Improvement of acid resistance of Zn-doped dentin by newly generated chemical bonds

Naito, Katsuaki; KUWAHARA, Yasutaka; Yamamoto, Hiroko; Matsuda, Yasuhiro; Okuyama, Katsushi; Ishimoto, Takuya; Nakano, Takayoshi; Yamashita, Hiromi; Hayashi, Mikako

doi:10.1016/j.matdes.2022.110412

Cited by 7 publications

(8 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Since the quantitative analysis of fluorine in hard tissue is complicated using specific X-ray analyses, we developed and employed an analytical method based on the use of specific gamma rays [16,[27][28][29][30] to analyze the fluorine contents of the samples. It should be noted that the differences in fluorine values obtained for the EDS and the in-air micro-PIXE/PIGE techniques can be attributed to the different sensitivities and specificities of the analytical methods.…”

Section: Discussionmentioning

confidence: 99%

Potential of Fluoride-Containing Zinc Oxide and Copper Oxide Nanocomposites on Dentin Bonding Ability

et al. 2022

Self Cite

View full text Add to dashboard Cite

Despite recent advances in bonding restorations, which are the basis of restorative dentistry, secondary caries are still able to form. Previously, a novel fluoride-containing zinc and copper (ZCF) nanocomposite was introduced to prevent the formation of caries due to its antibacterial activity. In this study, we studied the impact of ZCF nanoparticles on the adhesive strength of bonding restorations through micro-tensile bond strength (µTBS) testing. The impact of antibacterial and matrix metalloproteinase (MMP) inhibitors on the nanoparticles was also examined. The nanocomposites were prepared using a simple one-step homogeneous co-precipitation method at a low temperature. A self-etch adhesive was applied to 10 extracted caries-free human molars with (test group) and without (control group) the ZCF nanoparticles. This was followed by composite resin build-up and µTBS testing, MMP activity assays, and evaluation of the antibacterial effects. The results showed no significant differences in the µTBS between the ZCF and the control groups. However, the ZCF exhibited a significant inhibitory effect against MMP-2, MMP-8, and MMP-9, in addition to an antibacterial effect on Streptococcus mutans. Therefore, the present study demonstrated that the addition of ZCF nanoparticles to adhesive systems can result in MMP inhibition and antibacterial action while maintaining the mechanical properties of the bonding restorations.

show abstract

Section: Discussionmentioning

confidence: 99%

Potential of Fluoride-Containing Zinc Oxide and Copper Oxide Nanocomposites on Dentin Bonding Ability

et al. 2022

Self Cite

View full text Add to dashboard Cite

show abstract

“…In the pulp, odontoblasts are the cells responsible for the formation and maintenance of the dentine [ 28 ]. The root anchors the tooth [ 29 ] to the jaw bones and is covered by another mineralised tissue (cementum) [ 30 ] that plays a crucial role in mechanical tooth retention and support [ 31 ]. Cementum is composed of two layers of cellular and acellular cementum [ 32 ].…”

Section: Demineralisation and Remineralisation Of Teethmentioning

confidence: 99%

“…Dentine replacement materials have been studied using the two techniques and the Ca K-edge [ 680 ]. Other elements were also analysed and Zn-doped dentine was investigated with K-edge, to study Zn effect on the acid resistance [ 31 ]. In studies on the treatment of caries, XAS Ca K-edge and Zn K-edge were also used to analyse glass ionomer cement synthesis for restoration purposes [ 681 ], as well as XAFS of Sr K-edge on enamel and dentine powder exposed to surface pre-reacted glass-ionomer [ 383 ].…”

Section: Synchrotron (Circular Particle Accelerator)mentioning

confidence: 99%

“…The data were extracted from Endnote software in ‘.txt’ format and manually edited to arrange the studies by techniques. In total, 31 terms were considered based on these studies [ 11 , 31 , 39 , 56 , 57 , 77 , 78 , 89 , 90 , 121 , 169 , 170 , 171 , 172 , 173 , 175 , 193 , 195 , 247 , 266 , 286 , 294 , 299 , 303 , 304 , 305 , 306 , 307 , 308 , 309 , 310 , 311 , 312 , 313 , 314 , 315 , 316 , 317 , 318 , 319 , 320 , 321 , 322 , 323 , 324 , 325 , 326 , 327 , 328 , 329 , 330 , ...…”

Section: Figurementioning

confidence: 99%

See 1 more Smart Citation

Synchrotron X-ray Studies of the Structural and Functional Hierarchies in Mineralised Human Dental Enamel: A State-of-the-Art Review

et al. 2023

View full text Add to dashboard Cite

Hard dental tissues possess a complex hierarchical structure that is particularly evident in enamel, the most mineralised substance in the human body. Its complex and interlinked organisation at the Ångstrom (crystal lattice), nano-, micro-, and macro-scales is the result of evolutionary optimisation for mechanical and functional performance: hardness and stiffness, fracture toughness, thermal, and chemical resistance. Understanding the physical–chemical–structural relationships at each scale requires the application of appropriately sensitive and resolving probes. Synchrotron X-ray techniques offer the possibility to progress significantly beyond the capabilities of conventional laboratory instruments, i.e., X-ray diffractometers, and electron and atomic force microscopes. The last few decades have witnessed the accumulation of results obtained from X-ray scattering (diffraction), spectroscopy (including polarisation analysis), and imaging (including ptychography and tomography). The current article presents a multi-disciplinary review of nearly 40 years of discoveries and advancements, primarily pertaining to the study of enamel and its demineralisation (caries), but also linked to the investigations of other mineralised tissues such as dentine, bone, etc. The modelling approaches informed by these observations are also overviewed. The strategic aim of the present review was to identify and evaluate prospective avenues for analysing dental tissues and developing treatments and prophylaxis for improved dental health.

show abstract

“…To compare the demineralization and remineralization of dentin, we developed an automatic pH cycle device [ 12 ] and examined the demineralization and remineralization of dentin [ 13 , 14 ]. In addition, as reported previously, we mapped the distribution of F in dentin by in-air micro-particle-induced X-ray/gamma-ray emission (PIXE/PIGE) analysis and quantitatively analyzed the amount of fluoride uptake in dentin [ 6 , 7 , 15 , 16 ].…”

Section: Introductionmentioning

confidence: 99%

Inhibition of Demineralization of Dentin by Fluoride-Containing Hydrogel Desensitizers: An In Vitro Study

Matsuda

Altankhishig

Okuyama

et al. 2022

JFB

Self Cite

View full text Add to dashboard Cite

Several desensitizers routinely used clinically for dentin hypersensitivity are expected to inhibit demineralization. This study aimed to evaluate the effectiveness of sealing materials in inhibiting demineralization and increasing fluorine (F) uptake by acid-treated root surfaces. Five noncarious extracted human teeth were used to produce specimens. Three different fluoride-containing materials, namely “MS Coat F” (MS), “MS Coat Hys Block Gel” (HS), and CTX2 Varnish (FV), were used herein. Each material was applied to the demineralized root surface. Single sections were obtained from each specimen. All surfaces of each specimen, except the polished surface, were covered with wax and immersed in an automatic pH cycling system for 2 weeks. Fluorine and calcium distributions in the carious lesions of each specimen were evaluated using proton-induced gamma emission (PIGE) and X-ray (PIXE) techniques, respectively. Dentin demineralization was analyzed using transverse microradiography (TMR) before and after pH cycling. µPIXE/PIGE analysis demonstrated that all sample groups showed increased fluoride uptake on the root surface. TMR analysis revealed that both HS and FV showed significantly lower integrated mineral loss values than the control group. All three samples demonstrated a tendency towards increased fluoride uptake from fluoride-containing hypersensitivity desensitizers and a demineralization inhibition effect on root dentin.

show abstract

Improvement of acid resistance of Zn-doped dentin by newly generated chemical bonds

Cited by 7 publications

References 49 publications

Potential of Fluoride-Containing Zinc Oxide and Copper Oxide Nanocomposites on Dentin Bonding Ability

Potential of Fluoride-Containing Zinc Oxide and Copper Oxide Nanocomposites on Dentin Bonding Ability

Synchrotron X-ray Studies of the Structural and Functional Hierarchies in Mineralised Human Dental Enamel: A State-of-the-Art Review

Inhibition of Demineralization of Dentin by Fluoride-Containing Hydrogel Desensitizers: An In Vitro Study

Contact Info

Product

Resources

About