Improvement in symptoms of the syndrome of mitochondrial encephalopathy, lactic acidosis, and stroke-like symptoms (MELAS) following treatment with sympathomimetic amines – possible implications for improving fecundity in women of advanced reproductive age

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To describe a cause and treatment for chronic unremitting lower abdominal pain of long duration with unknown origin. Materials and Methods: A 50-year-old woman with 30 years of unexplained right lower quadrant pain was treated with dextroamphetamine sulfate. Results: Dramatic complete abrogation of the pain occurred within two weeks. The complete relief persisted for two years while she remains on therapy. Conclusions: Symphathetic neural hyperalgesia edema syndrome should be considered whenever there is refractory pelvic or abdominal pain.

Section: Discussionmentioning

confidence: 99%

Chronic unremitting lower abdominal pain quickly abrogated following treatment with amphetamine

Jh¹

2016

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“…Other clinical manifestations may involve unwanted chemicals infusing into mitochondria causing muscle dysfunction. When skeletal muscles are involved, the clinical manifestation may be marked fatigue [4][5][6]. When it involves smooth muscle, various gastrointestinal motility disorders ensue, e.g., achalasia, gastroparesis, and pseudointestinal obstruction [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Marked improvement of severe gastroparesis following high dosage, but very well tolerated, dextroamphetamine sulfate

Check¹,

Cohen²

2017

Purpose: To determine if treatment with dextroamphetamine sulfate could provide palliation for severe treatment refractory gastroparesis. Materials and Methods: Dextroamphetamine sulfate 15 immediate release tablets were initiated and the dose titrated upwards according to the degree of improvement vs. side effects. Results: The large majority of the symptoms of abdominal pain, very severe vomiting, and diarrhea was markedly improved but it took a very high dosage of amphetamine salts (150 mg). This dosage, however, did not cause any side effects. Conclusions: The gynecologist, who also is frequently asked to evaluate gastrointestinal (GI) symptomatology, is more cognizant of the increased cellular permeability syndrome, and thus may be called upon to treat certain GI conditions that should be more appropriate for the GI specialist to treat. The more articles that appear in the literature, the better the chance to promulgate the knowledge of these conditions, e.g., gastroparesis, to other specialties.

“…Other conditions improved by dextroamphetamine sulfate did not involve pain either [16][17][18][19][20][21][22]. Thus we considered other names.…”

mentioning

confidence: 99%

Changing the name of a syndrome: sympathetic neural hyperalgesia edema syndrome becomes – the increased cellular permeability syndrome

Check¹

2017

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I wrote an editorial entitled "Sympathomimetic amines are a safe, highly effective therapy for several female chronic disorders that do not respond well to conventional therapy" [1]. Since we have written a large number of case reports and a previous editorial on treating pelvic pain, hopefully some of our readers have tried this therapy even before the last editorial. If not, from these past case report studies, hopefully the last editorial has convinced you to try this therapy for a variety of female disorders [1]. If you have tried it, I know you and your patients are very satisfied.This condition is not limited to women but seems to be more common (similar to autoimmune disorders). In fact, I think this condition, that we have referred to as the sympathetic neural hyperalgesia edema syndrome, plays a critical role in most autoimmune disorders. A large majority of so-called autoimmune diseases are much more effectively treated by dextroamphetamine sulfate rather than glucocorticoids and/or biological immunosuppressives with far less risk and much less expense when compared to the biologicals.This condition is extremely common, yet it is unknown to most clinicians with the exception of the readership for Clinical and Experimental Obstetrics & Gynecology. The reason for this is that it is not being promulgated by large pharmaceutical companies because dextroamphetamine sulfate is available as a generic drug. Furthermore, the plethora of published articles would prevent a large pharmaceutical company from obtaining a patent even if they made some slight modifications to the formulation.Probably the first name given to a form of this condition was provided by George Thorn (who was the head of endocrinology at Harvard Medical School) over 45 years ago and he used the name "idiopathic edema" [2]. He also called it "periodic swelling" [2]. Since the condition became worse from morning until evening, and it was clear that standing erect made the condition worse, I sometimes referred to the condition as idiopathic orthostatic edema [3].