Improved, Rapid Spectrophotofluorometric Method for Assay of Isoproterenol Hydrochloride Injections: A Comparative Study

Prasad, Vadlamani K.; Ricci, Rebecca; Nunning, B C; Granatek, A.P.

doi:10.1002/jps.2600620716

Cited by 11 publications

(2 citation statements)

References 7 publications

(6 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Stabilizers used in isoprenaline injection include sodium metabisulphite (0.1%) which has been shown by biological assay to be effective in retarding the oxidation of heatsterilized isoprenaline solutions (0.01%) in ampoules (3). However, isoprenaline interacts with bisulphite ions to form isoprenalinesulphonic acid, which is pharmacologically inactive (4)(5)(6). The antioxidant synergist disodium edetate (0.01%) was not effective as a stabilizer for isoprenaline spray although it did protect phenylephrine eye-drops from oxidation (7).…”

Section: Introductionmentioning

confidence: 99%

Effects of Ascorbic Acid and Disodium Edetate on the Stability of Isoprenaline Hydrochloride Injection

1984

View full text Add to dashboard Cite

SUMMARY Disodium edetate (0.01%), either alone or in combination with ascorbic acid (0.1%) was an effective stabilizer for isoprenaline injection B.P. but adjustment to pH 2.8 was necessary. The bubbling of nitrogen through the solution in the ampoule before sealing did not prevent degradation in unprotected solutions. Solutions sterilized by filtration or by autoclaving for 30 min at 116° were stable for at least 1 year at 5° or 25°.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of Ascorbic Acid and Disodium Edetate on the Stability of Isoprenaline Hydrochloride Injection

1984

View full text Add to dashboard Cite

show abstract

“…As a consequence of the limitations, most notably in specificity, of the compendia1 assay procedures for epinephrine, isoproterenol, and phen, ylephrine in dosage forms, alternative methods that encompass various analytical techniques have appeared (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30).…”

mentioning

confidence: 99%