“…Prematurity (<37 weeks), intra-uterine growth retardation (<10th percentile), hypoxia, low socio-economic status and poor compliance with treatment all predicted poorer developmental improvement. Houtzager et al 6 found that children born small for gestational age or at less than 28 weeks gestation were more likely to improve, but in contrast, Bode et al 7 found that the correlation between scores at 2 and 4 years of age was strongest in those born <27 weeks, and weakest in the term control children. Only 19% of children who had been born prematurely changed developmental classification, with two thirds showing improvement.…”