessary to know and understand their effects in living systems and use surface modifications to prevent these negative effects. This contribution is focused on nanostructured scaffolds, providing a closer structural support approximation to native tissue architecture for cells and regulating cell proliferation, differentiation, and migration, which results in cartilage and bone healing and regeneration.

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“…In this study, a chemical bonding method was used to assemble mPEG and ICA into an mPEG-ICA polymer, and then dialysis was used to physically wrap the ICA and form stable nanoparticles [30]. Nanoparticles can significantly improve the water solubility of ICA and can realize the long circulation of nanoparticles in the body [31,32]. Compared with mPEG-ICA nanoparticles, ICA-loaded mPEG-ICA nanoparticles have many significant advantages.…”

Section: Inflammatory Cytokine Mrna In Lps-induced H9c2 Cellsmentioning

confidence: 99%

Preparation of ICA-loaded mPEG-ICA nanoparticles and their application in the treatment of LPS-induced H9c2 cell damage

et al. 2021

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Hydrophilic polyethylene glycol monomethyl ether (mPEG) was grafted onto Icariin (ICA) by succinic anhydride to form a polyethylene glycol-Icariin (mPEG-ICA) polymer. The structure of the polymer was characterized by Fourier transform infrared spectroscopy (FT-IR) and nuclear magnetic resonance spectroscopy (NMR). mPEG-ICA nanoparticles loaded with ICA were prepared by physical embedding of ICA by dialysis. The particle size was determined to be (220 ± 13.7) nm, and the ζ potential was (2.30 ± 1.33) mV by dynamic light scattering (DLS). Under a transmission electron microscope (TEM), the nanoparticles were spherical, and the morphology was regular. In the medium with pH 7.4, the drug release rate of mPEG-ICA nanoparticles reached (52.80 ± 1.70)% within 72 h. At pH 6.8, the cumulative drug release of nanoparticles reached (75.66 ± 0.17)% within 48 h. Treatment of the nanoparticles with LPS-treated H9c2 cells maintained cell viability, reduced LDH release and exerted antiapoptotic effects. Moreover, ICA-loaded mPEG-ICA nanoparticles significantly decreased the mRNA expression of the myocardial inflammatory cytokines TNF-α, IL-1β and IL-6M. In conclusion, ICA-loaded mPEG-ICA nanoparticles protected against LPS-induced H9c2 cell injury.

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Improvement of Glibenclamide Water Solubility by Nanoparticle Preparation

Cited by 8 publications

References 0 publications

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

Potential of Nanomaterial Applications in Dietary Supplements and Foods for Special Medical Purposes

Advances in Use of Nanomaterials for Musculoskeletal Regeneration

Preparation of ICA-loaded mPEG-ICA nanoparticles and their application in the treatment of LPS-induced H9c2 cell damage

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