Potential of Fluoride-Containing Zinc Oxide and Copper Oxide Nanocomposites on Dentin Bonding Ability

Altankhishig, Bayarchimeg; Matsuda, Yasuhiro; Nagano-Takebe, Futami; Okuyama, Katsushi; Yamamoto, Hiroko; Sakurai, Masaki; Naito, Katsuaki; Hayashi, Mikako; Sano, Hidehiko; Sidhu, Sharanbir K.; Saito, Takashi

doi:10.3390/nano12081291

Cited by 8 publications

(10 citation statements)

References 41 publications

(49 reference statements)

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“…The activity of these MMPs is concentration-dependent, is reversibly inhibited by fluoride at 200 ppm or higher, and irreversibly inhibited at 5000 ppm or higher [ 29 ]. Zinc and copper also inhibit MMPs [ 30 ]. Therefore, the application of fluoride can be expected not only to inhibit demineralization but also to inhibit the degradation of collagen fibers in dentin.…”

Section: Discussionmentioning

confidence: 99%

Inhibition of Demineralization of Dentin by Fluoride-Containing Hydrogel Desensitizers: An In Vitro Study

Matsuda

Altankhishig

Okuyama

et al. 2022

JFB

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Several desensitizers routinely used clinically for dentin hypersensitivity are expected to inhibit demineralization. This study aimed to evaluate the effectiveness of sealing materials in inhibiting demineralization and increasing fluorine (F) uptake by acid-treated root surfaces. Five noncarious extracted human teeth were used to produce specimens. Three different fluoride-containing materials, namely “MS Coat F” (MS), “MS Coat Hys Block Gel” (HS), and CTX2 Varnish (FV), were used herein. Each material was applied to the demineralized root surface. Single sections were obtained from each specimen. All surfaces of each specimen, except the polished surface, were covered with wax and immersed in an automatic pH cycling system for 2 weeks. Fluorine and calcium distributions in the carious lesions of each specimen were evaluated using proton-induced gamma emission (PIGE) and X-ray (PIXE) techniques, respectively. Dentin demineralization was analyzed using transverse microradiography (TMR) before and after pH cycling. µPIXE/PIGE analysis demonstrated that all sample groups showed increased fluoride uptake on the root surface. TMR analysis revealed that both HS and FV showed significantly lower integrated mineral loss values than the control group. All three samples demonstrated a tendency towards increased fluoride uptake from fluoride-containing hypersensitivity desensitizers and a demineralization inhibition effect on root dentin.

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Section: Discussionmentioning

confidence: 99%

Inhibition of Demineralization of Dentin by Fluoride-Containing Hydrogel Desensitizers: An In Vitro Study

Matsuda

Altankhishig

Okuyama

et al. 2022

JFB

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“…Covarrubias et al synthesised copper chitosan hybrid nanoparticles with antimicrobial activities against Streptococcus mutans [ 133 ]. Altankhishig et al demonstrated that incorporating zinc and copper nanocomposite gave the adhesive system antibacterial properties [ 134 ].…”

Section: Metal and Metal-oxide Nanomaterialsmentioning

confidence: 99%

Bioactive Materials for Caries Management: A Literature Review

et al. 2023

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Researchers have developed novel bioactive materials for caries management. Many clinicians also favour these materials, which fit their contemporary practice philosophy of using the medical model of caries management and minimally invasive dentistry. Although there is no consensus on the definition of bioactive materials, bioactive materials in cariology are generally considered to be those that can form hydroxyapatite crystals on the tooth surface. Common bioactive materials include fluoride-based materials, calcium- and phosphate-based materials, graphene-based materials, metal and metal-oxide nanomaterials and peptide-based materials. Silver diamine fluoride (SDF) is a fluoride-based material containing silver; silver is antibacterial and fluoride promotes remineralisation. Casein phosphopeptide-amorphous calcium phosphate is a calcium- and phosphate-based material that can be added to toothpaste and chewing gum for caries prevention. Researchers use graphene-based materials and metal or metal-oxide nanomaterials as anticaries agents. Graphene-based materials, such as graphene oxide-silver, have antibacterial and mineralising properties. Metal and metal-oxide nanomaterials, such as silver and copper oxide, are antimicrobial. Incorporating mineralising materials could introduce remineralising properties to metallic nanoparticles. Researchers have also developed antimicrobial peptides with mineralising properties for caries prevention. The purpose of this literature review is to provide an overview of current bioactive materials for caries management.

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“…Zn which is commonly used in dental materials and in mouth rinses at high concentrations acts as an inhibitor of MMPs [ 90 , 91 ]. Collagen is important for biomineralization, zinc improves hard-tissue mineralization by protecting collagen against MMPs [ 92 , 93 ]. Zn–CuO nanocomposites show lower embryotoxic than both ZnO and CuO, as a result, they may be considered safe antibacterial metal nanocomposites [ 94 ].…”

Section: Inorganic Nanomaterials As Anti Caries Agentmentioning

confidence: 99%

“…In this line, Matsuda et al introduced fluoride-containing ZnO and CuO nanocomposites as a strong antimicrobial agent [ 96 ]. More recently, Altankhishig et al investigated the impact of fluoride-containing ZnO and CuO nanocomposites on the adhesive strength of bonding restorations [ 92 ]. In addition, antibacterial and MMP inhibitors of them were assessed.…”

Section: Inorganic Nanomaterials As Anti Caries Agentmentioning

confidence: 99%