Improved outcomes after low‐concentration hypochlorous acid nasal irrigation in pediatric chronic sinusitis

Cho, Hyung‐Ju; Min, Hyun Jin; Chung, Hyo Jin; Park, Do Yang; Seong, Sang Yeob; Yoon, Joo Heon; Lee, Jeung Gweon; Kim, Chang Hoon

doi:10.1002/lary.25605

Cited by 24 publications

(17 citation statements)

References 24 publications

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“…In addition to the mentioned indications for HOCl as a gargling and wound cleansing solution, it is widely used for water treatment, food sanitization, hard surface disinfection, and in cosmetics [10]. The antibacterial effect of HOCl has been shown in children suffering from atopic dermatitis with secondary bacterial infections [11] and in pediatric chronic sinusitis using 3.5 ppm nasal irrigation [12]. Moreover, it is an effective part of the innate immune system [13].…”

Section: Discussionmentioning

confidence: 99%

A Concept for the Reduction of Mucosal SARS-CoV-2 Load using Hypochloric Acid Solutions

Mueller

Winter²,

Renner

2021

Drug Res (Stuttg)

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During the next few months or years, vaccination against SARS-CoV-2 infection will significantly reduce the morbidity and mortality of COVID-19. However, additional measures are needed to protect those who are still not immunized. This is even more important in view of new viral mutations that result in increased transmission rates. We propose that the use of long-standing medicinal solutions based on hypochloric acid (HOCl) and intended for application on wounds may be effective as a gargling solution or nasal irrigation in blocking transmission of the virus. Here, we propose the use of HOCl-containing solutions for blocking the transmission of SARS-CoV-2 in combination with other prevention measures. This may constitute another important cornerstone in the fight against the COVID-19 pandemic.

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Section: Discussionmentioning

confidence: 99%

A Concept for the Reduction of Mucosal SARS-CoV-2 Load using Hypochloric Acid Solutions

Mueller

Winter²,

Renner

2021

Drug Res (Stuttg)

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show abstract

“…It has been reported that a low concentration of HOCL solution demonstrated strong antibacterial and antifungal effects [ 1 ]. Cho et al further found that nasal irrigation with a low concentration of HOCL solution improved outcomes of pediatric CRS patients [ 3 ]. Patients received nasal irrigation with 30 ml of HOCL for 10 seconds twice a day while sitting or standing.…”

Section: Discussionmentioning

confidence: 99%

“…NeutroPhase contains pure HOCl (0.01% concentration in a 0.9% saline solution at pH 3.5–6.5). It is commercially available and easy to use as compared with the production of HOCl by electrolysis of isotonic NS using a device, as performed in other studies [ 3 ]. It has been shown that NeutroPhase has rapid bactericidal activity [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

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Antibacterial Effect of Hypochlorous Acid Solution on Nasal Discharge from Patients with Chronic Rhinosinusitis

Lin

Jiang

2018

International Journal of Otolaryngology

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Purpose The antibacterial effect of hypochlorous acid (HOCl) solution on nasal secretion of patients with chronic rhinosinusitis (CRS) was investigated. Materials and Methods Five swab specimens were collected from the middle meatus of CRS patients. The first one was placed directly in a Thanswab tube while all of the others were placed randomly into 4 glass tubes containing either HOCl solution, normal saline (NS), 75% alcohol, or povidone-iodine (PVPI) solution for one minute in the first part and for 5 minutes in the second part of the study before transfer to a Thanswab tube. Results Bacteria were cultured from 27 of 50 specimens when they were put directly in a Thanswab tube and from 26 after soaking in HOCl solution, 27 in NS, 13 in 75% alcohol, and 25 in PVPI solution for one minute. In the second part of the study, bacteria were cultured from 14 of 32 specimens when they were put directly in a Thanswab tube and from 14 after soaking in HOCl solution, 13 in NS, 3 in 75% alcohol, and 11 in PVPI solution for 5 minutes. Conclusions This study showed that HOCL solution did not exert an antibacterial effect on nasal secretion from CRS patients within 5 minutes.

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“…The novel findings from this pilot study should be investigated further with a larger cohort. Only a few studies have analyzed the effectiveness of nasal irrigation with low‐concentration hypochlorous acid (HOCL), 5‐7 but none have determined its effect on the sinus microbiota using molecular techniques.…”

Section: Figurementioning

confidence: 99%

Efficacy of neutral electrolyzed water in postoperative chronic rhinosinusitis patients—a pilot study

Lux

Johnston

Biswas

et al. 2020

Int Forum Allergy Rhinol

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Improved outcomes after low‐concentration hypochlorous acid nasal irrigation in pediatric chronic sinusitis

Abstract: 1b.

Cited by 24 publications

References 24 publications

A Concept for the Reduction of Mucosal SARS-CoV-2 Load using Hypochloric Acid Solutions

A Concept for the Reduction of Mucosal SARS-CoV-2 Load using Hypochloric Acid Solutions

Antibacterial Effect of Hypochlorous Acid Solution on Nasal Discharge from Patients with Chronic Rhinosinusitis

Efficacy of neutral electrolyzed water in postoperative chronic rhinosinusitis patients—a pilot study

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