Improvement of dermal parameters in aged skin after oral use of a nutrient supplement

Addor, Flávia Alvim Sant’Anna; Vieira, Juliana Cotta; Melo, Camila Sirieiro Abreu

doi:10.2147/ccid.s150269

Cited by 26 publications

(34 citation statements)

References 22 publications

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“…Thus, maintenance of the amount of collagen and hyaluronic acid in the body may aid in the prevention of aging. Therefore, in order to prevent various phenomena caused by a decrease in collagen and hyaluronic acid, namely an increase in wrinkles in the skin and decrease in the cartilage in joints, many cosmetics and health foods containing collagen and hyaluronic acid have been developed and are regularly taken by many people [8][9][10]. Cosmetics are expected to be absorbed from the skin and foods are expected to be absorbed from the gastrointestinal tract.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Absorbability of Macromolecular Substances in the Oral Mucosa and Skin using a Three-Dimensional Tissue Culture Model

Takenokuchi¹,

Kadoyama²,

Yoshida³

et al. 2018

Biol Med

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Introduction:Collagen exists in various connective tissues and helps to provide them mechanical strength and elasticity. The main component of the tendon is properly arranged collagen fibers withstanding very strong forces. The compactly packed collagen fine fibers inside the bone and cartilage increase their elasticity. Collagen also helps skin elasticity and strength. Hyaluronic acid widely exists in extracellular matrix, such as joints and skin. It plays an important role in maintaining cartilage function by making ultra-macromolecular complexes with aggrecan or protein.These collagen and hyaluronic acid decrease with age. Therefore oral supplementation or cosmetics containing them are developed day by day and catch interests of people trackleing anti-aging. The objective of this study was to evaluate and compare the absorbability of macromolecular substances in the oral mucosa and in the skin. Methods:As animal experiments cannot be performed for the evaluation of cosmetics, we used a threedimensional oral mucosa culture model and a three-dimensional epidermis culture model. The absorbability of macromolecular substances with molecular weights from 4,000 to 2,000,000 Da was compared between the oral mucosa model and the skin model. Results:In the skin model, the amount permeated were quite low on all molecular weight. In the oral mucosa model, it absorbed much more compared with that of skin model, though the amount decreased according to the molecular weight. Conclusion:This result was considered due to the absence of the stratum corneum in the oral mucosa. High absorbability through oral mucosa shows the possibility of a new absorption pathway of macromolecular substances.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Absorbability of Macromolecular Substances in the Oral Mucosa and Skin using a Three-Dimensional Tissue Culture Model

Takenokuchi¹,

Kadoyama²,

Yoshida³

et al. 2018

Biol Med

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“…However, even with this increase in patient interest and market share, the use of collagen supplementation in dermatology remains controversial due to the lack of regulation on quality and quantity of ingredients in OTC collagen supplements [164], [171]. Maria et.al, 2019 reported improvement of general skin conditions, acting in different mechanisms by oral supplementation and topical application of hydrolyzed proteins [165].…”

Section: Anti-pollution Preparationsmentioning

confidence: 99%

Skin Aging & Modern Age Anti-aging Strategies

Mohiuddin¹

2019

GJMR

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As the most voluminous organ of the body that is exposed to the outer environment, the skin suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features such as wrinkling, loss of elasticity, laxity, and rough-textured appearance. This aging process is accompanied with phenotypic changes in cutaneous cells as well as structural and functional changes in extracellular matrix components such as collagens and elastin. With intrinsic aging, structural changes occur in the skin as a natural consequence of the biological changes over time and produce a certain number of histological, physiological, and biochemical modifications. Intrinsic aging is determined genetically (influence of gender and ethnic group), variable in function of skin site, and also influenced by hormonal changes. Visually it is characterized by fine wrinkles. By comparison, “photoaging” is the term used to describe the changes occurring in the skin, resulting from repetitive exposure to sunlight. The histological, physiological, and biochemical changes in the different layers of the skin are much more drastic. From a mechanical point of view, human skin appears as a layered composite containing the stiff thin cover layer presented by the stratum corneum, below which are the more compliant layers of viable epidermis and dermis and further below the much more compliant adjacent layer of subcutaneous white adipose tissue.

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“…Aging of the skin is a degenerative process driven by a decline in physiological function. While it is partially intrinsic, extrinsic factors, such as pollution, sun exposure, and lifestyle can increase oxidation levels and contribute to chronic inflammation, which can accelerate aging processes . Lifestyle factors can include nutritional and smoking statuses.…”

Section: Introductionmentioning

confidence: 99%

“…While it is partially intrinsic, extrinsic factors, such as pollution, sun exposure, and lifestyle can increase oxidation levels and contribute to chronic inflammation, which can accelerate aging processes. 1 Lifestyle factors can include nutritional and smoking statuses. The progression of skin aging is associated with decreased collagen density and dermal thickness in addition to a reduction in the synthesis and replacement of vital structural proteins.…”

Section: Introductionmentioning

confidence: 99%

Oral collagen supplementation for skin aging: A fad or the future?

Jhawar

Wang

Saedi

2019

J of Cosmetic Dermatology

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In recent years, oral collagen supplements have become a popular and trendy treatment in the world of skin health. It has been widely marketed to consumers for purported benefits in wrinkle reduction, skin‐rejuvenation, skin‐aging reversal, and skin plumping. However, there are currently limited data available in the literature and much regarding its possible effects on the skin has yet to be fully elucidated and understood. Here, we summarize some of the prominent studies in the literature and offer an evaluation of oral collagen supplementation for skin health.

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Improvement of dermal parameters in aged skin after oral use of a nutrient supplement

Cited by 26 publications

References 22 publications

Evaluation of Absorbability of Macromolecular Substances in the Oral Mucosa and Skin using a Three-Dimensional Tissue Culture Model

Evaluation of Absorbability of Macromolecular Substances in the Oral Mucosa and Skin using a Three-Dimensional Tissue Culture Model

Skin Aging & Modern Age Anti-aging Strategies

Oral collagen supplementation for skin aging: A fad or the future?

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