Improvement of activity-related knee joint discomfort following supplementation of specific collagen peptides

Abstract

this article has been changed to the CC BY 4.0 license. The PDF and HTML versions of the article have been modified accordingly. Abstract:The aim of the study was to evaluate the use of specific collagen peptides in reducing pain in athletes with functional knee problems during sport. Athletic subjects (n = 139) with functional knee pain ingested 5 g of bioactive collagen peptides (BCP) or a placebo per day for 12 weeks. The primary outcome of the study was a change in pain intensity during activity, which was evaluated by the participants and the attending physicians using a visual analogue scale (VAS). As secondary endpoints, pain intensity under resting conditions, the range of motion of the knee joint, and the use of additional therapeutic options were assessed. The results revealed a statistically significant improvement in activity-related pain intensity in the verum group compared with placebo. (⌬VAS BCP = 19.5 ± 2.4; ⌬VAS Placebo = 13.9 ± 2.1; p = 0.046). The results were confirmed by the physician's assessment. (⌬VAS BCP = 16.7 ± 1.8; ⌬VAS Placebo = 12.2 ± 1.8; p = 0.021). Pain under resting conditions was also improved, but no significance compared with placebo was detected (⌬VAS BCP = 10.2 ± 18.4; ⌬VAS Placebo = 7.4 ± 15.2; p = 0.209). Due to the high joint mobility at baseline, no significant changes of this parameter could be detected. The use of additional treatment options was significantly reduced after BCP intake. The study demonstrated that the supplementation of specific collagen peptides in young adults with functional knee problems led to a statistically significant improvement of activity-related joint pain.

Enzymatic Hydrolysis of a Collagen Hydrolysate Enhances Postprandial Absorption Rate—A Randomized Controlled Trial

“…In addition, ingestion of EHC led to significantly higher plasma concentrations of glycine, proline and hydroxyproline compared to non-hydrolyzed collagen. Notably, these AAs have been connected with the potential beneficial effects of collagen supplementation on tendinopathy and articular joint pain experienced in both OA patients and athletes [7,8,9,10,11,12,13,14,21,22]. As net collagen synthesis is negative in OA patients, enhancing collagen synthesis has been proposed to help regeneration of cartilage [11,22].…”

“…Collagen is an abundant structural protein present in connective tissue. Besides its nutritional value as a protein source, dietary supplementation with collagen-derived peptide sources has been suggested to provide beneficial effects in patients with tendinopathy [5,6,7], chronic joint instability [8], osteoarthritis (OA) [3,9,10,11,12], and activity-related joint pain [13,14]. Thus, nutritional interventions focusing on increasing the amino acid (AA) components of collagen have been suggested to improve collagen synthesis of collagen-rich tissues such as ligaments and bones [5] and potentially slow the degenerative process in OA affected joints [11].…”

Identification of food-derived peptides in human blood after ingestion of corn and wheat gluten hydrolysates

“…In most cases, Pro-Hyp accounts for more than 50% of total collagen peptides in human plasma. Pro-Hyp enhances fibroblast growth on a collagen gel (Shigemura et al, 2009;2011) and production of glycosaminoglycans by fibroblasts and chondrocytes (Nakatani et al, 2009;Ohara et al, 2010), which partly explain the beneficial effects of collagen hydrolysates; improvement of wound healing (Sugihara et al, 2015) and skin (Proksch et al, 2014a,b) and joint conditions (Zdzieblik et al, 2017). However, collagen hydrolysates ingested comprised collagen peptides with an average molecular weight of 5000 Da and did not contain Pro-Hyp (Iwai et al, 2005).…”

Changes in composition and content of food‐derived peptide in human blood after daily ingestion of collagen hydrolysate for 4 weeks

“…In addition, human trials have demonstrated that the daily ingestion of collagen hydrolysate improves osteoarthritis‐related symptoms and skin conditions after several weeks . Moreover, a combination of daily ingestion of collagen hydrolysate and resistance training for 12 weeks increases muscle strength in sarcopenic patients …”